A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

Journal of Infectious Diseases

Volumn 212, Issue , 2015, Pages S368-S371

  Pyankov, Oleg V ^a   Bodnev, Sergey A ^a   Pyankova, Olga G ^a,b   Solodkyi, Vladislav V ^a   Pyankov, Stepan A ^a   Setoh, Yin Xiang ^b   Volchkova, Valentina A ^d   Suhrbier, Andreas ^b,c   Volchkov, Viktor V ^d   Agafonov, Alexander A ^a   Khromykh, Alexander A ^b  

^a STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

Author keywords

Ebola virus; Kunjin replicon; nonhuman primates; vaccine

Indexed keywords

EBOLA VACCINE; VIRUS GLYCOPROTEIN; GLYCOPROTEIN; VIRAL PROTEIN; VIRUS LIKE PARTICLE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CHLOROCEBUS AETHIOPS; CONTROLLED STUDY; EBOLA HEMORRHAGIC FEVER; FEVER; KUNJIN VIRUS; NONHUMAN; PRIORITY JOURNAL; REPLICON; VIRUS LIKE AGENT; ZAIRE EBOLAVIRUS; AFRICA; ANIMAL; EBOLAVIRUS; IMMUNIZATION; IMMUNOLOGY; PRIMATE; PROCEDURES; WEST NILE VIRUS;

AFRICA, WESTERN; ANIMALS; CERCOPITHECUS AETHIOPS; EBOLA VACCINES; EBOLAVIRUS; GLYCOPROTEINS; HEMORRHAGIC FEVER, EBOLA; IMMUNIZATION; PRIMATES; REPLICON; VACCINES, VIRUS-LIKE PARTICLE; VIRAL PROTEINS; WEST NILE VIRUS;

EID: 84942894469     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv019     Document Type: Article

References (17)

1. Marzi A, Feldmann H. Ebola virus vaccines: an overview of current approaches. Expert Rev Vaccines 2014; 13:521-31.
2. http://www.who.int/mediacentre/factsheets/fs103/en/.
3. http://www.cdc.gov/vhf/ebola/outbreaks/drc/2014-august.html.
4. http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/case-counts. html. Accessed 28 January 2015.
5. Geisbert TW, Daddario-DiCaprio KM,Williams KJ, et al. Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates. J Virol 2008; 82:5664-8.
6. Kanapathipillai R, Restrepo AM, Fast P, et al. Ebola Vaccine-An Urgent International Priority. N Engl J Med 2014; 371:2249-51.
7. Geisbert TW, Geisbert JB, Leung A, et al. Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus. J Virol 2009; 83:7296-304.
8. Stanley DA, Honko AN, Asiedu C, et al. Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge. Nat Med 2014; 20:1126-9.
9. Geisbert TW, Feldmann H. Recombinant vesicular stomatitis virusbased vaccines against Ebola and Marburg virus infections. J Infect Dis 2011; 204(suppl 3):S1075-81.
10. Pijlman GP, Suhrbier A, Khromykh AA. Kunjin virus replicons: an RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applications. Expert Opin Biol Ther 2006; 6:135-45.
11. Harvey TJ, Liu WJ,Wang XJ, et al. Tetracycline-inducible packaging cell line for production of flavivirus replicon particles. J Virol 2004; 78:531-8.
12. Reynard O, Mokhonov V, Mokhonova E, et al. Kunjin virus repliconbased vaccines expressing Ebola virus glycoprotein GP protect the guinea pig against lethal Ebola virus infection. J Infect Dis 2011; 204(suppl 3): S1060-5.
13. Dolnik O, Volchkova V, Garten W, et al. Ectodomain shedding of the glycoprotein GP of Ebola virus. EMBO J 2004; 23:2175-84.
14. Davis KJ, Anderson AO, Geisbert TW, et al. Pathology of experimental Ebola virus infection in African green monkeys. Involvement of fibroblastic reticular cells. Arch Pathol Lab Med 1997; 121:805-19.
15. Ksiazek TG, West CP, Rollin PE, Jahrling PB, Peters CJ. ELISA for the detection of antibodies to Ebola viruses. J Infect Dis 1999; 179(suppl 1): S192-8.
16. Smith LM, Hensley LE, Geisbert TW, et al. Interferon-beta therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. J Infect Dis 2013; 208:310-8.
17. Herbert AS, Kuehne AI, Barth JF, et al. Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus. J Virol 2013; 87:4952-64.