Loss of klotho in CKD breaks one's heart

Journal of the American Society of Nephrology

Volumn 26, Issue 10, 2015, Pages 2305-2307

  Fu, Haiyan ^a,b   Liu, Youhua ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FIBROBLAST GROWTH FACTOR 23; INDICAN; KLOTHO PROTEIN; BETA GLUCURONIDASE;

BLOOD CHEMISTRY; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DYSLIPIDEMIA; EDITORIAL; HEART; HEART FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; KIDNEY FUNCTION; KIDNEY INJURY; MORBIDITY; MORTALITY; NONHUMAN; OBESITY; PREVALENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; RENAL REPLACEMENT THERAPY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK FACTOR; SERUM; ANIMAL; CHRONIC KIDNEY FAILURE; COMPLICATION; FEMALE; HYPERTROPHY, LEFT VENTRICULAR; MALE; PHYSIOLOGY;

ANIMALS; FEMALE; GLUCURONIDASE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; INDICAN; MALE; RENAL INSUFFICIENCY, CHRONIC;

EID: 84942879116     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015020200     Document Type: Editorial

References (15)

1. Tumlin JA, CostanzoMR, Chawla LS, Herzog CA, Kellum JA, McCullough PA, Ronco C: Cardiorenal syndrome type 4: Insights on clinical presentation and pathophysiology from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI). ContribNephrol 182: 158- 173, 2013.
2. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351: 1296-1305, 2004.
3. Zhou L, Li Y, Zhou D, Tan RJ, Liu Y: Loss of Klotho contributes to kidney injury by derepression of Wnt/b-catenin signaling. J Am Soc Nephrol 24: 771-785, 2013.
4. Xie J, Yoon J, An SW, Kuro-O M, Huang CL: Soluble Klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate [published online ahead of print December 4, 2014]. J Am Soc Nephrol doi:ASN.2014040325.
5. Hu MC, Shi M, Zhang J, Quiñones H, Griffith C, Kuro-o M, Moe OW: Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 22: 124-136, 2011.
6. Yang K, Wang C, Nie L, Zhao X, Gu J, Guan X, Wang S, Xiao T, Xu X, He T, Xia X, Wang J, Zhao J: Klotho protects against indoxyl sulphate-induced myocardial hypertrophy. J Am Soc Nephrol 26: 2434-2446, 2015.
7. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L: Plasma klotho and cardiovascular disease in adults.J Am Geriatr Soc 59: 1596-1601, 2011.
8. Niwa T: Targeting protein-bound uremic toxins in chronic kidney disease. Expert Opin Ther Targets 17: 1287-1301, 2013.
9. Kuro-o M: Klotho in health and disease. Curr Opin Nephrol Hypertens 21: 362-368, 2012.
10. Hu MC, Kuro-o M, Moe OW: Klotho and chronic kidney disease. Contrib Nephrol 180: 47-63, 2013.
11. Lindberg K, Amin R, Moe OW, HuMC, Erben RG, Östman Wernerson A, Lanske B, Olauson H, Larsson TE: The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol 25: 2169-2175, 2014.
12. Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M: FGF23 induces left ventricular hypertrophy. J Clin Invest 121: 4393-4408, 2011.
13. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M: Klotho inhibits transforming growth factor-b1 (TGF-b1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286: 8655-8665, 2011.
14. Guan X, Nie L, He T, Yang K, Xiao T, Wang S, Huang Y, Zhang J, Wang J, Sharma K, Liu Y, Zhao J: Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling. J Pathol 234: 560-572, 2014.
15. Zhou L, Li Y, Hao S, Zhou D, Tan RJ, Nie J, Hou FF, Kahn M, Liu Y: Multiple genes of the renin-angiotensin system are novel targets of Wnt/b-catenin signaling. J Am Soc Nephrol 26: 107-120, 2015.