Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque

Journal of Atherosclerosis and Thrombosis

Volumn 22, Issue 10, 2015, Pages 1051-1060

  Toshikuni, Nobuyuki ^a   Asaji, Takayoshi ^a   Nakanishi, Yumiko ^a   Nagasawa, Shin Ya ^a   Uenishi, Hiroaki ^a   Tsutsumi, Mikihiro ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Carotid plaque; Fatty liver; Gamma glutamyl transpeptidase

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; DYSLIPIDEMIA; FATTY LIVER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; AGED; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD; CAROTID ARTERY DISEASE; COMPLICATION; ECHOGRAPHY; ENZYMOLOGY; FOLLOW UP; MIDDLE AGED; ODDS RATIO; PREDICTIVE VALUE; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR;

ADULT; AGED; ATHEROSCLEROSIS; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; FATTY LIVER; FEMALE; FOLLOW-UP STUDIES; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PLAQUE, ATHEROSCLEROTIC; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84943247164     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.28274     Document Type: Article

References (35)

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics C and Stroke Statistics S: Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation, 2013; 127: e6-e245
2. Mahmood SS, Levy D, Vasan RS, Wang TJ: The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. Lancet, 2014; 383: 999-1008
3. Barth JD: An update on carotid ultrasound measurement of intima-media thickness. Am J Cardiol, 2002; 89: 32B-38B; discussion 38B-39B
4. Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino RB Sr: Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med, 2011; 365: 213-221
5. Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Volzke H, Tuomainen TP, Sander D, Plichart M, Catapano AL, Robertson CM, Kiechl S, Rundek T, Desvarieux M, Lind L, Schmid C, DasMahapatra P, Gao L, Ziegelbauer K, Bots ML, Thompson SG, Group P-IS: Carotid intimamedia thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data. Lancet, 2012; 379: 2053-2062
6. van den Oord SC, Sijbrands EJ, ten Kate GL, van Klaveren D, van Domburg RT, van der Steen AF, Schinkel AF: Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis, 2013; 228: 1-11
7. Chambless LE, Folsom AR, Davis V, Sharrett R, Heiss G, Sorlie P, Szklo M, Howard G, Evans GW: Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998. Am J Epidemiol, 2002; 155: 38-47
8. Vernon G, Baranova A, Younossi ZM: Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther, 2011; 34: 274-285
9. Sookoian S, Pirola CJ: Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review. J Hepatol, 2008; 49: 600-607
10. Carallo C, Mancuso G, Mauro G, Laghi F, Madafferi B, Irace C, Gnasso A, Scavelli F, Dell’Aquila F, Bartone M, Gullo F, Ferraro M, Spagnuolo V, Belmonte M, Ferrara A, Silvano Rotondaro A, Brandolino N, Parasporo F, Scopelliti F: Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO Study. J Gastroenterol, 2009; 44: 1156-1161
11. Kozakova M, Palombo C, Eng MP, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E, Investigators R: Fatty liver index, gamma-glutamyltransferase, and early carotid plaques. Hepatology, 2012; 55: 1406-1415
12. Nakagawa H, Isogawa A, Tateishi R, Tani M, Yoshida H, Yamakado M, Koike K: Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population. J Gastroenterol, 2011;
13. Turgut O, Tandogan I: Gamma-glutamyltransferase to determine cardiovascular risk: shifting the paradigm forward. J Atheroscler Thromb, 2011; 18: 177-181
14. Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA: Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women’s Heart and Health Study and Meta-Analysis. Arterioscler Thromb Vasc Biol, 2007; 27: 2729-2735
15. Du G, Song Z, Zhang Q: Gamma-glutamyltransferase is associated with cardiovascular and all-cause mortality: a meta-analysis of prospective cohort studies. Prev Med, 2013; 57: 31-37
16. Targher G, Marra F, Marchesini G: Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon ? Diabetologia, 2008; 51: 1947-1953
17. Haring R, Wallaschofski H, Nauck M, Dorr M, Baumeister SE, Volzke H: Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Hepatology, 2009; 50: 1403-1411
18. Ogihara T, Kikuchi K, Matsuoka H, Fujita T, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ito S, Iwao H, Kario K, Kawano Y, Kim-Mitsuyama S, Kimura G, Matsubara H, Matsuura H, Naruse M, Saito I, Shimada K, Shimamoto K, Suzuki H, Takishita S, Tanahashi N, Tsuchihashi T, Uchiyama M, Ueda S, Ueshima H, Umemura S, Ishimitsu T, Rakugi H and Japanese Society of Hypertension C: The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res, 2009; 32: 3-107
19. Teramoto T, Sasaki J, Ueshima H, Egusa G, Kinoshita M, Shimamoto K, Daida H, Biro S, Hirobe K, Funahashi T, Yokote K, Yokode M: Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb, 2007; 14: 155-158
20. Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes M, Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E, Ito C, Inagaki N, Iwamoto Y, Kasuga M, Hanafusa T, Haneda M, Ueki K: Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig, 2010; 1: 212-228
21. Teramoto T, Sasaki J, Ueshima H, Egusa G, Kinoshita M, Shimamoto K, Daida H, Biro S, Hirobe K, Funahashi T, Yokote K, Yokode M: Metabolic syndrome. J Atheroscler Thromb, 2008; 15: 1-5
22. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Jaff M, Kownator S, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M: Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis, 2007; 23: 75-80
23. Lee SS, Park SH: Radiologic evaluation of nonalcoholic fatty liver disease. World J Gastroenterol, 2014; 20: 7392-7402
24. Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C: The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol, 2006; 6: 33
25. Chitturi S, Farrell GC, Hashimoto E, Saibara T, Lau GK, Sollano JD and Asia-Pacific Working Party on N: Nonalcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines. J Gastroenterol Hepatol, 2007; 22: 778-787
26. Breitling LP, Raum E, Muller H, Rothenbacher D, Brenner H: Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase. Hepatology, 2009; 49: 802-808
27. Tynjala J, Kangastupa P, Laatikainen T, Aalto M, Niemela O: Effect of age and gender on the relationship between alcohol consumption and serum GGT: time to recalibrate goals for normal ranges. Alcohol Alcohol, 2012; 47: 558-562
28. Alatalo PI, Koivisto HM, Hietala JP, Puukka KS, Bloigu R, Niemela OJ: Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index. Am J Clin Nutr, 2008; 88: 1097-1103
29. Paolicchi A, Emdin M, Ghliozeni E, Ciancia E, Passino C, Popoff G, Pompella A: Images in cardiovascular medicine. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity. Circulation, 2004; 109: 1440
30. Emdin M, Pompella A, Paolicchi A: Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque. Circulation, 2005; 112: 2078-2080
31. Franzini M, Corti A, Martinelli B, Del Corso A, Emdin M, Parenti GF, Glauber M, Pompella A, Paolicchi A: Gamma-glutamyltransferase activity in human atherosclerotic plaques--biochemical similarities with the circulating enzyme. Atherosclerosis, 2009; 202: 119-127
32. Targher G, Day CP, Bonora E: Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med, 2010; 363: 1341-1350
33. Targher G, Bertolini L, Rodella S, Lippi G, Franchini M, Zoppini G, Muggeo M, Day CP: NASH predicts plasma inflammatory biomarkers independently of visceral fat in men. Obesity (Silver Spring), 2008; 16: 1394-1399
34. Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, Zenari L, Cigolini M, Falezza G, Arcaro G: Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease. Diabetes Care, 2006; 29: 1325-1330
35. Leite NC, Villela-Nogueira CA, Pannain VL, Bottino AC, Rezende GF, Cardoso CR, Salles GF: Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors. Liver Int, 2011; 31: 700-706