Is hemoglobin level in patients with nasopharyngeal carcinoma still a significant prognostic factor in the era of intensity-modulated radiotherapy technology?

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Guo, Shan Shan ^a   Tang, Lin Quan ^a   Chen, Qiu Yan ^a   Zhang, Lu ^a   Liu, Li Ting ^a   Huang, Pei Yu ^a   Cao, Ka Jia ^a   Guo, Ling ^a   Mo, Hao Yuan ^a   Guo, Xiang ^a   Hong, Ming Huang ^a   Zeng, Mu Sheng ^a   Qian, Chao Nan ^a   Mai, Hai Qiang ^a   Santini, Daniele ^b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; HEMOGLOBIN;

ADOLESCENT; ADULT; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISTANT METASTASIS; DISTANT METASTASIS FREE SURVIVAL; FEMALE; FOLLOW UP; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LOCAL RECURRENCE FREE SURVIVAL; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; RETROSPECTIVE STUDY; SEX RATIO; SURVIVAL RATE; ADVERSE EFFECTS; BLOOD; MIDDLE AGED; MORTALITY; NASOPHARYNGEAL NEOPLASMS; PROGNOSIS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANEMIA; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; PROGNOSIS; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES; SURVIVAL RATE; YOUNG ADULT;

EID: 84943303374     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136033     Document Type: Article

References (28)

1. Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2006; 15(10): 1765-77. Epub 2006/10/13. doi: 10.1158/1055-9965.epi-06-0353 PMID: 17035381.
2. Xu ZJ, Zheng RS, Zhang SW, Zou XN, Chen WQ. Nasopharyngeal carcinoma incidence and mortality in China in 2009. Chinese journal of cancer. 2013; 32(8): 453-60. Epub 2013/07/19. doi: 10.5732/cjc.013.10118 PMID: 23863562; PubMed Central PMCID: PMCPMC3845582.
3. Young LS, Dawson CW, Clark D, Rupani H, Busson P, Tursz T, et al. Epstein-Barr virus gene expression in nasopharyngeal carcinoma. The Journal of general virology. 1988; 69 (Pt 5): 1051-65. Epub 1988/05/01. PMID: 2836550.
4. zur Hausen H, Schulte-Holthausen H, Klein G, Henle W, Henle G, Clifford P, et al. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature. 1970; 228(5276): 1056-8. Epub 1970/12/12. PMID: 4320657.
5. Leung SF, Chan KC, Ma BB, Hui EP, Mo F, Chow KC, et al. Plasma Epstein-Barr viral DNA load at midpoint of radiotherapy course predicts outcome in advanced-stage nasopharyngeal carcinoma. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO. 2014; 25(6): 1204-8. Epub 2014/03/19. doi: 10.1093/annonc/mdu117 PMID: 24638904.
6. Pattle SB, Farrell PJ. The role of Epstein-Barr virus in cancer. Expert opinion on biological therapy. 2006; 6(11): 1193-205. Epub 2006/10/20. doi: 10.1517/14712598.6.11.1193 PMID: 17049016.
7. Gu MF, Liu LZ, He LJ, Yuan WX, Zhang R, Luo GY, et al. Sequential chemoradiotherapy with gemcitabine and cisplatin for locoregionally advanced nasopharyngeal carcinoma. International journal of cancer Journal international du cancer. 2013; 132(1): 215-23. Epub 2012/05/23. doi: 10.1002/ijc.27638 PMID: 22610788.
8. Zenda S, Hironaka S, Boku N, Yamazaki K, Yasui H, Fukutomi A, et al. Impact of hemoglobin level on survival in definitive chemoradiotherapy for T4/M1 lymph node esophageal cancer. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus/ISDE. 2008; 21 (3): 195-200. Epub 2008/04/24. doi: 10.1111/j.1442-2050.2007.00750.x PMID: 18430098.
9. Grogan M, Thomas GM, Melamed I, Wong FL, Pearcey RG, Joseph PK, et al. The importance of hemoglobin levels during radiotherapy for carcinoma of the cervix. Cancer. 1999; 86(8): 1528-36. Epub 1999/10/20. PMID: 10526282.
10. Munstedt K, Volzing M, Von Georgi R. Hemoglobin levels during radiation therapy and their influence on local control and survival of patients with endometrial carcinoma. Oncology reports. 2004; 11 (3): 711-7. Epub 2004/02/10. PMID: 14767527.
11. Gao J, Hu JY, Xia YF, Yi W, Tao YL, Li G. Continuous fall in hemoglobin level is a poor prognostic factor in patients with nasopharyngeal carcinoma treated with radiotherapy. Chinese journal of cancer. 2010; 29(5): 561-6. Epub 2010/04/30. PMID: 20426909.
12. Gao J, Tao YL, Li G, Yi W, Xia YF. Involvement of difference in decrease of hemoglobin level in poor prognosis of Stage I and II nasopharyngeal carcinoma: implication in outcome of radiotherapy. International journal of radiation oncology, biology, physics. 2012; 82(4): 1471-8. Epub 2011/06/29. doi: 10.1016/j.ijrobp.2011.05.009 PMID: 21708429.
13. Chua DT, Sham JS, Choy DT. Prognostic impact of hemoglobin levels on treatment outcome in patients with nasopharyngeal carcinoma treated with sequential chemoradiotherapy or radiotherapy alone. Cancer. 2004; 101(2): 307-16. Epub 2004/07/09. doi: 10.1002/cncr.20366 PMID: 15241828.
14. Kong FF, Ying H, Du CR, Huang S, Zhou JJ, Hu CS. Effectiveness and toxicities of intensity-modulated radiation therapy for patients with T4 nasopharyngeal carcinoma. PloS one. 2014; 9(3): e91362. Epub 2014/03/13. doi: 10.1371/journal.pone.0091362 PMID: 24608637; PubMed Central PMCID: PMCPmc3946722.
15. Kong F, Ying H, Huang S, Du C, Zhou J, Hu C. Preliminary results of nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: a retrospective study of 364 patients. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2014; 271(12): 3283-90. Epub 2014/02/19. doi: 10.1007/s00405-014-2900-2 PMID: 24534894.
16. Moretto F, Rampino M, Munoz F, Ruo Redda MG, Reali A, Balcet V, et al. Conventional 2D (2DRT) and 3D conformal radiotherapy (3DCRT) versus intensity-modulated radiotherapy (IMRT) for nasopharyngeal cancer treatment. La Radiologia medica. 2014; 119(8): 634-41. Epub 2014/01/16. doi: 10.1007/s11547-013-0359-7 PMID: 24424659.
17. Zhao C, Han F, Lu LX, Huang SM, Lin CG, Deng XW, et al. [Intensity modulated radiotherapy for local-regional advanced nasopharyngeal carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. 2004; 23(11 Suppl): 1532-7. Epub 2004/11/30. PMID: 15566674.
18. Rades D, Lang S, Schild SE, Alberti W. Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer. Clinical oncology (Royal College of Radiologists (Great Britain)). 2006; 18(2): 139-44. Epub 2006/03/10. PMID: 16523815.
19. Becker A, Stadler P, Lavey RS, Hansgen G, Kuhnt T, Lautenschlager C, et al. Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas. International journal of radiation oncology, biology, physics. 2000; 46(2): 459-66. Epub 2000/02/08. PMID: 10661354.
20. Mujcic H, Hill RP, Koritzinsky M, Wouters BG. Hypoxia signaling and the metastatic phenotype. Current molecular medicine. 2014; 14(5): 565-79. Epub 2014/06/05. PMID: 24894165.
21. Walter CJ, Bell LT, Parsons SR, Jackson C, Borley NR, Wheeler JM. Prevalence and significance of anaemia in patients receiving long-course neoadjuvant chemoradiotherapy for rectal carcinoma. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland. 2013; 15(1): 52-6. Epub 2012/05/31. doi: 10.1111/j.1463-1318.2012.03112.x PMID: 22642876.
22. Yoshino I. [Treatment of cancer chemotherapy-associated anemia in Japan - conditions and issues]. Ganto kagaku ryoho Cancer & chemotherapy. 2014; 41(4): 426-31. Epub 2014/04/20. PMID: 24743358.
23. Kadokura G, Katsumata N. [Treatment of chemotherapy-induced anemia]. Gan to kagaku ryoho Cancer & chemotherapy. 2014; 41(4): 416-20. Epub 2014/04/20. PMID: 24743356.
24. Cordella C, Luebbers HT, Rivelli V, Gratz KW, Kruse AL. An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma. Head & neck oncology. 2011; 3: 35. Epub 2011/08/17. doi: 10.1186/1758-3284-3-35 PMID: 21843350; PubMed Central PMCID: PMCPmc3199902.
25. Vaupel P, Mayer A. Hypoxia and anemia: effects on tumor biology and treatment resistance. Transfusion clinique et biologique: journal de la Societe francaise de transfusion sanguine. 2005; 12(1): 5-10. Epub 2005/04/09. doi: 10.1016/j.tracli.2004.11.005 PMID: 15814285.
26. Hong B, Lui VW, Hashiguchi M, Hui EP, Chan AT. Targeting tumor hypoxia in nasopharyngeal carcinoma. Head & neck. 2013; 35(1): 133-45. Epub 2011/11/23. doi: 10.1002/hed.21877 PMID: 22106024.
27. Henke M, Bechtold C, Momm F, Dorr W, Guttenberger R. Blood hemoglobin level may affect radiosen-sitivity-preliminary results on acutely reacting normal tissues. International journal of radiation oncology, biology, physics. 2000; 48(2): 339-45. Epub 2000/09/07. PMID: 10974446.
28. Vaupel P, Thews O, Hoeckel M. Treatment resistance of solid tumors: role of hypoxia and anemia. Medical oncology (Northwood, London, England). 2001; 18(4): 243-59. Epub 2002/03/29. doi: 10.1385/mo:18:4:243 PMID: 11918451.