Automated 3-dimensional morphologic analysis of sputum specimens for lung cancer detection: Performance characteristics support use in lung cancer screening

Cancer Cytopathology

Volumn 123, Issue 9, 2015, Pages 548-556

  Wilbur, David C ^a   Meyer, Michael G ^a   Presley, Chris ^a   Aye, Ralph W ^b   Zarogoulidis, Paul ^c   Johnson, Douglas W ^d   Peled, Nir ^e   Nelson, Alan C ^a  

^a VisionGate Inc   (United States)

^b SWEDISH MEDICAL CENTER   (United States)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^d Baptist Cancer Institute   (United States)

^e RABIN MEDICAL CENTER   (Israel)

Author keywords

automation; Cell CT; cytology; LuCED; lung cancer; screening

Indexed keywords

ARTICLE; CANCER DIAGNOSIS; CANCER SCREENING; CANCER STAGING; CELL STRUCTURE; CLASSIFIER; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC KIT; DIAGNOSTIC VALUE; EPITHELIUM CELL; FALSE NEGATIVE RESULT; HUMAN; LUNG ADENOCARCINOMA; LUNG CANCER; NON INVASIVE MEASUREMENT; NON SMALL CELL LUNG CANCER; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SMALL CELL LUNG CANCER; SPUTUM CYTODIAGNOSIS; SQUAMOUS CELL LUNG CARCINOMA; TUMOR LOCALIZATION; TUMOR VOLUME; AGED; AUTOMATION; COHORT ANALYSIS; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CYTODIAGNOSIS; CYTOLOGY; EARLY DIAGNOSIS; FEMALE; LUNG TUMOR; MALE; MIDDLE AGED; PATHOLOGY; PROCEDURES; RADIOGRAPHY; SPUTUM; TASK PERFORMANCE; THREE DIMENSIONAL IMAGING; TUMOR INVASION;

AGED; AUTOMATION; COHORT STUDIES; CYTODIAGNOSIS; EARLY DETECTION OF CANCER; EPITHELIAL CELLS; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; SENSITIVITY AND SPECIFICITY; SPUTUM; TASK PERFORMANCE AND ANALYSIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84943597875     PISSN: 1934662X     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.21565     Document Type: Article

References (17)

1. Wilbur DC, Prey MU, Miller WM, Pawlick GF, Colgan TJ,. The AutoPap system for primary screening in cervical cytology. Comparing the results of a prospective, intended-use study with routine manual practice. Acta Cytol. 1998; 42: 214-220.
2. Wilbur DC, Black-Schaffer WS, Luff RD, et al., The Becton Dickinson FocalPoint GS Imaging System: clinical trials demonstrate significantly improved sensitivity for the detection of important cervical lesions. Am J Clin Pathol. 2009; 132: 767-775.
3. Meyer M, Hayenga J, Neumann T, et al., The Cell-CT 3D cell imaging technology platform enables the detection of lung cancer using the non-invasive LuCED Sputum Test. Cancer (Cancer Cytopathol). 2015; 123: 512-523.
4. American Cancer Society. Cancer Facts and Figures 2015. Atlanta, GA: American Cancer Society; 2015. Available at: http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf. Accessed March 10, 2015.
5. Pilotti S, Rilke F, Gribaudi G, Ravasi GL,. Sputum cytology for the diagnosis of carcinoma of the lung. Acta Cytol. 1982; 26: 649-654.
6. Sing A, Freudenberg N, Kortsik C, Wertzel H, Klosa B, Hasse J,. Comparison of the sensitivity of sputum and brush cytology in the diagnosis of lung carcinomas. Acta Cytol. 1997; 41: 399-408.
7. Van Rensburg A, Neethling GS, Schubert PT, et al., Impact of routine sputum cytology in a population at high risk for bronchial carcinoma. Int J Tuberc Lung Dis. 2014; 18: 607-612.
8. Centers for Medicare & Medicaid Services. National coverage determination (NCD) for screening for lung cancer with low dose computed tomography (LDCT) [press release]. Baltimore, MD: Centers for Medicare and Medicaid Services; February 5, 2015. Available at: http://www.cms.gov/Newsroom/MediaReleaseDatabase/Press-releases/2015-Press-releases-items/2015-02-05.html. Accessed March 10, 2015.
9. Radiology Info.org. Lung Cancer Screening. Oakbrook, IL: Radiologic Society of North America/American College of Radiology; 2015. Available at: http://www.radiologyinfo.org/en/info.cfm?pg=screening-lung. Accessed March 10, 2015.
10. Moyer VA,; U.S. Preventive Services Task Force. Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014; 160: 330-338.
11. National Lung Screening Trial Research Team, Aberle DR, Adams AM, et al., Reduced lung-cancer mortality with low-dose computed tomographic scanning. N Engl J Med. 2011; 365: 395-409.
12. Bach PB, Mirkin JN, Oliver TK, et al., Benefits and harms of CT screening for lung cancer: a systematic review. JAMA. 2012; 307: 2418-2429.
13. Clopper CJ, Pearson ES,. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika. 1934; 26: 404-413.
14. Kim JJ, Wright TC, Goldie SJ,. Cost-effectiveness of alternative triage strategies for atypical squamous cells of undetermined significance. JAMA. 2002; 287: 2382-2390.
15. Pinsky PF, Gierada DS, Black W, et al., Performance of Lung-RADS in the National Lung Screening Trial: a retrospective assessment. Ann Intern Med. 2015; 162: 485-491.
16. Bocking A, Biesterfeld S, Chatelain R, Gien-Gerlach G, Esser E,. Diagnosis of bronchial carcinoma on sections of paraffin-embedded sputum. Sensitivity and specificity of an alternative to routine cytology. Acta Cytol. 1992; 36: 37-47.
17. Idowu MO, Powers CN,. Lung cancer cytology: potential pitfalls and mimics-a review. Int J Clin Exp Pathol. 2010; 3: 367-385.