Amitriptyline for the treatment of fibromyalgia: A comprehensive review

Expert Review of Neurotherapeutics

Volumn 15, Issue 10, 2015, Pages 1123-1150

  Rico Villademoros, Fernando ^a   Slim, Mahmoud ^a   Calandre, Elena P ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

amitriptyline; antidepressants; clinical practice guidelines; fibromyalgia management; randomized clinical trials; review; systematic reviews

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; DULOXETINE; FLUOXETINE; GABAPENTIN; MILNACIPRAN; MOCLOBEMIDE; PIRLINDOLE; PREGABALIN; TRICYCLIC ANTIDEPRESSANT AGENT;

ARTICLE; CHRONIC PAIN; DIZZINESS; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DYSGEUSIA; EXERCISE; FATIGUE; FIBROMYALGIA; GASTROINTESTINAL DISEASE; HEALTH CARE UTILIZATION; HOSPITALIZATION; HUMAN; LOW DRUG DOSE; LOW LEVEL LASER THERAPY; MIGRAINE; NEUROPATHIC PAIN; PAIN; PHARMACODYNAMICS; PHYSIOTHERAPY; PRACTICE GUIDELINE; PROPENSITY SCORE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SLEEP DISORDER; SYSTEMATIC REVIEW (TOPIC); TENSION HEADACHE; XEROSTOMIA; METABOLISM;

AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; FIBROMYALGIA; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84942865998     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2015.1091726     Document Type: Article

References (75)

1. Choy EH. The role of sleep in pain and fibromyalgia. Nat Rev Rheumatol 2015; 11 (9): 513-20
2. Vincent A, Benzo RP, Whipple MO, et al. Beyond pain in fibromyalgia: insights into the symptom of fatigue. Arthritis Res Ther 2013; 15 (6): 221
3. Gracely RH, Ceko M, Bushnell MC. Fibromyalgia and depression. Pain Res Treat 2012; 2012: 486590
4. Glass JM. Fibromyalgia and cognition. J Clin Psychiatry 2008; 69 (Suppl 2): 20-4
5. Slim M, Calandre EP, Rico-Villademoros F. An insight into the gastrointestinal component of fibromyalgia: clinical manifestations and potential underlying mechanisms. Rheumatol Int 2015; 35 (3): 433-44
6. Muto LH, Sauer JF, Yuan SL, et al. Postural control and balance self-efficacy in women with fibromyalgia: are there differences? Eur J Phys Rehabil Med 2015; 51 (2): 149-54
7. Yunus MB. The prevalence of fibromyalgia in other chronic pain conditions. Pain Res Treat 2012; 2012: 584573
8. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 33 (2): 160-72
9. Wolfe F, Clauw DJ, Fitzcharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 2010; 62 (5): 600-10
10. Hauser W, Thieme K, Turk DC. Guidelines on the management of fibromyalgia syndrome-a systematic review. Eur J Pain 2010; 14 (1): 5-10
11. Ablin J, Fitzcharles MA, Buskila D, et al. Treatment of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines with special emphasis on complementary and alternative therapies. Evid Based Complement Alternat Med 2013; 2013: 485272
12. Hauser W, Walitt B, Fitzcharles MA, Sommer C. Review of pharmacological therapies in fibromyalgia syndrome. Arthritis Res Ther 2014; 16 (1): 201
13. Calandre EP, Rico-Villademoros F, Slim M. An update on pharmacotherapy for the treatment of fibromyalgia. Expert Opin Pharmacother 2015; 16 (9): 1347-68
14. Schulz P, Turner-Tamiyasu K, Smith G, et al. Amitriptyline disposition in young and elderly normal men. Clin Pharmacol Ther 1983; 33 (3): 360-6
15. Abaut AY, Chevanne F, Le Corre P. Oral bioavailability and intestinal secretion of amitriptyline: Role of P-glycoprotein? Int J Pharm 2007; 330 (1-2): 121-8
16. Abaut AY, Chevanne F, Le Corre P. Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice. Int J Pharm 2009; 378 (1-2): 80-5
17. Jorgensen A, Hansen V. Pharmacokinetics of amitriptyline infused intravenously in man. Eur J Clin Pharmacol 1976; 10 (5): 337-41
18. Burch JE, Hullin RP. Amitriptyline pharmacokinetics. A crossover study with single doses of amitriptyline and nortriptyline. Psychopharmacol (Berl) 1981; 74 (1): 35-42
19. Kruger R, Holzl G, Kuss HJ, Schefold L. Comparison of the metabolism of the three antidepressants amitriptyline, imipramine, and chlorimipramine in vitro in rat liver microsomes. Psychopharmacology (Berl) 1986; 88 (4): 505-13
20. Rollins DE, Alvan G, Bertilsson L, et al. Interindividual differences in amitriptyline demethylation. Clin Pharmacol Ther 1980; 28 (1): 121-9
21. Venkatakrishnan K, Greenblatt DJ, von Moltke LL, et al. Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J Clin Pharmacol 1998; 38 (2): 112-21
22. Steimer W, Zopf K, von Amelunxen S, et al. Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy. Clin Chem 2005; 51 (2): 376-85
23. Newberry DL, Bass SN, Mbanefo CO. A fluconazole/amitriptyline drug interaction in three male adults. Clin Infect Dis 1997; 24 (2): 270-1
24. Castberg I, Helle J, Aamo TO. Prolonged pharmacokinetic drug interaction between terbinafine and amitriptyline. Ther Drug Monit 2005; 27 (5): 680-2
25. Forget P, le Polain de Waroux B, Wallemacq P, Gala JL. Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. J Pain Symptom Manage 2008; 36 (1): 92-6
26. Mico JA, Ardid D, Berrocoso E, Eschalier A. Antidepressants and pain. Trends Pharmacol Sci 2006; 27 (7): 348-54
27. Verdu B, Decosterd I, Buclin T, et al. Antidepressants for the treatment of chronic pain. Drugs 2008; 68 (18): 2611-32
28. Rosenblatt RM, Reich J, Dehring D. Tricyclic antidepressants in treatment of depression and chronic pain: analysis of the supporting evidence. Anesth Analg 1984; 63 (11): 1025-32
29. Onghena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain 1992; 49 (2): 205-19
30. Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev 2007 (4): CD005454
31. Moore RA, Derry S, Aldington D, et al. Amitriptyline for fibromyalgia in adults. Cochrane Database Syst Rev 2015; 7: CD011824
32. Jackson JL, Shimeall W, Sessums L, et al. Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ 2010; 341: c5222
33. Chao GQ, Zhang S. A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome. Intern Med 2013; 52 (4): 419-24
34. Richards BL, Whittle SL, Buchbinder R. Antidepressants for pain management in rheumatoid arthritis. Cochrane Database Syst Rev 2011 (11): CD008920
35. Wong K, Phelan R, Kalso E, et al. Antidepressant drugs for prevention of acute and chronic postsurgical pain: early evidence and recommended future directions. Anesthesiology 2014; 121 (3): 591-608
36. Carette S, McCain GA, Bell DA, Fam AG. Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study. Arthritis Rheum 1986; 29 (5): 655-9
37. Goldenberg DL, Felson DT, Dinerman H. A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis Rheum 1986; 29 (11): 1371-7
38. Scudds RA, McCain GA, Rollman GB, Harth M. Improvements in pain responsiveness in patients with fibrositis after successful treatment with amitriptyline. J Rheumatol Suppl 1989; 19: 98-103
39. Carette S, Bell MJ, Reynolds WJ, et al. Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial. Arthritis Rheum 1994; 37 (1): 32-40
40. Kempenaers C, Simenon G, Vander Elst M, et al. Effect of an antidiencephalon immune serum on pain and sleep in primary fibromyalgia. Neuropsychobiology 1994; 30 (2-3): 66-72
41. Carette S, Oakson G, Guimont C, Steriade M. Sleep electroencephalography and the clinical response to amitriptyline in patients with fibromyalgia. Arthritis Rheum 1995; 38 (9): 1211-17
42. Ginsberg F, Mancaux A, Joos E, et al. A randomized placebo-controlled trial of sustained-release amitriptyline in primary fibromyalgia. J Musculoskeletal Pain 1996; 4 (3): 37-47
43. Goldenberg D, Mayskiy M, Mossey C, et al. A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. Arthritis Rheum 1996; 39 (11): 1852-9
44. Hannonen P, Malminiemi K, Yli-Kerttula U, et al. A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder. Br J Rheumatol 1998; 37 (12): 1279-86
45. Heymann RE, Helfenstein M, Feldman D. A double-blind, randomized, controlled study of amitriptyline, nortriptyline and placebo in patients with fibromyalgia. An analysis of outcome measures. Clin Exp Rheumatol 2001; 19 (6): 697-702
46. Ataoglu S, Ataoglu A, Erdogan F, Sarac J. Comparison of paroxetine, amitriptyline in the treatment of fibromyalgia. Turkish J Med Sci 1997; 27 (6): 535-9
47. Çapaci K, Hepgüler S. Comparison of the effects of amitriptyline and paroxetine in the treatment of fibromyalgia syndrome. Pain Clinic 2002; 14 (3): 223-8
48. Güleç H, Çapkin E, Sayar K, Ak I. The evaluation of the effectiveness of amitriptyline versus venlafaxine in female patients diagnosed with fibromyalgia syndrome. Klinik Psikofarmakoloji Bulteni 2007; 17 (2): 68-73
49. Konuk N, Ortancil O, Bostanci B, et al. A comparison of reboxetine and amitryptilline in the treatment of fibromyalgia syndrome with co-morbid depressive symptoms: An open-label preliminary study. Klinik Psikofarmakoloji Bulteni 2010; 20 (1): 29-37
50. Erhan E, Uyar M, Turan S, et al. Fluvoxamine versus amitriptyline in the treatment of fibromyalgia. Aʇri 2000; 12 (1): 32-6
51. Calandre EP, Rico-Villademoros F, Galan J, et al. Quetiapine extended-release (Seroquel-XR) versus amitriptyline monotherapy for treating patients with fibromyalgia: a 16-week, randomized, flexible-dose, open-label trial. Psychopharmacology (Berl) 2014; 231 (12): 2525-31
52. Gur A, Karakoc M, Nas K, et al. Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial. Rheumatol Int 2002; 22 (5): 188-93
53. Azad KA, Alam MN, Haq SA, et al. Vegetarian diet in the treatment of fibromyalgia. Bangladesh Med Res Counc Bull 2000; 26 (2): 41-7
54. Vlainich R, Issy AM, Sakata RK. Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. Clin J Pain 2011; 27 (4): 285-8
55. Isomeri R, Mikkelsson M, Latikka P, Kammonen K. Effects of amitriptyline and cardiovascular fitness training on pain in patients with primary fibromyalgia. J Musculoskeletal Pain 1993; 1 (3-4): 253-60
56. Fors EA, Sexton H, Gotestam KG. The effect of guided imagery and amitriptyline on daily fibromyalgia pain: a prospective, randomized, controlled trial. J Psychiatr Res 2002; 36 (3): 179-87
57. Hauser W, Wolfe F, Tolle T, et al. The role of antidepressants in the management of fibromyalgia syndrome: a systematic review and meta-analysis. CNS Drugs 2012; 26 (4): 297-307
58. Hauser W, Petzke F, Uceyler N, Sommer C. Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis. Rheumatology (Oxford) 2011; 50 (3): 532-43
59. Nishishinya B, Urrutia G, Walitt B, et al. Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy. Rheumatology (Oxford) 2008; 47 (12): 1741-6
60. Uceyler N, Hauser W, Sommer C. A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. Arthritis Rheum 2008; 59 (9): 1279-98
61. Hauser W, Bernardy K, Uceyler N, Sommer C. Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis. JAMA 2009; 301 (2): 198-209
62. Smith B, Peterson K, Fu R, et al. Drug class review: drugs for fibromyalgia: final original report [Internet]. Oregon Health & Science University; Portland, OR: 2011
63. Kim SC, Landon JE, Lee YC. Patterns of health care utilization related to initiation of amitriptyline, duloxetine, gabapentin, or pregabalin in fibromyalgia. Arthritis Res Ther 2015; 17: 18
64. Hauser W, Arnold B, Eich W, et al. Management of fibromyalgia syndrome-an interdisciplinary evidence-based guideline. Ger Med Sci 2008; 6: Doc14
65. Carville SF, Arendt-Nielsen L, Bliddal H, et al. EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 2008; 67 (4): 536-41
66. de Miquel CA, Campayo J, Florez MT, et al. Interdisciplinary consensus document for the treatment of fibromyalgia. Actas Esp Psiquiatr 2010; 38 (2): 108-20
67. Fitzcharles MA, Ste-Marie PA, Goldenberg DL, et al. 2012 Canadian Guidelines for the diagnosis and management of fibromyalgia syndrome: executive summary. Pain Res Manag 2013; 18 (3): 119-26
68. Moore RA, Derry S, Aldington D, et al. Amitriptyline for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev 2012; 12: CD008242
69. Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA 1996; 276 (8): 637-9
70. Clauw DJ. Fibromyalgia: a clinical review. JAMA 2014; 311 (15): 1547-55
71. Boyle J, Eriksson ME, Gribble L, et al. Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life. Diabetes Care 2012; 35 (12): 2451-8
72. Calandre EP, Rico-Villademoros F, Rodriguez-Lopez CM. Monotherapy or combination therapy for fibromyalgia treatment? Curr Rheumatol Rep 2012; 14 (6): 568-75
73. Tesfaye S, Wilhelm S, Lledo A, et al. Duloxetine and pregabalin: high-dose monotherapy or their combination? The COMBO-DN study a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain. Pain 2013; 154 (12): 2616-25
74. Bouhassira D, Wilhelm S, Schacht A, et al. Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: data from the randomized, double-blind, COMBO-DN study. Pain 2014; 155 (10): 2171-9
75. Holbech JV, Bach FW, Finnerup NB, et al. Imipramine and pregabalin combination for painful polyneuropathy: a randomized controlled trial. Pain 2015; 156 (5): 958-66