Angelica sinensis polysaccharides inhibit endothelial progenitor cell senescence through the reduction of oxidative stress and activation of the Akt/hTERT pathway

Pharmaceutical Biology

Volumn 53, Issue 12, 2015, Pages 1842-1849

  Lai, Peng ^a   Liu, Yixin ^b  

^a XIHUA UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

EPCs; gp91 phox; ox LDL; Superoxide anion; Telomerase

Indexed keywords

POLYSACCHARIDE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; PLANT EXTRACT;

ANGELICA SINENSIS; ANIMAL CELL; ARTICLE; CELL AGING; CELL ISOLATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PLANT ROOT; SIGNAL TRANSDUCTION; WISTAR RAT;

ANGELICA SINENSIS; ANIMALS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL PROGENITOR CELLS; MALE; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT ROOTS; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TELOMERASE;

EID: 84943572909     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2015.1027779     Document Type: Article

References (33)

1. Asahara T, Murohara T, Sullivan A, et al. (1997). Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964-7.
2. Beausejour C. (2007). Bone marrow-derived cells: The influence of aging and cellular senescence. Handb Exp Pharmacol 180:67-88.
3. Burton DG. (2009). Cellular senescence, ageing and disease. Age 31:1-9.
4. Chen XP, Li W, Xiao XF, et al. (2013). Phytochemical and pharmacological studies on Radix Angelica sinensis. Chin J Nat Med 11:577-87.
5. Chen YH, Guh JY, Chuang TD, et al. (2007). High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway. Arch Biochem Biophys 465:164-71.
6. Dubois M, Gilles KA, Hamilton JK, et al. (1956). Colorimetric method for determination of sugars and related substances. Anal Chem 28:350-6.
7. Elnakish MT, Hassanain HH, Janssen PM, et al. (2013). Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: Important role of Rac/NADPH oxidase. J Pathol 231:290-300.
8. Gao D, Song J, Hu J, et al. (2005). Angiogenesis promoting effects of Chinese herbal medicine for activating blood circulation to remove stasis on chick embryo chorio-allantoic membrane. Zhongguo Zhong Xi Yi Jie He Za Zhi 25:912-15.
9. Imanishi T, Hano T, Nishio I. (2005). Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens 23:97-104.
10. Imanishi T, Hano T, Sawamura T, Nishio I. (2004). Oxidized lowdensity lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol 31:407-13.
11. Imanishi T, Kobayashi K, Kuroi A, et al. (2008a). Pioglitazone inhibits angiotensin II-induced senescence of endothelial progenitor cell. Hypertens Res 31:757-65.
12. Imanishi T, Tsujioka H, Akasaka T. (2008b). Endothelial progenitor cells dysfunction and senescence: Contribution to oxidative stress. Curr Cardiol Rev 4:275-86.
13. Krankel N, Luscher TF, Landmesser U. (2012). "Endothelial progenitor cells" as a therapeutic strategy in cardiovascular disease. Curr Vasc Pharmacol 10:107-24.
14. Lai P, Liu Y. (2014). Echinocystic acid, isolated from Gleditsia sinensis fruit, protects endothelial progenitor cells from damage caused by oxLDL via the Akt/eNOS pathway. Life Sci 114:62-9.
15. Lavoie JR, Stewart DJ. (2012). Genetically modified endothelial progenitor cells in the therapy of cardiovascular disease and pulmonary hypertension. Curr Vasc Pharmacol 10:289-99.
16. Lefèvre J, Michaud SÉ, Haddad P, et al. (2007). Moderate consumption of red wine (cabernet sauvignon) improves ischemia-induced neovascularization in ApoE-deficient mice: Effect on endothelial progenitor cells and nitric oxide. FASEB J 21:3845-52.
17. Libby P, Ridker PM, Hansson GK. (2011). Progress and challenges in translating the biology of atherosclerosis. Nature 473:317-25.
18. Liu Y, Wei J, Hu S, Hu L. (2012). Beneficial effects of statins on endothelial progenitor cells. Am J Med Sci 344:220-6.
19. Minamino T, Komuro I. (2008). Role of telomeres in vascular senescence. Front Biosci 13:2971-9.
20. Morel O, Jesel L, Abbas M, Morel N. (2013). Prothrombotic changes in diabetes mellitus. Semin Thromb Hemost 39:477-88.
21. Natesan S. (2005). Telomerase extends a helping hand to progenitor cells. Trends Biotechnol 23:1-3.
22. Nicholls C, Li H, Wang JQ, Liu JP. (2011). Molecular regulation of telomerase activity in aging. Protein Cell 2:726-38.
23. Paneni F, Osto E, Costantino S, et al. (2013). Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction. Circulation 127:1229-40, e1-21.
24. Raval Z, Losordo DW. (2013). Cell therapy of peripheral arterial disease: From experimental findings to clinical trials. Circ Res 112:1288-302.
25. Ruan C, Shen Y, Chen R, et al. (2013). Endothelial progenitor cells and atherosclerosis. Front Biosci (Landmark Ed) 18:1194-201.
26. Shawi M, Autexier C. (2008). Telomerase, senescence and ageing. Mech Ageing Dev 129:3-10.
27. Shi YA, Zhao Q, Zhang LH, et al. (2014). Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in vitro and in vivo. Int J Oncol 45:1216-24.
28. Shuai L, Li X, He Q, et al. (2012). Angiogenic effect of endothelial progenitor cells transfected with telomerase reverse transcriptase on peritubular microvessel in five out of six subtotal nephrectomy rats. Ren Fail 34:1270-80.
29. Takano H, Murasawa S, Asahara T. (2008). Functional and gene expression analysis of hTERT overexpressed endothelial cells. Biologics 2:547-54.
30. Thijssen DH, Torella D, Hopman MT, Ellison GM. (2009). The role of endothelial progenitor and cardiac stem cells in the cardiovascular adaptations to age and exercise. Front Biosci (Landmark Ed) 14:4685-702.
31. Thum T, Fraccarollo D, Thum S, et al. (2007). Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress. Arterioscler Thromb Vasc Biol 27:748-54.
32. Yang DG, Liu L, Zhou SH, et al. (2011). Remnant-like lipoproteins may accelerate endothelial progenitor cells senescence through inhibiting telomerase activity via the reactive oxygen species-dependent pathway. Can J Cardiol 27:628-34.
33. Zhou Z, Hu CP, Wang CJ, et al. (2010). Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression. Atherosclerosis 213:92-101.