Expression of angiogenic factors in patients with sporadic small bowel angiodysplasia

Journal of Clinical Gastroenterology

Volumn 49, Issue 10, 2015, Pages 831-836

  Holleran, Grainne ^a   Hall, Barry ^a   O'Regan, Myra ^b   Smith, Sinead ^a   McNamara, Deirdre ^a  

^a ADELAIDE AND MEATH HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Angiogenic factors; Angiopoietin; Capsule endoscopy; Small bowel angiodysplasia

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; ENDOGLIN; PLATELET DERIVED GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANGIOGENIN; C11ORF2 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PANCREATIC RIBONUCLEASE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ADULT; AGED; ANGIODYSPLASIA; ARTICLE; CAPSULE ENDOSCOPY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ELISA KIT; FEMALE; GASTROINTESTINAL DYSPLASIA; GASTROINTESTINAL MALFORMATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTESTINE BIOPSY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SMALL INTESTINE DISEASE; SPORADIC SMALL BOWEL ANGIODYSPLASIA; BIOPSY; BLOOD; CASE CONTROL STUDY; COMPLICATION; ENTEROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL HEMORRHAGE; GENETICS; METABOLISM; MIDDLE AGED; SMALL INTESTINE; VASCULARIZATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANGIODYSPLASIA; ANGIOGENESIS INDUCING AGENTS; ANTIGENS, CD; BIOPSY; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; INTESTINAL DISEASES; INTESTINE, SMALL; MALE; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR, TIE-2; RECEPTORS, CELL SURFACE; RIBONUCLEASE, PANCREATIC; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VESICULAR TRANSPORT PROTEINS;

EID: 84944045821     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0000000000000260     Document Type: Article

References (25)

1. Peter S. Unfolding the plot of obscure gastrointestinal bleeding: excellent or elemental. Clin Gastroenterol Hepatol. 2012;10:1386-1388.
2. Foutch PG. Angiodysplasia of the gastrointestinal tract. Am J Gastroenterol. 1993;88:807-818.
3. Junquera F, Feu F, Papo M, et al. A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. Gastroenterology. 2001;121:1073-1079.
4. Saperas E, Dot J, Videla S, et al. Capsule endoscopy versus computed tomographic or standard angiography for the diagnosis of obscure gastrointestinal bleeding. Am J Gastroenterol. 2007;102:731-737.
5. Lee SS, Oh TS, Kim HJ, et al. Obscure gastrointestinal bleeding: diagnostic performance of multidetector CT enterography. Radiology. 2011;259:739-748.
6. Milano A, Balatsinou C, Fillipone A, et al. A prospective evaluation of iron deficiency anaemia in the GI endoscopy setting: role of standard endoscopy, video-capsule endoscopy, and CT-enterocolysis. Gastrointest Endosc. 2011;73:1002-1008.
7. Triester SL, Leighton JA, Leontiadis JL, et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding. Am J Gastroenterol. 2005;100:2407-2418.
8. Holleran G, Hall B, Hussey M, et al. Small bowel angiodysplasia and novel disease associations: a cohort study. Scand J Gastroenterol. 2013;48:433-438.
9. Nissenson AR, Goodnough LT, Dubois LW. Anaemia: not just an innocent bystander? Arch Intern Med. 2003;163: 1400-1404.
10. Szilagyi A, Ghali MP. Pharmacological therapy of vascular malformations of the gastrointestinal tract. Review. Can J Gastroenterol. 2006;20:171-178.
11. Cappell MS, Gupta A. A changing epidemiology of gastrointestinal angiodysplasia with increasing recognition of clinically milder cases: angiodysplasia tend to produce mild chronic gastrointestinal bleeding in a study of 47 consecutive patients admitted from 1980-1989. Am J Gastroenterology. 1992;87:201-206.
12. Gerson LB, Batenic MA, Newsom SL, et al. Long-term outcomes after double-balloon enteroscopy for obscure gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2009;7: 664-669.
13. Sami SS, Al-Araji SA, Ragunath K. Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management. Aliment Pharmacol Ther. 2014;39:15-34.
14. Junquera F, Saperas E, de Torres I, et al. Increased expression of angiogenic factors in human colonic angiodysplasia. Am J Gastroenterol. 1999;94:1070-1076.
15. Ojeda-Fernandez L, Barrios L, Rodriguez-Barbero A, et al. Reduced plasma levels of Ang-2 and sEng as novel biomarkers in hereditary hemorrhagic telangiectasia (HHT). Clin Chim Acta. 2010;411:494-499.
16. Kümpers P, Lukasz A, David S, et al. Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care. 2008;12:R147. DOI: 10.1186/cc7130.
17. Tran HT, Liu Y, Zurita AJ, et al. Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials. Lancet Oncol. 2012; 13:827-837.
18. Fagiani E, Christofori G. Angiopoietins in angiogenesis. Cancer Lett. 2013;328:18-26.
19. Fiedler U, Scharpfenecker M, Koidl S, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004;103:4150-4156.
20. Seegar TC, Eller B, Tzvetkova-Robev D, et al. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. Mol Cell. 2010;37:643-655.
21. Davis J, Yeo T, Piera K, et al. Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care. 2010;14:R89.
22. Wilson PM, LaBonte MJ, Lenz HJ. Assessing the in vivo efficacy of biologic antiangiogenic therapies. Cancer Chemother Pharmacol. 2013;71:1-12.
23. Duray PH, Marcal JM, LiVolsi VA, et al. Small intestinal angiodysplasia in the elderly. J Clin Gastroenterol. 1984;6: 311-319.
24. Hashizume H, Falcón BL, Kuroda T, et al. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 2010;70: 2213-2223.
25. Felcht M, Luck R, Schering A, et al. Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signalling. J Clin Invest. 2012;122:1991-2005.