Histologic Features of Intestinal Thrombotic Microangiopathy in Pediatric and Young Adult Patients after Hematopoietic Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 21, Issue 11, 2015, Pages 1994-2001

  El Bietar, Javier ^a   Warren, Mikako ^a   Dandoy, Christopher ^a   Myers, Kasiani C ^a   Lane, Adam ^a   Wallace, Gregory ^a   Davies, Stella M ^a   Jodele, Sonata ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Endothelial injury; Graft versus host disease TA TMA; Intestinal thrombotic microangiopathy; Thrombotic microangiopathy (TMA)

Indexed keywords

FIBRIN; MYELOABLATIVE AGENT;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BLOOD TRANSFUSION; CELL SEPARATION; CELL SWELLING; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; ENDOTHELIUM CELL; FEMALE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; GRAFT VERSUS HOST REACTION; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTESTINAL GRAFT VERSUS HOST DISEASE; INTESTINAL THROMBOTIC MICROANGIOPATHY; INTESTINE INJURY; INTESTINE MUCOSA; ISCHEMIC COLITIS; MALE; MICROTHROMBUS; MUCOSAL BLEEDING; THROMBOTIC THROMBOCYTOPENIC PURPURA; ALLOTRANSPLANTATION; APLASTIC ANEMIA; BONE MARROW DISEASE; COLITIS, ISCHEMIC; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBINURIA, PAROXYSMAL; IMMUNOLOGY; INFANT; INTESTINE; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MORTALITY; PATHOLOGY; PRESCHOOL CHILD; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL ANALYSIS; THROMBOTIC MICROANGIOPATHIES; TRANSPLANTATION CONDITIONING; VASCULARIZATION;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ANEMIA, APLASTIC; BONE MARROW DISEASES; CHILD; CHILD, PRESCHOOL; COLITIS, ISCHEMIC; FEMALE; GASTROINTESTINAL HEMORRHAGE; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; INFANT; INTESTINAL MUCOSA; INTESTINES; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MYELOABLATIVE AGONISTS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; THROMBOTIC MICROANGIOPATHIES; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 84943452345     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2015.06.016     Document Type: Article

References (31)

1. Hingorani S. Chronic kidney disease after pediatric hematopoietic cell transplant. Biol Blood Marrow Transplant 2008, 14:84-87.
2. Hingorani S. Chronic kidney disease in long-term survivors of hematopoietic cell transplantation: epidemiology, pathogenesis, and treatment. J Am Soc Nephrol 2006, 17:1995-2005.
3. Hingorani S., Guthrie K.A., Schoch G., et al. Chronic kidney disease in long-term survivors of hematopoietic cell transplant. Bone Marrow Transplant 2007, 39:223-229.
4. Oeffinger K.C., Mertens A.C., Sklar C.A., et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006, 355:1572-1582.
5. Oeffinger K.C., Hudson M.M., Landier W. Survivorship: childhood cancer survivors. Prim Care 2009, 36:743-780.
6. Jodele S., Laskin B.L., Dandoy C.E., et al. A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev 2015, 29:191-204.
7. Jodele S., Davies S.M., Lane A., et al. Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Blood 2014, 124:645-653.
8. Inamoto Y., Ito M., Suzuki R., et al. Clinicopathological manifestations and treatment of intestinal transplant-associated microangiopathy. Bone Marrow Transplant 2009, 44:43-49.
9. Narimatsu H., Kami M., Hara S., et al. Intestinal thrombotic microangiopathy following reduced-intensity umbilical cord blood transplantation. Bone Marrow Transplant 2005, 36:517-523.
10. Nishida T., Hamaguchi M., Hirabayashi N., et al. Intestinal thrombotic microangiopathy after allogeneic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease. Bone Marrow Transplant 2004, 33:1143-1150.
11. Ho V.T., Cutler C., Carter S., et al. Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005, 11:571-575.
12. Cho B.S., Min C.K., Eom K.S., et al. Clinical impact of thrombotic microangiopathy on the outcome of patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2008, 41:813-820.
13. Cho B.S., Yahng S.A., Lee S.E., et al. Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoietic stem-cell transplantation. Transplantation 2010, 90:918-926.
14. Ruutu T., Barosi G., Benjamin R.J., et al. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica 2007, 92:95-100.
15. Glucksberg H., Storb R., Fefer A., et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974, 18:295-304.
16. Laskin B.L., Goebel J., Davies S.M., Jodele S. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood 2011, 118:1452-1462.
17. Yamada-Fujiwara M., Miyamura K., Fujiwara T., et al. Diagnosis of intestinal graft-versus-host disease and thrombotic microangiopathy after allogeneic stem cell transplantation. Tohoku J Exp Med 2012, 227:31-37.
18. Komeno Y., Ogawa S., Ishida T., et al. Ischemic colitis as a manifestation of thrombotic microangiopathy following bone marrow transplantation. Intern Med 2003, 42:1228-1232.
19. Jodele S., Fukuda T., Vinks A., et al. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biol Blood Marrow Transplant 2014, 20:518-525.
20. Laskin B.L., Goebel J., Davies S.M., et al. Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT. Bone Marrow Transplant 2011, 46:682-689.
21. Dietrich S., Falk C.S., Benner A., et al. Endothelial vulnerability and endothelial damage are associated with risk of graft-versus-host disease and response to steroid treatment. Biol Blood Marrow Transplant 2013, 19:22-27.
22. Luft T., Dietrich S., Falk C., et al. Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system. Blood 2011, 118:1685-1692.
23. Jodele S., Hirsch R., Laskin B., et al. Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant 2013, 19:202-207.
24. Dandoy C.E., Davies S.M., Hirsch R., et al. Abnormal echocardiography 7 days after stem cell transplantation may be an early indicator of thrombotic microangiopathy. Biol Blood Marrow Transplant 2015, 21:113-118.
25. Holler E., Kolb H.J., Hiller E., et al. Microangiopathy in patients on cyclosporine prophylaxis who developed acute graft-versus-host disease after HLA-identical bone marrow transplantation. Blood 1989, 73:2018-2024.
26. Tezcan H., Zimmer W., Fenstermaker R., et al. Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506. Bone Marrow Transplant 1998, 21:105-109.
27. Paquette R.L., Tran L., Landaw E.M. Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft-versus-host disease prophylaxis. Bone Marrow Transplant 1998, 22:351-357.
28. Fujino M., Kim Y., Ito M. Intestinal thrombotic microangiopathy induced by FK506 in rats. Bone Marrow Transplant 2007, 39:367-372.
29. Piscitelli D., Fiore M.G., Rossi R., et al. Unusual case report of thrombotic microangiopathy of the small bowel following liver transplantation, a possible immunosuppressant-induced disease with histological and ultrastructural findings. ScientificWorldJournal 2009, 9:1031-1034.
30. Dierickx D., Monbaliu D., De Rycke A., et al. Thrombotic microangiopathy following intestinal transplantation: a single center experience. Transplant Proc 2010, 42:79-81.
31. Worel N., Greinix H.T., Leitner G., et al. ABO-incompatible allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning: close association with transplant-associated microangiopathy. Transfus Apher Sci 2007, 36:297-304.