메뉴 건너뛰기




Volumn 13, Issue 1, 2015, Pages

PCSK9 inhibition: The way forward in the treatment of dyslipidemia

Author keywords

Cholesterol lowering drugs; LDL cholesterol; PCSK9

Indexed keywords

ALIROCUMAB; BOCOCIZUMAB; EVOLOCUMAB; EZETIMIBE; KEXIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PROTEIN PCSK9; UNCLASSIFIED DRUG; HYPOCHOLESTEROLEMIC AGENT; PCSK9 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 9; PROTEINASE INHIBITOR; SERINE PROTEINASE;

EID: 84943575922     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-015-0503-4     Document Type: Review
Times cited : (34)

References (42)
  • 1
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-9.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 2
    • 84931411520 scopus 로고    scopus 로고
    • IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes
    • Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, et al. IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372:2387-97.
    • (2015) N Engl J Med , vol.372 , pp. 2387-2397
    • Cannon, C.P.1    Blazing, M.A.2    Giugliano, R.P.3    McCagg, A.4    White, J.A.5    Theroux, P.6
  • 3
    • 36348975228 scopus 로고    scopus 로고
    • ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, et al. ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109-22.
    • (2007) N Engl J Med , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3    Grundy, S.M.4    Kastelein, J.J.5    Komajda, M.6
  • 5
    • 84904252744 scopus 로고    scopus 로고
    • Effects of extended-release niacin with laropiprant in high-risk patients
    • HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, et al. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med. 2014;371:203-12.
    • (2014) N Engl J Med , vol.371 , pp. 203-212
    • Landray, M.J.1    Haynes, R.2    Hopewell, J.C.3    Parish, S.4    Aung, T.5
  • 6
    • 84870045994 scopus 로고    scopus 로고
    • dal-OUTCOMES Investigators. Effects of dalcetrapib in patients with a recent acute coronary syndrome
    • Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, et al. dal-OUTCOMES Investigators. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367:2089-99.
    • (2012) N Engl J Med , vol.367 , pp. 2089-2099
    • Schwartz, G.G.1    Olsson, A.G.2    Abt, M.3    Ballantyne, C.M.4    Barter, P.J.5    Brumm, J.6
  • 7
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, Crouse 3rd JR, Leiter LA, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362:1563-74.
    • (2010) N Engl J Med , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3    Crouse, J.R.4    Leiter, L.A.5
  • 8
    • 28044452217 scopus 로고    scopus 로고
    • FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    • Keech A, Simes RJ, Barter P, Best J, Scott R, Taskinen MR, et al. FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005;366:1849-61.
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3    Best, J.4    Scott, R.5    Taskinen, M.R.6
  • 9
    • 84902576469 scopus 로고    scopus 로고
    • American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2889-934.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2889-2934
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 10
    • 57649211987 scopus 로고    scopus 로고
    • Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel
    • Chodick G, Shalev V, Gerber Y, Heymann AD, Silber H, Simah V, et al. Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel. Clin Ther. 2008;30:2167-79.
    • (2008) Clin Ther , vol.30 , pp. 2167-2179
    • Chodick, G.1    Shalev, V.2    Gerber, Y.3    Heymann, A.D.4    Silber, H.5    Simah, V.6
  • 11
    • 77049105368 scopus 로고    scopus 로고
    • Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands
    • Pijlman AH, Huijgen R, Verhagen SN, Imholz BP, Liem AH, Kastelein JJ, et al. Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands. Atherosclerosis. 2010;209:189-94.
    • (2010) Atherosclerosis , vol.209 , pp. 189-194
    • Pijlman, A.H.1    Huijgen, R.2    Verhagen, S.N.3    Imholz, B.P.4    Liem, A.H.5    Kastelein, J.J.6
  • 14
    • 84904525083 scopus 로고    scopus 로고
    • Living the PCSK9 adventure: from the identification of a new gene in familial hypercholesterolemia towards a potential new class of anticholesterol drugs
    • Abifadel M, Elbitar S, El Khoury P, Ghaleb Y, Chemaly M, Moussalli ML, et al. Living the PCSK9 adventure: from the identification of a new gene in familial hypercholesterolemia towards a potential new class of anticholesterol drugs. Curr Atheroscler Rep. 2014;16:439.
    • (2014) Curr Atheroscler Rep , vol.16 , pp. 439
    • Abifadel, M.1    Elbitar, S.2    Khoury, P.3    Ghaleb, Y.4    Chemaly, M.5    Moussalli, M.L.6
  • 15
    • 84892741671 scopus 로고    scopus 로고
    • Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
    • Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, et al. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet. 2014;383:60-8.
    • (2014) Lancet , vol.383 , pp. 60-68
    • Fitzgerald, K.1    Frank-Kamenetsky, M.2    Shulga-Morskaya, S.3    Liebow, A.4    Bettencourt, B.R.5    Sutherland, J.E.6
  • 16
    • 64849093564 scopus 로고    scopus 로고
    • Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor
    • Duff CJ, Scott MJ, Kirby IT, Hutchinson SE, Martin SL, Hooper NM. Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J. 2009;419:577-84.
    • (2009) Biochem J , vol.419 , pp. 577-584
    • Duff, C.J.1    Scott, M.J.2    Kirby, I.T.3    Hutchinson, S.E.4    Martin, S.L.5    Hooper, N.M.6
  • 18
    • 84925351969 scopus 로고    scopus 로고
    • Lipid lowering with PCSK9 inhibitors
    • Dadu RT, Ballantyne CM. Lipid lowering with PCSK9 inhibitors. Nat Rev Cardiol. 2014;11:563-75.
    • (2014) Nat Rev Cardiol , vol.11 , pp. 563-575
    • Dadu, R.T.1    Ballantyne, C.M.2
  • 19
    • 84931849550 scopus 로고    scopus 로고
    • Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis
    • Navarese EP, Kolodziejczak M, Schulze V, Gurbel PA, Tantry U, Lin Y, et al. Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis. Ann Intern Med. 2015;163:40-51.
    • (2015) Ann Intern Med , vol.163 , pp. 40-51
    • Navarese, E.P.1    Kolodziejczak, M.2    Schulze, V.3    Gurbel, P.A.4    Tantry, U.5    Lin, Y.6
  • 20
    • 84935001755 scopus 로고    scopus 로고
    • Safety and efficacy of anti-PCSK9 antibodies: a meta-analysis of 25 randomized, controlled trials
    • Zhang XL, Zhu QQ, Zhu L, Chen JZ, Chen QH, Li GN, et al. Safety and efficacy of anti-PCSK9 antibodies: a meta-analysis of 25 randomized, controlled trials. BMC Med. 2015;13:123.
    • (2015) BMC Med , vol.13 , pp. 123
    • Zhang, X.L.1    Zhu, Q.Q.2    Zhu, L.3    Chen, J.Z.4    Chen, Q.H.5    Li, G.N.6
  • 21
    • 84926206074 scopus 로고    scopus 로고
    • Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • Sabatine MS, Giugliano RP, Wiviott SD, Raal FJ, Blom DJ, Robinson J, et al. Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015;372:1500-9.
    • (2015) N Engl J Med , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1    Giugliano, R.P.2    Wiviott, S.D.3    Raal, F.J.4    Blom, D.J.5    Robinson, J.6
  • 22
    • 84927578440 scopus 로고    scopus 로고
    • Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia
    • Ballantyne CM, Neutel J, Cropp A, Duggan W, Wang EQ, Plowchalk D, et al. Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia. Am J Cardiol. 2015;115:1212-21.
    • (2015) Am J Cardiol , vol.115 , pp. 1212-1221
    • Ballantyne, C.M.1    Neutel, J.2    Cropp, A.3    Duggan, W.4    Wang, E.Q.5    Plowchalk, D.6
  • 23
    • 84926191670 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
    • Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015;372:1489-99.
    • (2015) N Engl J Med , vol.372 , pp. 1489-1499
    • Robinson, J.G.1    Farnier, M.2    Krempf, M.3    Bergeron, J.4    Luc, G.5    Averna, M.6
  • 24
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376:1670-81.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4    Reith, C.5
  • 25
    • 84905189482 scopus 로고    scopus 로고
    • Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials
    • Boekholdt SM, Hovingh GK, Mora S, Arsenault BJ, Amarenco P, Pedersen TR, et al. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials. J Am College Cardiol. 2014;64:485-94.
    • (2014) J Am College Cardiol , vol.64 , pp. 485-494
    • Boekholdt, S.M.1    Hovingh, G.K.2    Mora, S.3    Arsenault, B.J.4    Amarenco, P.5    Pedersen, T.R.6
  • 26
    • 84943534243 scopus 로고    scopus 로고
    • FDA approves Praluent to treat certain patients with high cholesterol
    • Last accessed 30-09
    • US Food and Drug Administration. FDA News Release. FDA approves Praluent to treat certain patients with high cholesterol. First in a new class of injectable cholesterol-lowering drugs. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm455883.htm. Last accessed 30-09-2015.
    • (2015) First in a new class of injectable cholesterol-lowering drugs
  • 27
    • 84943538637 scopus 로고    scopus 로고
    • Praluent recommended for approval to lower cholesterol
    • Medicine to offer therapy for patients unable to control high cholesterol with currently available treatment. Last accessed 30-09-2015.
    • European Medicines Agency. Praluent recommended for approval to lower cholesterol. Medicine to offer therapy for patients unable to control high cholesterol with currently available treatment http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/07/news_detail_002377.jsp&mid=WC0b01ac058004d5c1. Last accessed 30-09-2015.
  • 29
    • 84861747780 scopus 로고    scopus 로고
    • Understanding Statin Use in America and Gaps in Patient Education (USAGE): an internet-based survey of 10,138 current and former statin users
    • Cohen JD, Brinton EA, Ito MK, Jacobson TA. Understanding Statin Use in America and Gaps in Patient Education (USAGE): an internet-based survey of 10,138 current and former statin users. J Clin Lipidol. 2012;6:208-15.
    • (2012) J Clin Lipidol , vol.6 , pp. 208-215
    • Cohen, J.D.1    Brinton, E.A.2    Ito, M.K.3    Jacobson, T.A.4
  • 30
    • 84902157271 scopus 로고    scopus 로고
    • Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab
    • Stroes E, Colquhoun D, Sullivan D, Civeira F, Rosenson RS, Watts GF, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol. 2014;63:2541-8.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2541-2548
    • Stroes, E.1    Colquhoun, D.2    Sullivan, D.3    Civeira, F.4    Rosenson, R.S.5    Watts, G.F.6
  • 31
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial
    • Sullivan D, Olsson AG, Scott R, Kim JB, Xue A, Gebski V, et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA. 2012;308:2497-506.
    • (2012) JAMA , vol.308 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3    Kim, J.B.4    Xue, A.5    Gebski, V.6
  • 32
    • 84943563812 scopus 로고    scopus 로고
    • ODYSSEY ALTERNATIVE: Efficacy and safety of alirocumab versus ezetimibe, in patients with statin intolerance as defined by a placebo run-in and statin rechallenge arm.
    • ODYSSEY ALTERNATIVE: Efficacy and safety of alirocumab versus ezetimibe, in patients with statin intolerance as defined by a placebo run-in and statin rechallenge arm. https://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_469684.pdf. Accessed 30 September 2015.
  • 33
    • 84927742065 scopus 로고    scopus 로고
    • Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management
    • Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, et al. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015;36:1012-22.
    • (2015) Eur Heart J , vol.36 , pp. 1012-1022
    • Stroes, E.S.1    Thompson, P.D.2    Corsini, A.3    Vladutiu, G.D.4    Raal, F.J.5    Ray, K.K.6
  • 34
    • 84906716305 scopus 로고    scopus 로고
    • Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
    • Cuchel M, Bruckert E, Ginsberg HN, Raal FJ, Santos RD, Hegele RA, et al. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J. 2014;35:2146-57.
    • (2014) Eur Heart J , vol.35 , pp. 2146-2157
    • Cuchel, M.1    Bruckert, E.2    Ginsberg, H.N.3    Raal, F.J.4    Santos, R.D.5    Hegele, R.A.6
  • 35
    • 84871945617 scopus 로고    scopus 로고
    • Phase 3 HoFH Lomitapide Study investigators. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
    • Cuchel M, Meagher EA, du Toit TH, Blom DJ, Marais AD, Hegele RA, et al. Phase 3 HoFH Lomitapide Study investigators. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet. 2013;381:40-6.
    • (2013) Lancet , vol.381 , pp. 40-46
    • Cuchel, M.1    Meagher, E.A.2    Toit, T.H.3    Blom, D.J.4    Marais, A.D.5    Hegele, R.A.6
  • 36
    • 77949485460 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
    • Raal FJ, Santos RD, Blom DJ, Marais AD, Charng MJ, Cromwell WC, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375:998-1006.
    • (2010) Lancet , vol.375 , pp. 998-1006
    • Raal, F.J.1    Santos, R.D.2    Blom, D.J.3    Marais, A.D.4    Charng, M.J.5    Cromwell, W.C.6
  • 37
    • 84927729932 scopus 로고    scopus 로고
    • The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia-A post-hoc analysis of a Phase 3, single-arm, open-label trial
    • Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron HD, Marais AD, et al. The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia-A post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis. 2015;240:408-14.
    • (2015) Atherosclerosis , vol.240 , pp. 408-414
    • Stefanutti, C.1    Blom, D.J.2    Averna, M.R.3    Meagher, E.A.4    Theron, H.D.5    Marais, A.D.6
  • 38
    • 84921459685 scopus 로고    scopus 로고
    • TESLA Investigators. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial
    • Raal FJ, Honarpour N, Blom DJ, Hovingh GK, Xu F, Scott R, et al. TESLA Investigators. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet. 2015;385:341-50.
    • (2015) Lancet , vol.385 , pp. 341-350
    • Raal, F.J.1    Honarpour, N.2    Blom, D.J.3    Hovingh, G.K.4    Xu, F.5    Scott, R.6
  • 39
    • 84931028781 scopus 로고    scopus 로고
    • Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010
    • Mundal L, Sarancic M, Ose L, Iversen PO, Borgan JK, Veierod MB, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010. J Am Heart Assoc. 2014;3:e001236.
    • (2014) J Am Heart Assoc , vol.3 , pp. e001236
    • Mundal, L.1    Sarancic, M.2    Ose, L.3    Iversen, P.O.4    Borgan, J.K.5    Veierod, M.B.6
  • 40
    • 84921483643 scopus 로고    scopus 로고
    • RUTHERFORD-2 Investigators. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
    • Raal FJ, Stein EA, Dufour R, Turner T, Civeira F, Burgess L, et al. RUTHERFORD-2 Investigators. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet. 2015;385:331-40.
    • (2015) Lancet , vol.385 , pp. 331-340
    • Raal, F.J.1    Stein, E.A.2    Dufour, R.3    Turner, T.4    Civeira, F.5    Burgess, L.6
  • 41
    • 84903754236 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies
    • Kastelein JJ, Robinson JG, Farnier M, Krempf M, Langslet G, Lorenzato C, et al. Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies. Cardiovasc Drugs Ther. 2014;28:281-9.
    • (2014) Cardiovasc Drugs Ther , vol.28 , pp. 281-289
    • Kastelein, J.J.1    Robinson, J.G.2    Farnier, M.3    Krempf, M.4    Langslet, G.5    Lorenzato, C.6
  • 42
    • 84963669487 scopus 로고    scopus 로고
    • ODYSSEY HIGH FH: efficacy and safety of alirocumab in patients with severe heterozygous familial hypercholesterolemia
    • Chicago, IL: AHA
    • Ginsberg HN. ODYSSEY HIGH FH: efficacy and safety of alirocumab in patients with severe heterozygous familial hypercholesterolemia. Chicago, IL: AHA; 2014. http://my.americanheart.org/idc/groups/ahamahpublic/@wcm/@sop/@scon/documents/downloadable/ucm_469616.pdf. Accessed 30 September 2015.
    • (2014)
    • Ginsberg, H.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.