Monocytic MDSCs regulate macrophage-mediated xenogenic cytotoxicity

Transplant Immunology

Volumn 33, Issue 2, 2015, Pages 140-145

  Maeda, Akira ^a   Eguchi, Hiroshi ^a   Nakahata, Kengo ^a   Lo, Pei Chi ^a   Yamanaka, Kazuaki ^a   Kawamura, Takuji ^a   Matsuura, Rei ^a   Sakai, Rieko ^a   Asada, Mayumi ^a   Okuyama, Hiroomi ^a   Miyagawa, Shuji ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Indoleamine 2,3 dioxygenase (IDO); Macrophage mediated cytotoxicity; Myeloid derived suppressor cells (MDSCs); Xenotransplantation

Indexed keywords

ARGINASE 1; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 1; NITRIC OXIDE; UNCLASSIFIED DRUG; 1-METHYLTRYPTOPHAN; TRYPTOPHAN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL THERAPY; CONTROLLED STUDY; ENZYME MECHANISM; GRAFT REJECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; LYMPHOCYTE FUNCTION; MACROPHAGE; MACROPHAGE ACTIVATION; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PIG; PRIORITY JOURNAL; SUPPRESSOR CELL; XENOTRANSPLANTATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; CELL CULTURE; CYTOTOXICITY; DRUG EFFECTS; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; METABOLISM; XENOGRAFT;

CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MACROPHAGE ACTIVATION; MACROPHAGES; MYELOID CELLS; NITRIC OXIDE; TRANSPLANTATION, HETEROLOGOUS; TRYPTOPHAN;

EID: 84943664768     PISSN: 09663274     EISSN: 18785492     Source Type: Journal    
DOI: 10.1016/j.trim.2015.07.002     Document Type: Article

References (31)

1. Puga Yung G., Schneider M.K., Seebach J.D. Immune responses to alpha1,3-galactosyltransferase knockout pigs. Curr. Opin. Organ Transplant. 2009, 14:154-160.
2. Cadili A., Kneteman N. The role of macrophages in xenograft rejection. Transplant. Proc. 2008, 40:3289-3293.
3. Dorling A., Lombardi G., Binns R., Lechler R.I. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur. J. Immunol. 1996, 26:1378-1387.
4. Wennberg L., Rafael E., Liu J., Sundberg B., Wernersson A., et al. Allogeneic and xenogeneic islets are rejected by different and specific mechanisms: a study in rodents using a mixed allogeneic-xenogeneic islet transplantation model. Xenotransplantation 1997, 4:228-234.
5. Lin Y., Vandeputte M., Waer M. Natural killer cell- and macrophage-mediated rejection of concordant xenografts in the absence of T and B cell responses. J. Immunol. 1997, 158:5658-5667.
6. Schurman H.J., Cheng J., Lam T. Pathology of xenograft rejection: a commentary. Xenotransplantation 2003, 10:293-299.
7. Fox A., Mountford J., Braakhuis A., Harrison L.C. Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection. J. Immunol. 2001, 166:2133-2140.
8. Fox A., Koulmanda M., Mandel T.E., van Rooijen N., Harrison L.C. Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation 1998, 66:1407-1416.
9. Yi S., Hawthorne W.J., Lehnert A.M., Ha H., Wong J.K., et al. T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J. Immunol. 2003, 170:2750-2758.
10. Youn J.I., Nagaraj S., Collazo M., Gabrilovich D.I. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J. Immunol. 2009, 181:5791-5802.
11. Movahedi K., Guilliams M., Van den Bossche J., Van den Bergh R., Gysemans C., et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 2008, 111:4233-4244.
12. Dolcetti L., Peranzoni E., Ugel S., Marigo I., Fernandez Gomez A., et al. Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Eur. J. Immunol. 2010, 40:22-35.
13. Peranzoni E., Zilio S., Marigo I., Dolcetti L., Zanovello P., et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr. Opin. Immunol. 2010, 22:238-244.
14. Montero A.J., Diaz-Montero C.M., Kyriakopoulos C.E., Bronte V., Mandruzzato S. Myeloid-derived suppressor cells in cancer patients: a clinical perspective. J. Immunother. 2012, 35:107-115.
15. Vollbrecht T., Stirner R., Tufman A., Roider J., Huber R.M., et al. Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells. AIDS 2012, 26:F31-F37.
16. Fast D.J., Shannon B.J., Herriott M.J., Kennedy M.J., Rummage J.A., et al. Staphylococcal exotoxins stimulate nitric oxide dependent murine macrophage tumoricidal activity. Infect. Immun. 1991, 59:2987-2993.
17. Youn J.I., Kumar V., Collazo M., Nefedova Y., Condamine T., Cheng P., et al. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat. Immunol. 2013, 3:211-220.
18. Miki T., Sun H., Lee Y., Tandin A., Kovscek A.M., et al. Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant. Proc. 2001, 33:129-130.
19. Li J., Meinhardt A., Roehrich M.E., Golshayan D., Dudler J., et al. Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H3415-H3423.
20. Jalili R.B., Forouzandeh F., Rezakhanlou A.M., Hartwell R., Medina A., et al. Local expression of indoleamine 2,3 dioxygenase in syngeneic fibroblasts significantly prolongs survival of an engineered three-dimensional islet allograft. Diabetes 2010, 59:2219-2227.
21. Li Y., Tredget E.E., Ghaffari A., Lin X., Kilani R.T., et al. Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogenic skin substitute. J. Investig. Dermatol. 2006, 126:128-136.
22. Poormasjedi-Meibod M.S., Jalili R.B., Hosseini-Tabatabaei A., Hartwell R., Ghahary A. Immuno-regulatory function of indoleamine 2,3 dioxygenase through modulation of innate immune responses. PLoS One 2013, 8:e71044.
23. Maeda A., Kawamura T., Ueno T., Usui N., Miyagawa S. Monocytic suppressor cells derived from human peripheral blood suppress xenogenic immune reactions. Xenotransplantation 2014, 21:46-56.
24. Maeda A., Kawamura T., Nakahata K., Ueno T., Usui N., et al. Monocytic suppressor cells derived from peripheral blood suppress xenogenic natural killer cell lysis. Transplant. Proc. 2014, 46:1254-1255.
25. Munder M. Arginase: an emerging key player in the mammalian immune system. Br. J. Pharmacol. 2009, 158:638-651.
26. Edwards J.P., Zhang X., Frauwirth K.A., Mosser D.M. Biochemical and functional characterization of three activated macrophage populations. J. Leukoc. Biol. 2006, 80:1298-1307.
27. Morris S.M. Arginine metabolism: boundaries of our knowledge. J. Nutr. 2007, 137(Suppl. 2):1602S-1609S.
28. Morris S.M. Arginine: master and commander in innate immune responses. Sci. Signal. 2010, 3:pe27.
29. Melillo G., Cox G.W., Biragyn A., Sheffler L.A., Varesio L. Regulation of nitric-oxide synthetase mRNA expression by interferon-gamma and picolinic acid. J. Biol. Chem. 1994, 269:190-198.
30. Chiarugi A., Rovida E., Sbarba P.D., Moroni F. Tryptophan availability selectively limits NO-synthase induction in macrophages. J. Leukoc. Biol. 2003, 73:172-177.
31. Sekkai D., Guittet O., Lemaire G., Tenu J.P., Lepoivre M. Inhibition of nitric oxide synthase expression and activity in macrophages by 3-hydroxyanthranilic acid, a tryptophan metabolite. Arch. Biochem. Biophys. 1997, 340:117-123.