Development and validation of a next-generation sequencing assay for BRCA1 and BRCA2 variants for the clinical laboratory

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Strom, Charles M ^a   Rivera, Steven ^a   Elzinga, Christopher ^b   Angeloni, Taraneh ^a   Rosenthal, Sun Hee ^a   Goos Root, Dana ^a   Siaw, Martin ^a   Platt, Jamie ^a   Braastadt, Cory ^b   Cheng, Linda ^a   Ross, David ^a   Sun, Weimin ^a  

^a QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

^b ATHENA DIAGNOSTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; GENOMIC DNA; BRCA1 PROTEIN, HUMAN; BRCA2 PROTEIN, HUMAN;

ARTICLE; BASE PAIRING; CLINICAL LABORATORY; COMPUTER PROGRAM; CONTROLLED STUDY; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HYBRIDIZATION; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NEXT GENERATION SEQUENCING; SENSITIVITY AND SPECIFICITY; STEM CELL; TUMOR SUPPRESSOR GENE; VALIDATION PROCESS; BIOASSAY; BREAST NEOPLASMS; COMPUTER INTERFACE; DEVICES; DNA SEQUENCE; FEMALE; GENETIC SCREENING; GENETICS; HIGH THROUGHPUT SEQUENCING; MUTATION; PROCEDURES; TUMOR CELL LINE;

BIOLOGICAL ASSAY; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENETIC TESTING; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MUTATION; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA; USER-COMPUTER INTERFACE;

EID: 84943151641     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136419     Document Type: Article

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