pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth

Oncotarget

Volumn 6, Issue 27, 2015, Pages 23523-23532

  Li, Suping ^a   Tian, Yanhua ^b   Zhao, Ying ^a   Zhang, Yinlong ^a   Su, Shishuai ^a   Wang, Jing ^a   Wu, Meiyu ^a   Shi, Quanwei ^a   Anderson, Gregory J ^c   Thomsen, Johannes ^d   Zhao, Ruifang ^a   Ji, Tianjiao ^a   Wang, Jie ^e   Nie, Guangjun ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b PEKING UNIVERSITY   (China)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

pH low insertion peptide (pHLIP); Thrombosis; Truncated tissue factor (tTF); Tumor vessel targeting

Indexed keywords

PEPTIDE; PH LOW INSERTION PEPTIDE; THROMBOPLASTIN; TRUNCATED TISSUE FACTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BLOOD CLOTTING FACTOR 10; LIPID BILAYER; MEMBRANE PROTEIN; PHLIP PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD CLOTTING; CANCER INHIBITION; CELL SURFACE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG TOLERABILITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOUSE; NEOPLASM; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TUMOR THROMBUS; ANIMAL; BAGG ALBINO MOUSE; BREAST TUMOR; CANCER TRANSPLANTATION; CELL MEMBRANE; CHEMISTRY; EXPERIMENTAL MELANOMA; FEMALE; GENE EXPRESSION REGULATION; LIPID BILAYER; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; NUDE MOUSE; PATHOLOGY; PERFUSION; PROTEIN TERTIARY STRUCTURE; THROMBOSIS; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD COAGULATION; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; FACTOR X; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPID BILAYERS; MELANOMA, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PERFUSION; PROTEIN STRUCTURE, TERTIARY; THROMBOPLASTIN; THROMBOSIS;

EID: 84943387765     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4395     Document Type: Article

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