Maternal versus infant Vitamin D supplementation during lactation: A randomized controlled trial

Pediatrics

Volumn 136, Issue 4, 2015, Pages 625-634

  Hollis, Bruce W ^a   Wagner, Carol L ^a   Howard, Cynthia R ^b   Ebeling, Myla ^c   Shary, Judy R ^a   Smith, Pamela G ^a   Taylor, Sarah N ^a   Morella, Kristen ^c   Lawrence, Ruth A ^b   Hulsey, Thomas C ^c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL; CREATININE; PHOSPHORUS; PLACEBO; VITAMIN;

ABSENCE OF SIDE EFFECTS; ADULT; AFRICAN AMERICAN; ARTICLE; BLACK PERSON; BLOOD; BREAST FEEDING; CAUCASIAN; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; FEMALE; HISPANIC; HUMAN; INFANT; INFANT BLOOD; LACTATION; MAJOR CLINICAL STUDY; MATERNAL BLOOD; NUTRITIONAL REQUIREMENT; PRIORITY JOURNAL; PUERPERIUM; RACE DIFFERENCE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; UNITED STATES; URINE LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ADOLESCENT; COMPARATIVE STUDY; DIETARY SUPPLEMENT; MATERNAL WELFARE; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; BREAST FEEDING; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; LACTATION; MATERNAL HEALTH; MIDDLE AGED; VITAMIN D DEFICIENCY; VITAMINS; YOUNG ADULT;

EID: 84942871022     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2015-1669     Document Type: Article

References (55)

1. Food and Nutrition Board. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Vitamin D and Calcium. Washington, DC: National Academy Press; 2010
2. Girish M, Subramaniam G. Rickets in exclusively breast fed babies. Indian J Pediatr. 2008; 75 (6): 641-643
3. Gartner LM, Greer FR; Section on Breastfeeding and Committee on Nutrition. American Academy of Pediatrics. Prevention of rickets and Vitamin D deficiency: New guidelines for Vitamin D intake. Pediatrics. 2003; 111 (4 pt 1): 908-910
4. Kreiter SR, Schwartz RP, Kirkman HN Jr, Charlton PA, Calikoglu AS, Davenport ML. Nutritional rickets in African American breast-fed infants. J Pediatr. 2000; 137 (2): 153-157
5. Greer FR. Issues in establishing Vitamin D recommendations for infants and children. Am J Clin Nutr. 2004; 80 (Suppl 6): 1759S-1762S
6. Specker BL, Tsang RC, Hollis BW. Effect of race and diet on human-milk Vitamin D and 25-hydroxyVitamin D. Am J Dis Child. 1985; 139 (11): 1134-1137
7. Hollis BW, Wagner CL. Vitamin D requirements during lactation: High-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. Am J Clin Nutr. 2004; 80 (Suppl 6): 1752S-1758S
8. Wagner CL, Hulsey TC, Fanning D, Ebeling M, Hollis BW. High-dose Vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: A 6-month follow-up pilot study. Breastfeed Med. 2006; 1 (2): 59-70
9. Widdowson EM. Food intake and growth in the newly-born. Proc Nutr Soc. 1971; 30 (2): 127-135
10. Ziegler EE, Hollis BW, Nelson SE, Jeter JM. Vitamin D deficiency in breastfed infants in Iowa. Pediatrics. 2006; 118 (2): 603-610
11. Wagner CL, Greer FR; American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and Vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008; 122 (5): 1142-1152
12. Taylor JA, Geyer LJ, Feldman KW. Use of supplemental vitamin d among infants breastfed for prolonged periods. Pediatrics. 2010; 125 (1): 105-111
13. Gordon CM, Feldman HA, Sinclair L, et al. Prevalence of Vitamin D deficiency among healthy infants and toddlers. Arch Pediatr Adolesc Med. 2008; 162 (6): 505-512
14. Perrine CG, Sharma AJ, Jefferds ME, Serdula MK, Scanlon KS. Adherence to Vitamin D recommendations among US infants. Pediatrics. 2010; 125 (4): 627-632
15. Ahrens KA, Rossen LM, Simon AE. Adherence to Vitamin D Recommendations Among US Infants Aged 0 to 11 Months, NHANES, 2009 to 2012. Clin Pediatr (Phila). 2015; 0009922815589916
16. Hollis BW, Wagner CL. Assessment of dietary Vitamin D requirements during pregnancy and lactation. Am J Clin Nutr. 2004; 79 (5): 717-726
17. Hollis BW, Wagner CL. Clinical review: The role of the parent compound Vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab. 2013; 98 (12): 4619-4628
18. Greer FR, Hollis BW, Cripps DJ, Tsang RC. Effects of maternal ultraviolet B irradiation on Vitamin D content of human milk. J Pediatr. 1984; 105 (3): 431-433
19. Ala-Houhala M. 25-HydroxyVitamin D levels during breast-feeding with or without maternal or infantile supplementation of Vitamin D. J Pediatr Gastroenterol Nutr. 1985; 4 (2): 220-226
20. Ala-Houhala M, Koskinen T, Terho A, Koivula T, Visakorpi J. Maternal compared with infant Vitamin D supplementation. Arch Dis Child. 1986; 61 (12): 1159-1163
21. Wagner CL, Howard CR, Hulsey TC, et al. Maternal and infant Vitamin D status during lactation: Is latitude important? Health. 2013; 5 (12): 2004
22. Greer FR, Hollis BW, Napoli JL. High concentrations of Vitamin D2 in human milk associated with pharmacologic doses of Vitamin D2. J Pediatr. 1984; 105 (1): 61-64
23. Wagner CL, Howard C, Hulsey TC, et al. Circulating 25-hydroxyvitamin d levels in fully breastfed infants on oral vitamin d supplementation. Int J Endocrinol. 2010; 2010: 235035
24. Labbok MH, Belsey M, Coffin CJ. A call for consistency in defining breast-feeding. Am J Public Health. 1997; 87 (6): 1060-1061
25. Labbok M, Krasovec K. Toward consistency in breastfeeding definitions. Stud Fam Plann. 1990; 21 (4): 226-230
26. Coffin CJ, Labbok MH, Belsey M. Breastfeeding definitions. Contraception. 1997; 55 (6): 323-325
27. Hollis BW. Comparison of equilibrium and disequilibrium assay conditions for ergocalciferol, cholecalciferol and their major metabolites. J Steroid Biochem. 1984; 21 (1): 81-86
28. Hollis BW. Individual quantitation of Vitamin D2, Vitamin D3, 25-hydroxyVitamin D2 and 25-hydroxyVitamin D3 in human milk. Anal Biochem. 1983; 131: 211-219
29. Hollis BW, Pittard WB III. Evaluation of the total fetomaternal Vitamin D relationships at term: Evidence for racial differences. J Clin Endocrinol Metab. 1984; 59 (4): 652-657
30. Hollis BW, Kamerud JQ, Selvaag SR, Lorenz JD, Napoli JL. Determination of Vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem. 1993; 39 (3): 529-533
31. Laboratories MC. Laboratory Reference Data. Rochester, MN: Mayo Clinic; 2004
32. Hollis BW, Wagner CL. Normal serum Vitamin D levels. N Engl J Med. 2005; 352: 515-516
33. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003; 77 (1): 204-210
34. Vieth R. Vitamin D supplementation, 25-hydroxyVitamin D concentrations, and safety. Am J Clin Nutr. 1999; 69 (5): 842-856
35. Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of Vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001; 73 (2): 288-294
36. Hollis BW. Circulating 25-hydroxyVitamin D levels indicative of Vitamin D sufficiency: Implications for establishing a new effective dietary intake recommendation for Vitamin D. J Nutr. 2005; 135 (2): 317-322
37. Vieth R, Ladak Y, Walfish P. Age-related changes in the 25-hydroxyVitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more Vitamin D. J Clin Endocrinal Metab. 2003; 88 (1): 185-191
38. Appelgren KE, Nietert PJ, Hulsey TC, Hollis BW, Wagner CL. Analyzing adherence to prenatal supplement: Does pill count measure up? Int J Endocrinol. 2010; 2010: 631971
39. Food and Nutrition Board. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997
40. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011; 26 (10): 2341-2357
41. Wagner CL, McNeil R, Hamilton SA, et al. A randomized trial of Vitamin D supplementation in 2 community health center networks in South Carolina. Am J Obstet Gynecol. 2013; 208 (2): 137.e1-e13
42. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Guidelines for preventing and treating Vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012; 97 (4): 1153-1158
43. Jackson RD, LaCroix AZ, Gass M, et al; Women's Health Initiative Investigators. Calcium plus Vitamin D supplementation and the risk of fractures. N Engl J Med. 2006; 354 (7): 669-683
44. Nguyen S, Baggerly L, French C, Heaney RP, Gorham ED, Garland CF. 25-HydroxyVitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones. Am J Public Health. 2014; 104 (9): 1783-1787
45. Durup D, Jørgensen HL, Christensen J, Schwarz P, Heegaard AM, Lind B. A reverse J-shaped association of allcause mortality with serum 25-hydroxyVitamin D in general practice: The CopD study. J Clin Endocrinol Metab. 2012; 97 (8): 2644-2652
46. Garland CF, Kim JJ, Mohr SB, et al. Metaanalysis of all-cause mortality according to serum 25-hydroxyVitamin D. Am J Public Health. 2014; 104 (8): E43-e50
47. Luxwolda MF, Kuipers RS, Kema IP, van der Veer E, Dijck-Brouwer DA, Muskiet FA. Vitamin D status indicators in indigenous populations in East Africa. Eur J Nutr. 2013; 52 (3): 1115-1125
48. Luxwolda MF, Kuipers RS, Kema IP, Dijck-Brouwer DA, Muskiet FA. Traditionally living populations in East Africa have a mean serum 25-hydroxyVitamin D concentration of 115 nmol/l. Br J Nutr. 2012; 108 (9): 1557-1561
49. Halliday TM, Peterson NJ, Thomas JJ, Kleppinger K, Hollis BW, Larson-Meyer DE. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med Sci Sports Exerc. 2011; 43 (2): 335-343
50. Hollis BW, Roos BA, Draper HH, Lambert PW. Occurrence of Vitamin D sulfate in human milk whey. J Nutr. 1981; 111 (2): 384-390
51. Reeve LE, Chesney RW, DeLuca HF. Vitamin D of human milk: Identification of biologically active forms. Am J Clin Nutr. 1982; 36 (1): 122-126
52. Oberhelman SS, Meekins ME, Fischer PR, et al. Maternal Vitamin D supplementation to improve the Vitamin D status of breast-fed infants: A randomized controlled trial. Mayo Clin Proc. 2013; 88 (12): 1378-1387
53. Hollis BW, Pittard WB III, Reinhardt TA. Relationships among Vitamin D, 25-hydroxyVitamin D, and Vitamin D-binding protein concentrations in the plasma and milk of human subjects. J Clin Endocrinol Metab. 1986; 62 (1): 41-44
54. Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion. Breastfeeding Among U.S. Children Born 2001-2011, CDC National Immunization Survey. 2015. Available at: Http://www.cdc.gov/breastfeeding/data. Accessed August 6, 2015
55. American Academy of Pediatrics. Committee on Environmental Health. Ultraviolet light: A hazard to children. Pediatrics. 1999; 104 (2 pt 1): 328-333