Pancreatic triacylglycerol distribution in type 2 diabetes

Diabetologia

Volumn 58, Issue 11, 2015, Pages 2676-2678

  Hollingsworth, Kieren G ^a   Al Mrabeh, Ahmad ^a   Steven, Sarah ^a   Taylor, Roy ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Ectopic fat; Magnetic resonance imaging; Pancreas; Pancreatic steatosis; Type 2 diabetes

Indexed keywords

FATTY ACID; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOSE TISSUE; FAT CONTENT; HUMAN; LETTER; LIPOLYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS; PANCREAS CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STEATOSIS; FEMALE; MALE; PANCREAS DISEASE; PATHOLOGY;

ADIPOSE TISSUE; FEMALE; HUMANS; INSULIN-SECRETING CELLS; MALE; PANCREAS; PANCREATIC DISEASES;

EID: 84942982051     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3718-1     Document Type: Letter

References (10)

1. Begovatz P, Koliaki C, Weber K et al (2015) Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans. Diabetologia 58:1646–1655
2. Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R (2011) Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 54:2506–2514
3. Hu HH, Kim HW, Nayak KS, Goran MI (2010) Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity 18:841–847
4. Macauley M, Percival K, Thelwall PE, Hollingsworth KG, Taylor R (2015) Altered volume, morphology and composition of the pancreas in type 2 diabetes. PLoS One 10:e0126825
5. Hollingsworth KG (2014) Quantitative MRI in muscular dystrophy: an indispensable trial endpoint? Neurology 83:956–957
6. Hollingsworth KG, Higgins DM, McCallum M, Ward L, Coombs A, Straub V (2014) Investigating the quantitative fidelity of prospectively undersampled chemical shift imaging in muscular dystrophy with compressed sensing and parallel imaging reconstruction. Magn Reson Med 72:1610–1619
7. Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA (2008) Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity 16:522–530
8. Lee Y, Lingvay I, Szczepaniak LS, Ravazzola M, Orci L, Unger RH (2010) Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents. Int J Obes (Lond) 34:396–400
9. Lalloyer F, Vandewalle B, Percevault F et al (2006) Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes 55:1605–1613
10. Dobbins RL, Szczepaniak LS, Myhill J et al (2002) The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. Diabetes 51:1825–1833