Effect of the Kv1.3 voltage-gated potassium channel blocker PAP-1 on the initiation and progress of atherosclerosis in a rat model

Heart and Vessels

Volumn 30, Issue 1, 2015, Pages 108-114

  Wu, Xiaofen ^a   Xu, Rende ^a   Cao, Ming ^a   Ruan, Lei ^a   Wang, Xingfen ^a   Zhang, Cuntai ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Atherosclerosis plaque; Kv1.3 potassium channel; T lymphocyte

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; LIPID; PERFORIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3;

ACUTE CORONARY SYNDROME; ANIMAL; ANTAGONISTS AND INHIBITORS; ATHEROSCLEROSIS; BLOOD; COMMON CAROTID ARTERY; COMPLICATION; DISEASE MODEL; IMMUNOLOGY; MALE; PATHOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PLAQUE, ATHEROSCLEROTIC; RAT; T LYMPHOCYTE; THORACIC AORTA; WISTAR RAT;

ACUTE CORONARY SYNDROME; ANGIOPLASTY, BALLOON; ANIMALS; AORTA, THORACIC; ATHEROSCLEROSIS; C-REACTIVE PROTEIN; CAROTID ARTERY, COMMON; DISEASE MODELS, ANIMAL; INTERFERON-GAMMA; KV1.3 POTASSIUM CHANNEL; LIPIDS; MALE; PERFORIN; PLAQUE, ATHEROSCLEROTIC; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR; T-LYMPHOCYTES;

EID: 84943422269     PISSN: 09108327     EISSN: 16152573     Source Type: Journal    
DOI: 10.1007/s00380-013-0462-7     Document Type: Article

References (23)

1. Libby P (2002) Inflammation in atherosclerosis. Nature 420(6917):868–874
2. Wen J, Wen Y, Zhiliang L, Lingling C, Longxing C, Ming W, Qiang F (2013) A decrease in the percentage of circulating mDC precursors in patients with coronary heart disease: a relation to the severity and extent of coronary artery lesions? Heart Vessel 28:135–142
3. Tani S, Matsumoto M, Anazawa T, Kawamata H, Furuya S, Takahashi H, Iida K, Washio T, Kumabe N, Kobori M, Nagao K, Hirayama A (2012) Development of a model for prediction of coronary atherosclerotic regression: evaluation of high-density lipoprotein cholesterol level and peripheral blood monocyte count. Heart Vessel 27:143–150
4. null T cells in patients with acute coronary syndrome. Circ Res 110:857–869
5. null T cells in coronary artery disease: when helpers become killers. Cardiovasc Res 81:11–19
6. null T cells in patients with coronary artery disease and individuals with risk factors for atherosclerosis. Cell Immunol 281:11–19
7. Damjanovich S, Gaspar R, Panyi G (2004) An alternative to conventional immunosuppression: small molecule inhibitors of kv1.3 channels. Mol Interv 4(5):250–254
8. Beeton C, Chandy KG (2005) Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist 11(6):550–562
9. null cells in patients with acute coronary syndrome. Clin Immunol 142:209–217
10. Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hänsel W, Wulff H (2005) Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol 68:1254–1270
11. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, Lee Healey CJ, Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG (2006) Kv1.3 channels are a therapeutic target for T-cell mediated autoimmune diseases. Proc Natl Acad Sci USA 103:17414–17419
12. Azam P, Sankaranarayanan A, Homerick D, Griffey S, Wulff H (2007) Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol 127:1419–1429
13. Fonseca FA, Paiva TB, Silva EG, Ihara SS, Kasinski N, Martinez TL, Filho EE (1998) Dietary magnesium improves endothelial dependent relaxation of balloon injured arteries in rats. Atherosclerosis 139(2):237–242
14. Cao RY, St Amand T, Grabner R, Habenicht AJ, Funk CD (2009) Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Atherosclerosis 203(2):395–400
15. Tsukamoto K, Tangirala R, Chun SH, Puré E, Rader DJ (1999) Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(9):2162–2170
16. Su Z, Li Y, James JC, McDuffie M, Matsumoto AH, Helm GA, Weber JL, Lusis AJ, Shi W (2006) Quantitative trait locus analysis of atherosclerosis in an intercross between c57bl/6 and c3h mice carrying the mutant apolipoprotein e gene. Genetics 172(3):1799–1807
17. Hansson CK, Libby P (2006) The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6:508–519
18. Paulsson G, Zhou X, Tornquist E, Hansson GK (2000) Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(1):10–17
19. Ishida Y, Chused TM (1993) Lack of voltage sensitive potassium channels and generation of membrane potential by sodium potassium ATPase in murine T lymphocytes. J Immunol 151(2):610–620
20. Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P, Wunderler DL, McManus OB, Slaughter R, Bugianesi R, Felix J, Garcia M, Williamson J, Kaczorowski G, Sigal NH, Springer MS, Feeney W (1997) Blockade of the voltage-gated potassium channel kv1.3 inhibits immune responses in vivo. J Immunol 158(11):5120–5128
21. Yang PY, Rui YC, Lu L, Li TJ, Liu SQ, Yan HX, Wang HY (2005) Time courses of vascular endothelial growth factor and intercellular adhesion molecule-1 expressions in aortas of atherosclerotic rats. Life Sci 77(20):2529–2539
22. Wu X, Huang H, Tang F, Le K, Xu S, Liu P (2010) Regulated expression of endothelial lipase in atherosclerosis. Mol Cell Endocrinol 315(1–2):233–238
23. Yanni AE (2004) The laboratory rabbit: an animal model of atherosclerosis research. Lab Anim 38(3):246–256