Loss of RACK1 promotes metastasis of gastric cancer by inducing a miR-302c/IL8 signaling loop

Cancer Research

Volumn 75, Issue 18, 2015, Pages 3832-3841

  Chen, Ling ^a   Min, Lingqiang ^a   Wang, Xuefei ^a   Zhao, Junjie ^a   Chen, Hua ^b   Qin, Jing ^a   Chen, Weidong ^a   Shen, Zhenbin ^a   Tang, Zhaoqing ^a   Gan, Qiangjun ^a   Ruan, Yuanyuan ^a   Sun, Yihong ^a   Qin, Xinyu ^a   Gu, Jianxin ^a  

^a FUDAN UNIVERSITY   (China)

^b OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; MESSENGER RNA; MICRORNA; MICRORNA 302C; RECEPTOR FOR ACTIVATED C KINASE 1; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; GNB2L1 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8 RECEPTOR; MIRN302 MICRORNA, MOUSE; SMALL INTERFERING RNA; TUMOR PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; EPIGENETICS; GENE LOSS; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RACK1 GENE; SIGNAL TRANSDUCTION; STOMACH CANCER; SURVIVAL TIME; TISSUE MICROARRAY; TUMOR GENE; TUMOR INVASION; TUMOR PROMOTION; UPREGULATION; ANIMAL; AUTOCRINE EFFECT; BAGG ALBINO MOUSE; BIOSYNTHESIS; DEFICIENCY; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MIDDLE AGED; MORTALITY; NUDE MOUSE; PATHOLOGY; PERITONEUM TUMOR; PHYSIOLOGY; SECONDARY; STOMACH TUMOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOCRINE COMMUNICATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GTP-BINDING PROTEINS; HUMANS; INTERLEUKIN-8; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PERITONEAL NEOPLASMS; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN-8; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84942917163     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-3690     Document Type: Article

References (38)

1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.
2. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65:87-108.
3. Washington K. 7th edition of the AJCC cancer staging manual: stomach. Ann Surg Oncol 2010;17:3077-9.
4. Deng JY, Liang H. Clinical significance of lymph node metastasis in gastric cancer. World J Gastroenterol 2014;20:3967-75.
5. Glockzin G, Piso P. Current status and future directions in gastric cancer with peritoneal dissemination. Surg Oncol Clin N Am 2012;21:625-33.
6. Misleh JG, Santoro P, Strasser JF, Bennett JJ. Multidisciplinary management of gastric cancer. Surg Oncol Clin N Am 2013;22:247-64.
7. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
8. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med 2013;19:1423-37.
9. Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007;117:3988-4002.
10. Langley RR, Fidler IJ. The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 2011;128:2527-35.
11. Quante M, Varga J, Wang TC, Greten FR. The gastrointestinal tumor microenvironment. Gastroenterology 2013;145:63-78.
12. Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res 2008;14:6735-41.
13. Mishra P, Banerjee D, Ben-Baruch A. Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy. J Leukoc Biol 2011;89:31-9.
14. Adams DR, Ron D, Kiely PA. RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal 2011;9:22.
15. McCahill A, Warwicker J, Bolger GB, Houslay MD, Yarwood SJ. The RACK1 scaffold protein: a dynamic cog in cell response mechanisms. Mol Pharmacol 2002;62:1261-73.
16. Ruan Y, Sun L, Hao Y, Wang L, Xu J, Zhang W, et al. Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest 2012;122:2554-66.
17. Yu Z, Willmarth NE, Zhou J, Katiyar S, Wang M, Liu Y, et al. microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A 2010;107:8231-6.
18. Matsuoka T, Adair JE, Lih FB, Hsi LC, Rubino M, Eling TE, et al. Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. Br J Cancer 2010;103:1182-91.
19. Lee KH, Bae SH, Lee JL, Hyun MS, Kim SH, Song SK, et al. Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer. Oncology 2004;66:210-7.
20. Asfaha S, Dubeykovskiy AN, Tomita H, Yang X, Stokes S, Shibata W, et al. Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. Gastroenterology 2013;144:155-66.
21. Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, et al. RACK1 suppresses gastric tumorigenesis by stabilizing the beta-catenin destruction complex. Gastroenterology 2012;142:812-23 e15.
22. Levy L, Neuveut C, Renard CA, Charneau P, Branchereau S, Gauthier F, et al. Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem 2002;277:42386-93.
23. Zhu J, Luz-Madrigal A, Haynes T, Zavada J, Burke AK, Del Rio-Tsonis K. beta-Catenin inactivation is a pre-requisite for chick retina regeneration. PLoS One 2014;9:e101748.
24. Wei T, Xu N, Meisgen F, Stahle M, Sonkoly E, Pivarcsi A. Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes. Eur J Dermatol 2013 Apr. 19. [Epub ahead of print].
25. Cullen BR. MicroRNAs as mediators of viral evasion of the immune system. Nat Immunol 2013;14:205-10.
26. Speth C, Laubinger S. RACK1 and the microRNA pathway: Is it deja-vu all over again? Plant Signal Behav 2014;9:e27909.
27. Fabbri E, Borgatti M, Montagner G, Bianchi N, Finotti A, Lampronti I, et al. Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosamediated induction of proinflammatory responses. Am J Respir Cell Mol Biol 2014;50:1144-55.
28. Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, Lu C, et al. Tumour angiogenesis regulation by the miR-200 family. Nat Commun 2013;4:2427.
29. Verbeke H, Geboes K, Van Damme J, Struyf S. The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer. Biochim Biophys Acta 2012;1825:117-29.
30. Zarogoulidis P, Katsikogianni F, Tsiouda T, Sakkas A, Katsikogiannis N, Zarogoulidis K. Interleukin-8 and interleukin-17 for cancer. Cancer Invest 2014;32:197-205.
31. Steiner JL, Davis JM, McClellan JL, Guglielmotti A, Murphy EA. Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3 (1)/SV40Tag mouse model of breast cancer. Cytokine 2014;66:60-8.
32. Weitzenfeld P, Ben-Baruch A. The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer. Cancer Lett 2014;352:36-53.
33. Speth C, Willing EM, Rausch S, Schneeberger K, Laubinger S. RACK1 scaffold proteins influence miRNA abundance in Arabidopsis. Plant J 2013;76:433-45.
34. Chu YD, Wang WC, Chen SA, Hsu YT, Yeh MW, Slack FJ, et al. RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans. Cell Cycle 2014;13:1995-2009.
35. Jannot G, Bajan S, Giguere NJ, Bouasker S, Banville IH, Piquet S, et al. The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep 2011;12:581-6.
36. Barroso-del Jesus A, Lucena-Aguilar G, Menendez P. The miR-302-367 cluster as a potential stemness regulator in ESCs. Cell Cycle 2009;8:394-8.
37. Fareh M, Turchi L, Virolle V, Debruyne D, Almairac F, de-la-Forest Divonne S, et al. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ 2012;19:232-44.
38. Lordick F, Allum W, Carneiro F, Mitry E, Tabernero J, Tan P, et al. Unmet needs and challenges in gastric cancer: the way forward. Cancer Treat Rev 2014;40:692-700.