Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC)

Cancer Biology and Therapy

Volumn 16, Issue 4, 2015, Pages 634-643

  Zhao, Qingnan ^a   Gu, Xiajing ^a   Zhang, Chun ^a   Lu, Qin ^a   Chen, Hongzhuan ^a   Xu, Lu ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

AKT; Autoparacrine; Epithelial mesenchymal transition; M2 muscarinic receptor; MAPK ERK; Non neuronal acetylcholine; Non small cell lung cancer

Indexed keywords

METHOCTRAMINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; PROTEIN KINASE B; SHORT HAIRPIN RNA; ACETYLCHOLINE; ANTINEOPLASTIC AGENT; DIAMINE; MITOGEN ACTIVATED PROTEIN KINASE;

A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPARACRINE SIGNALING; CANCER INHIBITION; CELL PROLIFERATION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PARACRINE SIGNALING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; TUMOR XENOGRAFT; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG EFFECTS; LUNG NEOPLASMS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ACETYLCHOLINE; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DIAMINES; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, MUSCARINIC M2; SIGNAL TRANSDUCTION;

EID: 84943760002     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.1080/15384047.2015.1029835     Document Type: Article

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