Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries

Basic and Clinical Pharmacology and Toxicology

Volumn 117, Issue 5, 2015, Pages 297-305

  Skovsted, Gry Freja ^a,c   Kilic, Semsi ^a   Edvinsson, Lars ^a,b  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ENDOTHELIN 1; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; MESSENGER RNA; VASOCONSTRICTOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY CONSTRICTION; DESENSITIZATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; INTERNALIZATION; MALE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; AGONISTS; ANIMAL; COMPARATIVE STUDY; CORONARY BLOOD VESSEL; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEART INFARCTION; HUMAN; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; REPERFUSION INJURY; SPRAGUE DAWLEY RAT; TIME FACTOR; VASOCONSTRICTION;

ANIMALS; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELIN-3; GENE EXPRESSION REGULATION; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; ORGAN CULTURE TECHNIQUES; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RNA, MESSENGER; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 84943361229     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12407     Document Type: Article

References (44)

1. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K et al. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci USA 1989;86:2863-7.
2. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5.
3. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990;348:730-2.
4. Panek RL, Major TC, Hingorani GP, Doherty AM, Taylor DG, Rapundalo ST. Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem Biophys Res Commun 1992;183:566-71.
5. Compeer MG, Suylen DP, Hackeng TM, De Mey JG. Endothelin-1 and -2: two amino acids matter. Life Sci 2012;91:607-12.
6. Compeer MG, Janssen GM, De Mey JG. Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries. Br J Pharmacol 2013;170:1199-209.
7. Plumpton C, Ashby MJ, Kuc RE, O'Reilly G, Davenport AP. Expression of endothelin peptides and mRNA in the human heart. Clin Sci (Lond) 1996;90:37-46.
8. Saetrum Opgaard O, Adner M, Peters TH, Xu CB, Stavenow L, Gulbenkian S et al. Endocardial expression and functional characterization of endothelin-1. Mol Cell Biochem 2001;224:151-8.
9. Uchide T, Adur J, Fukamachi T, Saida K. Quantitative analysis of endothelin-1 and vasoactive intestinal contractor/endothelin-2 gene expression in rats by real-time reverse transcriptase polymerase chain reaction. J Cardiovasc Pharmacol 2000;36:S5-8.
10. Matsumoto H, Suzuki N, Kitada C, Fujino M. Endothelin family peptides in human plasma and urine: their molecular forms and concentrations. Peptides 1994;15:505-10.
11. Takahashi K, Ghatei MA, Jones PM, Murphy JK, Lam HC, O'Halloran DJ et al. Endothelin in human brain and pituitary gland: presence of immunoreactive endothelin, endothelin messenger ribonucleic acid, and endothelin receptors. J Clin Endocrinol Metab 1991;72:693-9.
12. Yu JC, Davenport AP. Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells. Br J Pharmacol 1995;114:551-7.
13. Davenport AP, Kuc RE, Mockridge JW. Endothelin-converting enzyme in the human vasculature: evidence for differential conversion of big endothelin-3 by endothelial and smooth-muscle cells. J Cardiovasc Pharmacol 1998;31(Suppl 1):S1-3.
14. Adner M, Uddman E, Cardell LO, Edvinsson L. Regional variation in appearance of vascular contractile endothelin-B receptors following organ culture. Cardiovasc Res 1998;37:254-62.
15. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol 1999;61:391-415.
16. Filep JG, Battistini B, Cote YP, Beaudoin AR, Sirois P. Endothelin-1 induces prostacyclin release from bovine aortic endothelial cells. Biochem Biophys Res Commun 1991;177:171-6.
17. Hirata Y, Emori T, Eguchi S, Kanno K, Imai T, Ohta K et al. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J Clin Invest 1993;91:1367-73.
18. Tonnessen T, Christensen G, Oie E, Holt E, Kjekshus H, Smiseth OA et al. Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats. Cardiovasc Res 1997;33:601-10.
19. Li JJ, Wu LH, Cao Q, Yuan Y, Yang L, Guo ZY et al. Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult rats. Neuroscience 2010;167:665-77.
20. Wang X, Douglas SA, Feuerstein GZ, Ohlstein EH. Temporal expression of ECE-1, ET-1, ET-3, ETA, and ETB receptor mRNAs after balloon angioplasty in the rat. J Cardiovasc Pharmacol 1995;26(Suppl 3):S22-5.
21. Pernow J, Bohm F, Johansson BL, Hedin U, Ryden L. Enhanced vasoconstrictor response to endothelin-B-receptor stimulation in patients with atherosclerosis. J Cardiovasc Pharmacol 2000;36:S418-20.
22. Stenman E, Malmsjo M, Uddman E, Gido G, Wieloch T, Edvinsson L. Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat. Stroke 2002;33:2311-6.
23. Vikman P, Edvinsson L. Gene expression profiling in the human middle cerebral artery after cerebral ischemia. Eur J Neurol 2006;13:1324-32.
24. Dagassan PH, Breu V, Clozel M, Kunzli A, Vogt P, Turina M et al. Up-regulation of endothelin-B receptors in atherosclerotic human coronary arteries. J Cardiovasc Pharmacol 1996;27:147-53.
25. Skovsted GF, Kruse LS, Larsen R, Pedersen AF, Trautner S, Sheykhzade M et al. Heart ischaemia-reperfusion induces local up-regulation of vasoconstrictor endothelin ETB receptors in rat coronary arteries downstream of occlusion. Br J Pharmacol 2014;171:2726-38.
26. Wackenfors A, Emilson M, Ingemansson R, Hortobagyi T, Szok D, Tajti J et al. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Eur J Pharmacol 2004;484:103-9.
27. Bauer M, Wilkens H, Langer F, Schneider SO, Lausberg H, Schafers HJ. Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension. Circulation 2002;105:1034-6.
28. Eskesen K, Edvinsson L. Upregulation of endothelin ETB receptor-mediated vasoconstriction in rat coronary artery after organ culture. Eur J Pharmacol 2006;539:192-4.
29. Johnsson E, Maddahi A, Wackenfors A, Edvinsson L. Enhanced expression of contractile endothelin ET(B) receptors in rat coronary artery after organ culture. Eur J Pharmacol 2008;582:94-101.
30. Skovsted GF, Pedersen AF, Larsen R, Sheykhzade M, Edvinsson L. Rapid functional upregulation of vasocontractile endothelin ETB receptors in rat coronary arteries. Life Sci 2012;91:593-9.
31. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS One 2010;1:94-9.
32. Wendel M, Kummer W, Knels L, Schmeck J, Koch T. Muscular ETB receptors develop postnatally and are differentially distributed in specific segments of the rat vasculature. J Histochem Cytochem 2005;53:187-96.
33. Evans NJ, Walker JW. Endothelin receptor dimers evaluated by FRET, ligand binding, and calcium mobilization. Biophys J 2008;95:483-92.
34. Gregan B, Jurgensen J, Papsdorf G, Furkert J, Schaefer M, Beyermann M et al. Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J Biol Chem 2004;279:27679-87.
35. Gregan B, Schaefer M, Rosenthal W, Oksche A. Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers. J Cardiovasc Pharmacol 2004;44(Suppl 1):S30-3.
36. Rapoport RM, Zuccarello M. Endothelin(A)-endothelin(B) receptor cross talk in endothelin-1-induced contraction of smooth muscle. J Cardiovasc Pharmacol 2012;60:483-94.
37. Lefkowitz RJ. G protein-coupled receptor kinases. Cell 1993;74:409-12.
38. Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ. Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. J Biol Chem 1997;272:17734-43.
39. Abe Y, Nakayama K, Yamanaka A, Sakurai T, Goto K. Subtype-specific trafficking of endothelin receptors. J Biol Chem 2000;275:8664-71.
40. Dai X, Galligan JJ. Differential trafficking and desensitization of human ET(A) and ET(B) receptors expressed in HEK 293 cells. Exp Biol Med (Maywood) 2006;231:746-51.
41. Bremnes T, Paasche JD, Mehlum A, Sandberg C, Bremnes B, Attramadal H. Regulation and intracellular trafficking pathways of the endothelin receptors. J Biol Chem 2000;275:17596-604.
42. Okamoto Y, Ninomiya H, Miwa S, Masaki T. Cholesterol oxidation switches the internalization pathway of endothelin receptor type A from caveolae to clathrin-coated pits in Chinese hamster ovary cells. J Biol Chem 2000;275:6439-46.
43. Panek RL, Major TC, Hingorani GP, Doherty AM, Taylor DG, Rapundalo ST. Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem Biophys Res Commun 1992;183:566-71.
44. Schulte G, Levy FO. Novel aspects of G-protein-coupled receptor signalling-different ways to achieve specificity. Acta physiologica 2007;190:33-8.