Shortfalls of the use of HbA1C-derived eAG in older adults with diabetes

Diabetes Research and Clinical Practice

Volumn 110, Issue 1, 2015, Pages 60-65

  Munshi, M N ^a,b,c   Segal, A R ^a,d   Slyne, C ^a   Samur, A A ^e   Brooks, K M ^f   Horton, E S ^a,c  

^a JOSLIN DIABETES CENTER   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^e AKDENIZ UNIVERSITY   (Turkey)

^f TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Estimated average glucose (eAG); HbA1c; Older adults

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

AGED; ARTICLE; BLOOD GLUCOSE MONITORING; ESTIMATED AVERAGE GLUCOSE CONCENTRATION; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MEAN AMPLITUDE OF GLYCEMIC EXCURSION; NON INSULIN DEPENDENT DIABETES MELLITUS; AGING; ANALYSIS; BLOOD; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; PREDICTIVE VALUE; PROCEDURES; RETROSPECTIVE STUDY; STANDARDS; STATISTICS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BLOOD GLUCOSE; BLOOD GLUCOSE SELF-MONITORING; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; STATISTICS AS TOPIC;

EID: 84943199157     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2015.07.012     Document Type: Article

References (28)

1. Standards of medical care in diabetes - 2014. Diabetes Care 2014, 37(Suppl. 1):S14-S80.
2. The Diabetes Control and Complications Trial Research Group The effect of intensive treatment of diabetes on the development, progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993, 329(14):977-986.
3. Stratton I.M., Adler A.I., Neil H.A., Matthews D.R., Manley S.E., Cull C.A., et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000, 321(7258):405-412.
4. Nathan D.M., Kuenen J., Borg R., Zheng H., Schoenfeld D., Heine R.J. Translating the A1C assay into estimated average glucose values. Diabetes Care 2008, 31(8):1473-1478.
5. Cohen R.M. A1C: does one size fit all?. Diabetes Care 2007, 30(10):2756-2758.
6. Wolffenbuttel B.H., Herman W.H., Gross J.L., Dharmalingam M., Jiang H.H., Hardin D.S. Ethnic differences in glycemic markers in patients with type 2 diabetes. Diabetes Care 2013, 36(10):2931-2936.
7. Ziemer D.C., Kolm P., Weintraub W.S., Vaccarino V., Rhee M.K., Twombly J.G., et al. Glucose-independent, black-white differences in hemoglobin A1c levels: a cross-sectional analysis of 2 studies. Ann Intern Med 2010, 152(12):770-777.
8. Herman W.H., Cohen R.M. Hemoglobin A1c: teaching a new dog old tricks. Ann Intern Med 2010, 152(12):815-817.
9. Munshi M.N., Segal A.R., Suhl E., Ryan C., Sternthal A., Giusti J., et al. Assessment of barriers to improve diabetes management in older adults: a randomized controlled study. Diabetes Care 2013, 36(3):543-549.
10. Munshi M.N.S.A., Ryan C., Slyne C., Saul N. Simplification of insulin regimens in older adutls with dibetes decreases hypoglycemia, without worsening glycemic control 2013, 390. Scientific Sessions of the American Diabetes Association, Chicago, IL.
11. Service F.J. Glucose variability. Diabetes 2013, 62(5):1398-1404.
12. DeVries J.H. Glucose variability: where it is important and how to measure it. Diabetes 2013, 62(5):1405-1408.
13. Kohnert K.D., Augstein P., Heinke P., Zander E., Peterson K., Freyse E.J., et al. Chronic hyperglycemia but not glucose variability determines HbA1c levels in well-controlled patients with type 2 diabetes. Diabetes Res Clin Pract 2007, 77(3):420-426.
14. National diabetes statistics report: estimates of diabetes and its burden in the United States 2014, CDC, Services DoHaH, Atlanta, GA, USA.
15. Dubowitz N., Xue W., Long Q., Ownby J.G., Olson D.E., Barb D., et al. Aging is associated with increased HbA levels, independently of glucose levels and insulin resistance, and also with decreased HbA diagnostic specificity. Diabet Med 2014, 31(8):927-935. 10.1111/dme.12459.
16. Pani L.N., Korenda L., Meigs J.B., Driver C., Chamany S., Fox C.S., et al. Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004. Diabetes Care 2008, 31(10):1991-1996.
17. Nitin S. HbA1c and factors other than diabetes mellitus affecting it. Singap Med J 2010, 51(8):616-622.
18. Sharif A., Baboolal K. Diagnostic application of the A(1c) assay in renal disease. J Am Soc Nephrol 2010, 21(3):383-385.
19. Brown J.N., Kemp D.W., Brice K.R. Class effect of erythropoietin therapy on hemoglobin A(1c) in a patient with diabetes mellitus and chronic kidney disease not undergoing hemodialysis. Pharmacotherapy 2009, 29(4):468-472.
20. Launer L.J., Miller M.E., Williamson J.D., Lazar R.M., Gerstein H.C., Murray A.M., et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol 2011, 10(11):969-977.
21. Patel A., MacMahon S., Chalmers J., Neal B., Billot L., Woodward M., et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008, 358(24):2560-2572.
22. Duckworth W., Abraira C., Moritz T., Reda D., Emanuele N., Reaven P.D., et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009, 360(2):129-139.
23. Munshi M.N., Segal A.R., Suhl E., Staum E., Desrochers L., Sternthal A., et al. Frequent hypoglycemia among elderly patients with poor glycemic control. Arch Intern Med 2011, 171(4):362-364.
24. Brownlee M., Hirsch I.B. Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications. JAMA 2006, 295(14):1707-1708.
25. Rizzo M.R., Marfella R., Barbieri M., Boccardi V., Vestini F., Lettieri B., et al. Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients. Diabetes Care 2010, 33(10):2169-2174.
26. Monnier L., Wojtusciszyn A., Colette C., Owens D. The contribution of glucose variability to asymptomatic hypoglycemia in persons with type 2 diabetes. Diabetes Technol Ther 2011, 13(8):813-818.
27. Fang F.S., Li Z.B., Li C.L., Tian H., Li J., Cheng X.L. Influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes. Intern Med 2012, 51(22):3109-3113.
28. Sartore G., Chilelli N.C., Burlina S., Di Stefano P., Piarulli F., Fedele D., et al. The importance of HbA1c and glucose variability in patients with type 1 and type 2 diabetes: outcome of continuous glucose monitoring (CGM). Acta Diabetol 2012, 49(Suppl. 1):S153-S160.