Cell models to study cell-to-cell transmission of α-synuclein

Methods in Molecular Biology

Volumn 1345, Issue , 2016, Pages 291-298

  Bae, Eun Jin ^a   Lee, He Jin ^a   Lee, Seung Jae ^a  

^a NONE

Author keywords

Neurodegenerative diseases; Parkinson s disease; Protein aggregation; Transcellular transmission; Synuclein

Indexed keywords

ALPHA SYNUCLEIN;

AUTOFLUORESCENCE; CELL CULTURE; CELL LABELING; CELL TO CELL TRANSMISSION; CELLS BY FUNCTION; COCULTURE; COMPLEMENT SYSTEM; GENETIC TRANSFECTION; HUMAN; HUMAN CLONING; PROTEIN AGGREGATION; SHUTTLE VECTOR; TISSUE CULTURE; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL CULTURE TECHNIQUE; CHEMISTRY; GENETICS; MOLECULAR BIOLOGY; PARKINSON DISEASE; PROCEDURES; PROTEINOSIS;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL CULTURE TECHNIQUES; HUMANS; MOLECULAR BIOLOGY; PARKINSON DISEASE; PROTEIN AGGREGATION, PATHOLOGICAL;

EID: 84943737877     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2978-8_19     Document Type: Chapter

References (13)

1. Ross CA, Poirier MA (2004) Protein aggregation and neurodegenerative disease. Nat Med 10(Suppl):S10-S17
2. Polymenidou M, Cleveland DW (2012) Prionlike spread of protein aggregates in neurodegeneration. J Exp Med 209:889-893
3. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E (2010) Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 6:702-706
4. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388:839-840
5. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 95:6469-6473
6. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res 318:121-134
7. Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 106:13010-13015
8. Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson’s disease. Nat Med 14:504-506
9. Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Bjorklund A, Widner H, Revesz T, Lindvall O, Brundin P (2008) Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nat Med 14:501-503
10. Mendez I, Vinuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski JQ, Isacson O (2008) Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years. Nat Med 14:507-509
11. Lee HJ, Suk JE, Bae EJ, Lee JH, Paik SR, Lee SJ (2008) Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol 40:1835-1849
12. Lee HJ, Patel S, Lee SJ (2005) Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 25:6016-6024
13. Lee HJ, Bae EJ, Jang A, Ho DH, Cho ED, Suk JE, Yun YM, Lee SJ (2011) Enzyme-linked immunosorbent assays for alpha-synuclein with species and multimeric state specificities. J Neurosci Methods 199:249-257