Interleukin-1α activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1 receptor-2: Implications for allograft rejection

Journal of Biological Chemistry

Volumn 290, Issue 41, 2015, Pages 25188-25196

  Burzynski, Laura C ^a   Humphry, Melanie ^a   Bennett, Martin R ^a   Clarke, Murray C H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

CALPAINS; CASPASE-1; CYTOKINES; GRAFT REJECTION; INHIBITORY COMPLEX; INTERLEUKIN-1; MULTIPLE TARGETS;

ENDOTHELIAL CELLS;

CALPAIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA; IL1A PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DISSOCIATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GRAFT REJECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PROCESSING; ALLOGRAFT; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; NECROSIS; PATHOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL;

ALLOGRAFTS; CALPAIN; CASPASE 1; GRAFT REJECTION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1ALPHA; NECROSIS; PROTEOLYSIS; RECEPTORS, INTERLEUKIN-1 TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84943546474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.667915     Document Type: Article

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