Mechanisms and management of refractory coeliac disease

Nature Reviews Gastroenterology and Hepatology

Volumn 12, Issue 10, 2015, Pages 572-579

  Van Gils, Tom ^a   Nijeboer, Petula ^a   Van Wanrooij, Roy L ^a   Bouma, Gerd ^a   Mulder, Chris J J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AZATHIOPRINE; BUDESONIDE; CLADRIBINE; CYCLOSPORIN A; INFLIXIMAB; INTERLEUKIN 15; MESALAZINE; OLMESARTAN; PREDNISONE; TIOGUANINE;

AUTOIMMUNE DISEASE; AUTOIMMUNE ENTEROPATHY; AUTOLOGOUS STEM CELL TRANSPLANTATION; CELIAC DISEASE; CLINICAL FEATURE; COLLAGENOUS SPRUE; COMMON VARIABLE IMMUNODEFICIENCY; DISEASE ACTIVITY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DISEASE SURVEILLANCE; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; ENDOSCOPY; ENTEROPATHY; ENTEROPATHY ASSOCIATED T CELL LYMPHOMA; FLOW CYTOMETRY; GIARDIASIS; GLUTEN FREE DIET; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MOLECULAR PATHOLOGY; NUTRITIONAL SUPPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REFRACTORY CELIAC DISEASE; REVIEW; TREATMENT PLANNING; DECISION TREE;

CELIAC DISEASE; DECISION TREES; HUMANS;

EID: 84942986447     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2015.155     Document Type: Review

References (70)

1. Castillo, N. E., Theethira, T. G. & Leffler, D. A. The present and the future in the diagnosis and management of celiac disease. Gastroenterol. Rep. (Oxf.) 3, 3-11 (2014).
2. Al-Toma, A., Verbeek, W. H. & Mulder, C. J. Update on the management of refractory coeliac disease. J. Gastrointest. Liver Dis. 16, 57-63 (2007).
3. Wahab, P. J., Meijer, J. W. & Mulder, C. J. Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. Am. J. Clin. Pathol. 118, 459-463 (2002).
4. Lanzini, A. et al. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. Aliment. Pharmacol. Ther. 29, 1299-1308 (2009).
5. Kaukinen, K. et al. Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment. Pharmacol. Ther. 25, 1237-1245 (2007).
6. United European Gastroenterology. When is a coeliac a coeliac? Report of a working group of the United European Gastroenterology Week in Amsterdam. Eur. J. Gastroenterol. Hepatol. 13, 1123-1128 (2001).
7. Al-Toma, A., Verbeek, W. H., Hadithi, M, von Blomberg, B. M. & Mulder, C. J. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut 56, 1373-1378 (2007).
8. Rubio-Tapia, A. et al. Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology 136, 99-107 (2009).
9. Malamut, G. et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 136, 81-90 (2009).
10. West, J. Celiac disease and its complications: a time traveller's perspective. Gastroenterology 136, 32-34 (2009).
11. Roshan, B. et al. The incidence and clinical spectrum of refractory celiac disease in a North American referral center. Am. J. Gastroenterol. 106, 923-928 (2011).
12. Wolters, V. M. & Wijmenga, C. Genetic background of celiac disease and its clinical implications. Am. J. Gastroenterol. 103, 190-195 (2008).
13. Al-Toma, A. et al. Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma. Clin. Gastroenterol. Hepatol. 4, 315-319 (2006).
14. Di, S. A., Biagi, F., Gobbi, P. G. & Corazza, G. R. How I treat enteropathy-associated T-cell lymphoma. Blood 119, 2458-2468 (2012).
15. Tack, G. J., Verbeek, W. H., Schreurs, M. W. & Mulder, C. J. The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat. Rev. Gastroenterol. Hepatol. 7, 204-213 (2010).
16. Malamut, G., Meresse, B., Cellier, C. & Cerf-Bensussan, N. Refractory celiac disease: from bench to bedside. Semin. Immunopathol. 34, 601-613 (2012).
17. Verbeek, W. H. et al. Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in refractory celiac disease. Clin. Immunol. 126, 48-56 (2008).
18. Tack, G. J. et al. Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study. BMC Gastroenterol. 12, 159 (2012).
19. Cellier, C. et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology 114, 471-481 (1998).
20. Schmitz, F. et al. Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II. Gut 62, 509-519 (2013).
21. Mention, J. J. et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 125, 730-745 (2003).
22. Colpitts, S. L. et al. Cutting edge: the role of IFN-alpha receptor and MyD88 signaling in induction of IL-15 expression in vivo. J. Immunol. 188, 2483-2487 (2012).
23. Rubio-Tapia, A. & Murray, J. A. Classification and management of refractory coeliac disease. Gut 59, 547-557 (2010).
24. Al-Toma, A., Verbeek, W. H. & Mulder, C. J. The management of complicated celiac disease. Dig. Dis. 25, 230-236 (2007).
25. Daum, S., Cellier, C. & Mulder, C. J. Refractory coeliac disease. Best Pract. Res. Clin. Gastroenterol. 19, 413-424 (2005).
26. Hadithi M et al. Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease. Ann. Intern. Med. 147, 294-302 (2007).
27. Vahedi, K. et al. Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. Am. J. Gastroenterol. 98, 1079-1087 (2003).
28. [No authors listed]. Giardia lamblia and coeliac disease. Lancet 302, 138 (1973).
29. Mulder, C. J., Wahab, P. J., Moshaver, B. & Meijer, J. W. Refractory coeliac disease: a window between coeliac disease and enteropathy associated T cell lymphoma. Scand. J. Gastroenterol. Suppl. 2000, 32-37 (2000).
30. Abolhassani, H. et al. A review on guidelines for management and treatment of common variable immunodeficiency. Expert Rev. Clin. Immunol. 9, 561-574 (2013).
31. Rubio-Tapia, A., Talley, N. J., Gurudu, S. R., Wu, T. T. & Murray, J. A. Gluten-free diet and steroid treatment are effective therapy for most patients with collagenous sprue. Clin. Gastroenterol. Hepatol. 8, 344-349 (2010).
32. Gopal, P. & McKenna, B. J. The collagenous gastroenteritides: similarities and differences. Arch. Pathol. Lab. Med. 134, 1485-1489 (2010).
33. Gentile, N. M., Murray, J. A. & Pardi, D. S. Autoimmune enteropathy: a review and update of clinical management. Curr. Gastroenterol. Rep. 14, 380-385 (2012).
34. Masia, R., Peyton, S., Lauwers, G. Y. & Brown, I. Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases. Am. J. Surg. Pathol. 38, 1319-1329 (2014).
35. Bhat, N., Anupama, N. K., Yelsangikar, A. & Vizhi, K. Olmesartan-related sprue-like enteropathy. Indian J. Gastroenterol. 33, 564-567 (2014).
36. Heerasing, N., Hair, C. & Wallace, S. Olmesartan-induced enteropathy. Intern. Med. J. 45, 117-118 (2015).
37. van Beurden, Y. H., Nijeboer, P., Janssen, J., Verbeek, W. H. & Mulder, C. J. Diarrhoea and malabsorption due to olmesartan use [Dutch]. Ned. Tijdschr. Geneeskd. 158, A7370 (2014).
38. Verbeek, W. H. et al. Incidence of enteropathy - associated T-cell lymphoma: a nation-wide study of a population-based registry in The Netherlands. Scand. J. Gastroenterol. 43, 1322-1328 (2008).
39. Van Weyenberg, S. J., Smits, F., Jacobs, M. A., Van Turenhout, S. T. & Mulder, C. J. Video capsule endoscopy in patients with nonresponsive celiac disease. J. Clin. Gastroenterol. 47, 393-399 (2012).
40. Hadithi, M. et al. The value of double-balloon enteroscopy in patients with refractory celiac disease. Am. J. Gastroenterol. 102, 987-996 (2007).
41. Mallant, M. et al. Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma. World J. Gastroenterol. 13, 1696-1700 (2007).
42. Van Weyenberg, S. J. et al. Double-balloon endoscopy as the primary method for small-bowel video capsule endoscope retrieval. Gastrointest. Endosc. 71, 535-541 (2010).
43. Van Weyenberg, S. J. et al. Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease. Abdom. Imaging 38, 42-51 (2013).
44. Daum, S. et al. Capsule endoscopy in refractory celiac disease. Endoscopy 39, 455-458 (2007).
45. Hadithi, M. et al. 18F-FDG PET versus CT for the detection of enteropathy-associated T-cell lymphoma in refractory celiac disease. J. Nucl. Med. 47, 1622-16227 (2006).
46. Nijeboer P, van Wanrooij, R. L., Tack, G. J., Mulder, C. J. & Bouma, G. Update on the diagnosis and management of refractory coeliac disease. Gastroenterol. Res. Pract. 2013, 518483 (2013).
47. van Wanrooij, R. L. et al. Accurate classification of RCD requires flow cytometry. Gut 59, 1732 (2010).
48. van Wanrooij, R. L. et al. Optimal strategies to identify aberrant intra-epithelial lymphocytes in refractory coeliac disease. J. Clin. Immunol. 34, 828-835 (2014).
49. Brar, P., Lee, S., Lewis, S., Egbuna, I., Bhagat, G. & Green, P. H. Budesonide in the treatment of refractory celiac disease. Am. J. Gastroenterol. 102, 2265-2269 (2007).
50. Jamma, S. et al. Small intestinal release mesalamine for the treatment of refractory celiac disease type I. J. Clin. Gastroenterol. 45, 30-33 (2011).
51. Goerres, M. S. et al. Azathioprine and prednisone combination therapy in refractory coeliac disease. Aliment Pharmacol. Ther. 18, 487-494 (2003).
52. Gillett, H. R. et al. Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gastroenterology 122, 800-805 (2002).
53. Costantino, G. et al. Treatment of life-threatening type I refractory coeliac disease with long-term infliximab. Dig. Liver Dis. 40, 74-77 (2008).
54. Tack, G. J., van Asseldonk, D. P., van Wanrooij, R. L., van Bodegraven, A. A. & Mulder, C. J. Tioguanine in the treatment of refractory coeliac disease - a single centre experience. Aliment. Pharmacol. Ther. 36, 274-281 (2012).
55. Malamut, G. et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 136, 81-90 (2009).
56. Al-Toma, A. et al. Cladribine therapy in refractory celiac disease with aberrant T cells. Clin. Gastroenterol. Hepatol. 4, 1322-1327 (2006).
57. Robak, T., Wierzbowska, A. & Robak, E. Recent clinical trials of cladribine in hematological malignancies and autoimmune disorders. Rev. Recent Clin. Trials 1, 15-34 (2006).
58. Al-Toma, A. et al. Cladribine therapy in refractory celiac disease with aberrant T cells. Clin. Gastroenterol. Hepatol. 4, 1322-1327 (2006).
59. Tack, G. J. et al. Evaluation of Cladribine treatment in refractory celiac disease type II. World J. Gastroenterol. 17, 506-513 (2011).
60. Al-Toma, A., Nijeboer, P., Bouma, G., Visser, O. & Mulder, C. J. Hematopoietic stem cell transplantation for non-malignant gastrointestinal diseases. World J. Gastroenterol. 20, 17368-17375 (2014).
61. Al-Toma, A. et al. Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells. Blood 109, 2243-2249 (2007).
62. Tack, G. J. et al. Auto-SCT in refractory celiac disease type II patients unresponsive to cladribine therapy. Bone Marrow Transplant 46, 840-846 (2011).
63. Wahab, P. J., Crusius, J. B., Meijer, J. W., Uil, J. J. & Mulder, C. J. Cyclosporin in the treatment of adults with refractory coeliac disease - an open pilot study. Aliment. Pharmacol. Ther. 14, 767-774 (2000).
64. Al-Toma, A., Verbeek, W. H., Hadithi M, von Blomberg, B. M. & Mulder, C. J. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut 56, 1373-1378 (2007).
65. Gale, J., Simmonds, P. D., Mead, G. M., Sweetenham, J. W. & Wright, D. H. Enteropathy-type intestinal T-cell lymphoma: clinical features and treatment of 31 patients in a single center. J. Clin. Oncol. 18, 795-803 (2000).
66. van de Water, J. M. et al. Enteropathy associated T-cell lymphoma and its precursor lesions. Best Pract. Res. Clin. Gastroenterol. 24, 43-56 (2010).
67. Nijeboer, P. et al. Therapy in RCDII: Rationale for Combination Strategies? Dig. Dis. 33, 227-230 (2015).
68. Malamut, G. et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J. Clin. Invest. 120, 2131-2143 (2010).
69. van der, H. D. et al. Tofacitinib (CP-690550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum. 65, 559-570 (2013).
70. van Vollenhoven, R. F. et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N. Engl. J. Med. 367, 508-519 (2012).