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Volumn 121, Issue 20, 2015, Pages 3600-3611

Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma

Author keywords

epidermal growth factor receptor (EGFR); head and neck cancer; heregulin; human epidermal growth factor receptor 3 (HER3); human papillomavirus

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NEU DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB2 PROTEIN, HUMAN; ERBB3 PROTEIN, HUMAN; GENETIC MARKER; NRG1 PROTEIN, HUMAN; P16 PROTEIN, HUMAN; TUMOR PROTEIN;

EID: 84943580009     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.29549     Document Type: Article
Times cited : (43)

References (48)
  • 2
    • 80052570003 scopus 로고    scopus 로고
    • Gender and ethnic disparities in incidence and survival of squamous cell carcinoma of the oral tongue, base of tongue, and tonsils: A Surveillance, Epidemiology and End Results program-based analysis
    • Saba NF, Goodman M, Ward K, et al., Gender and ethnic disparities in incidence and survival of squamous cell carcinoma of the oral tongue, base of tongue, and tonsils: a Surveillance, Epidemiology and End Results program-based analysis. Oncology. 2011; 81: 12-20.
    • (2011) Oncology , vol.81 , pp. 12-20
    • Saba, N.F.1    Goodman, M.2    Ward, K.3
  • 3
    • 80052565730 scopus 로고    scopus 로고
    • Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    • Chaturvedi AK, Engels EA, Pfeiffer RM, et al., Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011; 29: 4294-4301.
    • (2011) J Clin Oncol , vol.29 , pp. 4294-4301
    • Chaturvedi, A.K.1    Engels, E.A.2    Pfeiffer, R.M.3
  • 4
    • 80053435324 scopus 로고    scopus 로고
    • The role of HPV in head and neck cancer and review of the HPV vaccine
    • D'Souza G, Dempsey A,. The role of HPV in head and neck cancer and review of the HPV vaccine. Prev Med. 2011; 53 (suppl 1): S5-S11.
    • (2011) Prev Med , vol.53 , pp. S5-S11
    • D'Souza, G.1    Dempsey, A.2
  • 5
    • 0034600339 scopus 로고    scopus 로고
    • Evidence for a causal association between human papillomavirus and a subset of head and neck cancers
    • Gillison ML, Koch WM, Capone RB, et al., Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000; 92: 709-720.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 709-720
    • Gillison, M.L.1    Koch, W.M.2    Capone, R.B.3
  • 6
    • 51649093834 scopus 로고    scopus 로고
    • Recent advances in head and neck cancer
    • Haddad RI, Shin DM,. Recent advances in head and neck cancer. N Engl J Med. 2008; 359: 1143-1154.
    • (2008) N Engl J Med , vol.359 , pp. 1143-1154
    • Haddad, R.I.1    Shin, D.M.2
  • 7
    • 77954190940 scopus 로고    scopus 로고
    • Human papillomavirus and survival of patients with oropharyngeal cancer
    • Ang KK, Harris J, Wheeler R, et al., Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010; 363: 24-35.
    • (2010) N Engl J Med , vol.363 , pp. 24-35
    • Ang, K.K.1    Harris, J.2    Wheeler, R.3
  • 8
    • 84875421186 scopus 로고    scopus 로고
    • Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    • O'Sullivan B, Huang SH, Siu LL, et al., Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol. 2013; 31: 543-550.
    • (2013) J Clin Oncol , vol.31 , pp. 543-550
    • O'Sullivan, B.1    Huang, S.H.2    Siu, L.L.3
  • 9
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities
    • Yarden Y,. The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities. Eur J Cancer. 2001; 37 (suppl 4): S3-S8.
    • (2001) Eur J Cancer , vol.37 , pp. S3-S8
    • Yarden, Y.1
  • 10
    • 84861495556 scopus 로고    scopus 로고
    • Therapeutic targeting of the epidermal growth factor receptor in human cancer
    • Dhomen NS, Mariadason J, Tebbutt N, Scott AM,. Therapeutic targeting of the epidermal growth factor receptor in human cancer. Crit Rev Oncog. 2012; 17: 31-50.
    • (2012) Crit Rev Oncog , vol.17 , pp. 31-50
    • Dhomen, N.S.1    Mariadason, J.2    Tebbutt, N.3    Scott, A.M.4
  • 11
    • 80054747872 scopus 로고    scopus 로고
    • Resistance to EGFR-targeted therapy: A family affair
    • Vlacich G, Coffey RJ,. Resistance to EGFR-targeted therapy: a family affair. Cancer Cell. 2011; 20: 423-425.
    • (2011) Cancer Cell , vol.20 , pp. 423-425
    • Vlacich, G.1    Coffey, R.J.2
  • 12
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J,. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol. 2002; 2D (suppl 18): 1S-13S.
    • (2002) J Clin Oncol , vol.2 D , pp. 1S-13S
    • Mendelsohn, J.1
  • 13
    • 84876074689 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in head and neck cancer: Have we been just skimming the surface?
    • Hansen AR, Siu LL,. Epidermal growth factor receptor targeting in head and neck cancer: have we been just skimming the surface? J Clin Oncol. 2013; 31: 1381-1383.
    • (2013) J Clin Oncol , vol.31 , pp. 1381-1383
    • Hansen, A.R.1    Siu, L.L.2
  • 14
    • 84875734469 scopus 로고    scopus 로고
    • Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: Analysis of data from the EXTREME and CRYSTAL studies
    • Licitra L, Storkel S, Kerr KM, et al., Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies. Eur J Cancer. 2013; 49: 1161-1168.
    • (2013) Eur J Cancer , vol.49 , pp. 1161-1168
    • Licitra, L.1    Storkel, S.2    Kerr, K.M.3
  • 15
    • 65449131740 scopus 로고    scopus 로고
    • The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
    • Kong CS, Narasimhan B, Cao H, et al., The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2009; 74: 553-561.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , pp. 553-561
    • Kong, C.S.1    Narasimhan, B.2    Cao, H.3
  • 16
    • 49249095295 scopus 로고    scopus 로고
    • EGFR, p16, HPV titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    • Kumar B, Cordell KG, Lee JS, et al., EGFR, p16, HPV titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol. 2008; 26: 3128-3137.
    • (2008) J Clin Oncol , vol.26 , pp. 3128-3137
    • Kumar, B.1    Cordell, K.G.2    Lee, J.S.3
  • 17
    • 77954213063 scopus 로고    scopus 로고
    • Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer
    • Hong A, Dobbins T, Lee CS, et al., Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer. Eur J Cancer. 2010; 46: 2088-2096.
    • (2010) Eur J Cancer , vol.46 , pp. 2088-2096
    • Hong, A.1    Dobbins, T.2    Lee, C.S.3
  • 18
    • 84876746241 scopus 로고    scopus 로고
    • EGFR and phosphorylated EGFR in relation to HPV and clinical outcome in tonsillar cancer
    • Romanitan M, Nasman A, Munck-Wikland E, Dalianis T, Ramqvist T,. EGFR and phosphorylated EGFR in relation to HPV and clinical outcome in tonsillar cancer. Anticancer Res. 2013; 33: 1575-1583.
    • (2013) Anticancer Res , vol.33 , pp. 1575-1583
    • Romanitan, M.1    Nasman, A.2    Munck-Wikland, E.3    Dalianis, T.4    Ramqvist, T.5
  • 19
    • 84875990922 scopus 로고    scopus 로고
    • The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species
    • Spangle JM, Munger K,. The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species. PLoS Pathog. 2013; 9: e1003237.
    • (2013) PLoS Pathog , vol.9 , pp. e1003237
    • Spangle, J.M.1    Munger, K.2
  • 20
    • 34548611498 scopus 로고    scopus 로고
    • Role of heregulin in human cancer
    • Breuleux M,. Role of heregulin in human cancer. Cell Mol Life Sci. 2007; 64: 2358-2377.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2358-2377
    • Breuleux, M.1
  • 21
    • 0033009389 scopus 로고    scopus 로고
    • Binding specificities and affinities of egf domains for ErbB receptors
    • Jones JT, Akita RW, Sliwkowski MX,. Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett. 1999; 447: 227-231.
    • (1999) FEBS Lett , vol.447 , pp. 227-231
    • Jones, J.T.1    Akita, R.W.2    Sliwkowski, M.X.3
  • 22
    • 0031705405 scopus 로고    scopus 로고
    • ErbB tyrosine kinases and the 2 neuregulin families constitute a ligand-receptor network
    • Pinkas-Kramarski R, Shelly M, Guarino BC, et al., ErbB tyrosine kinases and the 2 neuregulin families constitute a ligand-receptor network. Mol Cell Biol. 1998; 18: 6090-6101.
    • (1998) Mol Cell Biol , vol.18 , pp. 6090-6101
    • Pinkas-Kramarski, R.1    Shelly, M.2    Guarino, B.C.3
  • 24
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • Citri A, Skaria KB, Yarden Y,. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res. 2003; 284: 54-65.
    • (2003) Exp Cell Res , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 25
    • 80052591747 scopus 로고    scopus 로고
    • Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
    • Yonesaka K, Zejnullahu K, Okamoto I, et al., Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011; 3: 99ra86.
    • (2011) Sci Transl Med , vol.3 , pp. 99ra86
    • Yonesaka, K.1    Zejnullahu, K.2    Okamoto, I.3
  • 26
    • 84899808225 scopus 로고    scopus 로고
    • ERBB3/HER2 signaling promotes resistance to EGFR blockade in head and neck and colorectal cancer models
    • Zhang L, Castanaro C, Luan B, et al., ERBB3/HER2 signaling promotes resistance to EGFR blockade in head and neck and colorectal cancer models. Mol Cancer Ther. 2014; 13: 1345-1355.
    • (2014) Mol Cancer Ther , vol.13 , pp. 1345-1355
    • Zhang, L.1    Castanaro, C.2    Luan, B.3
  • 27
    • 84904209728 scopus 로고    scopus 로고
    • Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma
    • Jiang N, Wang D, Hu Z, et al., Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma. Mol Cancer Ther. 2014; 13: 1826-1836.
    • (2014) Mol Cancer Ther , vol.13 , pp. 1826-1836
    • Jiang, N.1    Wang, D.2    Hu, Z.3
  • 28
    • 84874544754 scopus 로고    scopus 로고
    • High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck
    • Shames DS, Carbon J, Walter K, et al., High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck. PLoS One. 2013; 8: e56765.
    • (2013) PLoS One , vol.8 , pp. e56765
    • Shames, D.S.1    Carbon, J.2    Walter, K.3
  • 29
    • 84911486181 scopus 로고    scopus 로고
    • A phase II randomized open-label study of MM-121, a fully human monoclonal antibody targeting ERBB3, in combination with weekly paclitaxel versus weekly paclitaxel in patients with platinum-resistant/refractory ovarian cancers [abstract]
    • Abstract 5519
    • Liu J, Ray-Coquard IL, Selle F, et al., A phase II randomized open-label study of MM-121, a fully human monoclonal antibody targeting ERBB3, in combination with weekly paclitaxel versus weekly paclitaxel in patients with platinum-resistant/refractory ovarian cancers [abstract]. J Clin Oncol. 2014; 32 (suppl):Abstract 5519.
    • (2014) J Clin Oncol , vol.32
    • Liu, J.1    Ray-Coquard, I.L.2    Selle, F.3
  • 30
    • 84921741159 scopus 로고    scopus 로고
    • A randomized, double-blind phase II trial of exemestane plus MM-121 (a monoclonal antibody targeting ERBB3) or placebo in postmenopausal women with locally advanced or metastatic ER+/PR+, HER2-negative breast cancer [abstract]
    • Abstract 587
    • Higgins MJ, Doyle C, Paepke S, et al., A randomized, double-blind phase II trial of exemestane plus MM-121 (a monoclonal antibody targeting ERBB3) or placebo in postmenopausal women with locally advanced or metastatic ER+/PR+, HER2-negative breast cancer [abstract]. J Clin Oncol. 2014 32 (suppl):Abstract 587.
    • (2014) J Clin Oncol , vol.32
    • Higgins, M.J.1    Doyle, C.2    Paepke, S.3
  • 31
    • 84906718818 scopus 로고    scopus 로고
    • A randomized phase 2 trial of MM-121, a fully human monoclonal antibody targeting ErbB3, in combination with erlotinib, in EGFR wild-type NSCLC patients [abstract]
    • Abstract 8051
    • Sequist LV, Lopez-Chavez A, Doebele RC, et al., A randomized phase 2 trial of MM-121, a fully human monoclonal antibody targeting ErbB3, in combination with erlotinib, in EGFR wild-type NSCLC patients [abstract]. J Clin Oncol. 2014; 32 (suppl):Abstract 8051.
    • (2014) J Clin Oncol , vol.32
    • Sequist, L.V.1    Lopez-Chavez, A.2    Doebele, R.C.3
  • 32
    • 84976212862 scopus 로고    scopus 로고
    • Phase 2 HERALD study of patritumab (P) with erlotinib (E) in advanced NSCLC subjects (SBJs) [abstract]
    • Abstract 8045
    • Von Pawel J, Tseng J, Dediu M, et al., Phase 2 HERALD study of patritumab (P) with erlotinib (E) in advanced NSCLC subjects (SBJs) [abstract]. J Clin Oncol. 2014; 32 (suppl):Abstract 8045.
    • (2014) J Clin Oncol , vol.32
    • Von Pawel, J.1    Tseng, J.2    Dediu, M.3
  • 33
    • 84943587631 scopus 로고    scopus 로고
    • A meta-analysis of biomarkers in 3 randomized, phase 2 studies of MM-121, a ligand-blocking anti-ErbB3 antibody, in patients with ovarian, lung, and breast cancers
    • MacBeath G, Adiwijaya B, Liu J, et al., A meta-analysis of biomarkers in 3 randomized, phase 2 studies of MM-121, a ligand-blocking anti-ErbB3 antibody, in patients with ovarian, lung, and breast cancers. Ann Oncol. 2014; 25: iv58-iv84.
    • (2014) Ann Oncol , vol.25 , pp. iv58-iv84
    • MacBeath, G.1    Adiwijaya, B.2    Liu, J.3
  • 34
    • 84884514632 scopus 로고    scopus 로고
    • Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients
    • Onsum MD, Geretti E, Paragas V, et al., Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients. Am J Pathol. 2013; 183: 1446-1460.
    • (2013) Am J Pathol , vol.183 , pp. 1446-1460
    • Onsum, M.D.1    Geretti, E.2    Paragas, V.3
  • 35
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, et al., The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012; 2: 401-404.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 36
    • 84943585794 scopus 로고    scopus 로고
    • National Cancer Institute. Accessed May 9
    • National Cancer Institute. Available at: https://wiki.nci.nih.gov/display/TCGA/RNASeq+Version+2. Accessed May 9, 2013.
    • (2013)
  • 37
    • 84864117690 scopus 로고    scopus 로고
    • P16 immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma
    • Lewis JS Jr,. p16 immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma. Head Neck Pathol. 2012; 6 (suppl 1): S75-S82.
    • (2012) Head Neck Pathol , vol.6 , pp. S75-S82
    • Lewis, J.S.1
  • 38
    • 16344363218 scopus 로고    scopus 로고
    • Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth
    • Gregory CW, Whang YE, McCall W, et al., Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. Clin Cancer Res. 2005; 11: 1704-1712.
    • (2005) Clin Cancer Res , vol.11 , pp. 1704-1712
    • Gregory, C.W.1    Whang, Y.E.2    McCall, W.3
  • 39
    • 0036190848 scopus 로고    scopus 로고
    • Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma
    • Khan AJ, King BL, Smith BD, et al., Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma. Clin Cancer Res. 2002; 8: 540-548.
    • (2002) Clin Cancer Res , vol.8 , pp. 540-548
    • Khan, A.J.1    King, B.L.2    Smith, B.D.3
  • 40
    • 84943586798 scopus 로고    scopus 로고
    • Prognostic value of VEGFC, HER2 and HER3 gene expression in recurrent squamous cell head and neck tumors
    • (suppl):Abstract
    • Fountzilas G, Angouridakis N, Wirtz RM, Claas S, Nikolaou A, Kalogeras KT,. Prognostic value of VEGFC, HER2 and HER3 gene expression in recurrent squamous cell head and neck tumors. J Clin Oncol. 2006; 24 (suppl):Abstract 5538.
    • (2006) J Clin Oncol , vol.24 , pp. 5538
    • Fountzilas, G.1    Angouridakis, N.2    Wirtz, R.M.3    Claas, S.4    Nikolaou, A.5    Kalogeras, K.T.6
  • 41
    • 79960885569 scopus 로고    scopus 로고
    • Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma
    • Takikita M, Xie R, Chung JY, et al., Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma. J Transl Med. 2011; 9: 126.
    • (2011) J Transl Med , vol.9 , pp. 126
    • Takikita, M.1    Xie, R.2    Chung, J.Y.3
  • 43
    • 84892737015 scopus 로고    scopus 로고
    • Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation
    • Lee CY, Lin Y, Bratman SV, et al., Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation. Cancer Res. 2014; 74: 341-352.
    • (2014) Cancer Res , vol.74 , pp. 341-352
    • Lee, C.Y.1    Lin, Y.2    Bratman, S.V.3
  • 44
    • 84886048317 scopus 로고    scopus 로고
    • HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4)
    • Sollome JJ, Thavathiru E, Camenisch TD, Vaillancourt RR,. HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal. 2014; 26: 70-82.
    • (2014) Cell Signal , vol.26 , pp. 70-82
    • Sollome, J.J.1    Thavathiru, E.2    Camenisch, T.D.3    Vaillancourt, R.R.4
  • 45
    • 84884170935 scopus 로고    scopus 로고
    • An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
    • Xia W, Petricoin EF 3rd, Zhao S, et al., An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. Breast Cancer Res. 2013; 15: R85.
    • (2013) Breast Cancer Res , vol.15 , pp. R85
    • Xia, W.1    Petricoin, E.F.2    Zhao, S.3
  • 46
    • 84871298461 scopus 로고    scopus 로고
    • Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinoma
    • Husain H, Psyrri A, Markovic A, et al., Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinoma. Laryngoscope. 2012; 122: 2762-2768.
    • (2012) Laryngoscope , vol.122 , pp. 2762-2768
    • Husain, H.1    Psyrri, A.2    Markovic, A.3
  • 47
    • 84896766537 scopus 로고    scopus 로고
    • Impact of human papilloma virus infection on the response of head and neck cancers to anti-epidermal growth factor receptor antibody therapy
    • Pogorzelski M, Ting S, Gauler TC, et al., Impact of human papilloma virus infection on the response of head and neck cancers to anti-epidermal growth factor receptor antibody therapy. Cell Death Dis. 2014; 5: e1091.
    • (2014) Cell Death Dis , vol.5 , pp. e1091
    • Pogorzelski, M.1    Ting, S.2    Gauler, T.C.3
  • 48
    • 84943587427 scopus 로고    scopus 로고
    • Differential expression of EGFR, HER2, P16, and high-risk (hr) HPV status in oropharyngeal (Or) and oral cavity (OC) squamous cell carcinoma (SCC) [abstract]
    • Abstract 5521
    • Sudaka A, Saada E, Natale R, et al., Differential expression of EGFR, HER2, P16, and high-risk (hr) HPV status in oropharyngeal (Or) and oral cavity (OC) squamous cell carcinoma (SCC) [abstract]. J Clin Oncol. 2012; 30 (suppl):Abstract 5521.
    • (2012) J Clin Oncol , vol.30
    • Sudaka, A.1    Saada, E.2    Natale, R.3


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