Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: The STEATO Study

Journal of Gastroenterology

Volumn 44, Issue 11, 2009, Pages 1156-1161

  Carallo, Claudio ^a   Mancuso, Gerardo ^b   Mauro, Gaetano ^c   Laghi, Ferdinando ^c   Madafferi, Bruno ^d   Irace, Concetta ^a   Gnasso, Agostino ^a   Scavelli, Faustina ^a   Dell'Aquila, Ferruccio ^a   Bartone, Mosè ^b   Gullo, Francesco ^b   Ferraro, Maria ^c   Spagnuolo, Vitaliano ^c   Belmonte, Maria ^c   Ferrara, Antonio ^c   Rotondaro, Antonio Silvano ^c   Brandolino, Nicola ^d   Parasporo, Francesca ^d   Scopelliti, Francesco ^d  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b General Hospital   (Italy)

^c General Hospital   (Italy)

^d Azienda Ospedaliera Universitaria Senese santa Maria Alle Scotte   (Italy)

Author keywords

Carotid artery disease; Carotid plaques; Echo Doppler; Fatty liver; Metabolic liver disease

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CAROTID ARTERY DISEASE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE ASSOCIATION; ECHOGRAPHY; FATTY LIVER; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEPATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; CAROTID ARTERY DISEASES; FATTY LIVER; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HOMEOSTASIS; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK FACTORS; ULTRASONOGRAPHY, DOPPLER;

EID: 73449141079     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-009-0125-8     Document Type: Article

References (32)

1. J Ludwig TR Viggiano DB McGill BJ Ott 1980 Nonalcoholic steatohepatitis Mayo Clin Proc 55 434 438 1:STN:280:DyaL3c3gvVeqtQ%3D%3D 7382552
2. J Medina LI Fernandez-Salazar L Garcia-Buey R Moreno-Otero 2004 Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis Diabetes Care 27 2057 2066 10.2337/diacare.27.8.2057 15277442 (Pubitemid 38989257)
3. A Brea D Mosquera E Martin A Arizti JL Cordero E Ros 2005 Nonalcoholic fatty liver diseases is associated with carotid atherosclerosis: a case-control study Arterioscler Thromb Vasc Biol 25 1045 1050 10.1161/01.ATV.0000160613. 57985.18 1:CAS:528:DC%2BD2MXjsVCjtL8%3D 15731489 (Pubitemid 40627853)
4. G Targher L Bertolini R Padovani L Zenari G Zoppini G Falezza 2004 Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men Diabetes Care 27 2498 2500 10.2337/diacare.27.10.2498 15451925 (Pubitemid 39281410)
5. H Volzke DM Robinson V Kleine R Deutscher W Hoffmann J Lüdemann, et al. 2005 Hepatic steatosis is associated with an increased risk of carotid atherosclerosis World J Gastroenterol 11 1848 1853 15793879
6. G Targher L Bertolini F Poli S Rodella L Scala R Tessari, et al. 2005 Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients Diabetes 54 3541 3546 10.2337/diabetes.54.12.3541 1:CAS:528:DC%2BD2MXht12gsL%2FN 16306373 (Pubitemid 43334347)
7. G Targher L Bertolini R Padovani F Poli L Scala R Tessari, et al. 2006 Increased prevalence of cardiovascular disease in type 2 diabetic patients with non-alcoholic fatty liver disease Diabet Med 23 403 409 10.1111/j.1464-5491. 2006.01817.x 1:STN:280:DC%2BD283hs1ensQ%3D%3D 16620269
8. G Targher L Bertolini S Rodella R Tessari L Zenari G Lippi, et al. 2007 Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients Diabetes Care 30 2119 2121 10.2337/dc07-0349 1:CAS:528:DC%2BD2sXpsleks7Y%3D 17519430 (Pubitemid 47219432)
9. G Targher L Bertolini R Padovani F Poli L Scala L Zenari, et al. 2006 Non-alcoholic fatty liver disease is associated with carotid artery wall thickness in diet-controlled type 2 diabetic patients J Endocrinol Invest 29 55 60 1:STN:280:DC%2BD287msVWrsg%3D%3D 16553034 (Pubitemid 43355836)
10. RL McKimmie KR Daniel JJ Carr DW Bowden BI Freedman TC Register FC Hsu KK Lohman RB Weinberg LE Wagenknecht 2008 Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study Am J Gastroenterol 103 3029 3035 10.1111/j.1572-0241.2008.02188.x 1:CAS:528:DC%2BD1MXmt1OqtA%3D%3D 18853970
11. RK Schindhelm M Diamant SJ Bakker RA van Dijk PG Scheffer T Teerlink, et al. 2005 Liver aminotranferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus Eur J Clin Invest 35 369 374 10.1111/j.1365-2362.2005.01502.x 1:CAS:528: DC%2BD2MXmtFakurk%3D 15948897 (Pubitemid 40826835)
12. N Villanova S Moscatiello S Ramilli E Bugianesi D Magalotti E Vanni, et al. 2005 Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease Hepatology 42 473 480 10.1002/hep.20781 15981216 (Pubitemid 41061101)
13. R Lautamaki R Borra P Iozzo M Komu T Lehtimaki M Salmi, et al. 2006 Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes Am J Physiol Endocrinol Metab 291 E 282 E 290 10.1152/ajpendo.00604.2005 1:CAS:528:DC%2BD28XovVWgt74%3D (Pubitemid 44035287)
14. D Prati E Taioli A Zanella E Della Torre S Butelli E Del Vecchio, et al. 2002 Updated definitions of healthy ranges for serum alanine aminotransferase levels Ann Intern Med 137 1 9 1:CAS:528:DC%2BD38Xls1entbc%3D 12093239
15. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419 10.1007/BF00280883 1:CAS:528:DyaL2MXlslKnu7k%3D 3899825 (Pubitemid 15018832)
16. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486-97.
17. A Gnasso C Irace C Carallo MS De Franceschi C Motti PL Mattioli, et al. 1997 In vivo association between low wall shear stress and plaque in subjects with asymmetrical carotid atherosclerosis Stroke 28 993 998 1:STN:280: DyaK2szgt1akuw%3D%3D 9158640
18. GN Ioannou NS Weiss EJ Boyko D Mozaffarian SP Lee 2006 Elevated serum alanine aminotrasferase activity and calculated risk of coronary heart disease in the United States Hepatology 43 1145 1151 10.1002/hep.21171 1:CAS:528:DC%2BD28XkvFGmtb8%3D 16628637 (Pubitemid 43724639)
19. DS Lee JC Evans SJ Robins PW Wilson I Albano CS Fox, et al. 2007 Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study Arterioscler Thromb Vasc Biol 27 127 133 10.1161/01.ATV.0000251993.20372.40 1:CAS:528:DC%2BD28XhtlSrsb%2FO 17095717 (Pubitemid 46360389)
20. A Fraser R Harris N Sattar S Ebrahim GD Smith DA Lawlor 2007 Gamma-glutamyl transferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis Arterioscler Thromb Vasc Biol 27 2729 2735 10.1161/ATVBAHA.107.152298 1:CAS:528:DC%2BD2sXhtlahtLvP 17932318 (Pubitemid 350158929)
21. RK Schindhelm JM Dekker G Nijpels LM Bouter CD Stehouwer RJ Heine, et al. 2007 Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn study Atherosclerosis 191 391 396 10.1016/j. atherosclerosis.2006.04.006 1:CAS:528:DC%2BD2sXjtFGqsro%3D 16682043 (Pubitemid 46400701)
22. S Sookoian CJ Pirola 2008 Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review J Hepatol 49 600 607 10.1016/j.jhep.2008.06.012 18672311
23. L Pacifico V Cantisani P Ricci JF Osborn E Schiavo C Anania, et al. 2008 Nonalcoholic fatty liver disease and carotid atherosclerosis in children Pediatr Res 63 423 427 10.1203/PDR.0b013e318165b8e7 1:CAS:528:DC%2BD1cXjt1eksbg%3D 18356751
24. AJ Hanley K Williams A Festa LE Wagenknecht RB D'Agostino Jr J Kempf, et al. 2004 Elevations in markers of liver injury and risk of type 2 diabetes: the Insulin Resistance Atherosclerosis Study Diabetes 53 2623 2632 10.2337/diabetes.53.10.2623 1:CAS:528:DC%2BD2cXotFymt78%3D 15448093 (Pubitemid 39299271)
25. M Nannipieri C Gonzales S Baldi R Posadas K Williams SM Haffner, et al. 2005 Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study Diabetes Care 28 1757 1762 10.2337/diacare.28.7.1757 1:CAS:528:DC%2BD2MXms12nurw%3D 15983331 (Pubitemid 40923089)
26. Strasak AM, Kelleher CC, Klenk J, Brant LJ, Ruttmann E, Rapp K, Concin H, Diem G, Pfeiffer KP, Ulmer H, Vorarlberg Health Monitoring and Promotion Program Study Group. Longitudinal change in serum gamma-glutamyltransferase and cardiovascular disease mortality: a prospective population-based study in 76,113 Austrian adults. Arterioscler Thromb Vasc Biol. 2008;28:1857-65.
27. SM Grundy 2007 Gamma-glutamyl transferase: another biomarker for metabolic syndrome and cardiovascular risk Arterioscler Thromb Vasc Biol 27 4 7 10.1161/01.ATV.0000253905.13219.4b 1:CAS:528:DC%2BD2sXhtVygsrg%3D 17185620 (Pubitemid 46360374)
28. M Emdin A Pompella A Paolicchi 2005 Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque Circulation 112 2078 2080 10.1161/CIRCULATIONAHA.105.571919 16203922 (Pubitemid 41475797)
29. S Tamura I Shimomura 2005 Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease J Clin Invest 115 1139 1142 10.1172/JCI200524930 1:CAS:528:DC%2BD2MXktFSktr0%3D 15864343 (Pubitemid 40629030)
30. ZT Bloomgarden 2005 Second World Congress on the insulin resistance syndrome Diabetes Care 28 1518 1523 10.2337/diacare.28.6.1518 15920084 (Pubitemid 40756729)
31. E Bugianesi U Pagotto R Manini E Vanni A Gastaldelli R de Iasio, et al. 2005 Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity J Clin Endocrinol Metab 90 3498 3504 10.1210/jc.2004-2240 1:CAS:528: DC%2BD2MXkvFCltLs%3D 15797948 (Pubitemid 41014319)
32. J Yamada H Tomiyama M Yambe Y Koji K Motobe K Shiina, et al. 2006 Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome Atherosclerosis 189 198 205 10.1016/j.atherosclerosis.2005.11.036 1:CAS:528:DC%2BD28XhtVajsr3F 16405892 (Pubitemid 44441282)