Blockade of angiotensin II type 2 receptor by PD123319 inhibits osteogenic differentiation of human mesenchymal stem cells via inhibition of extracellular signal-regulated kinase signaling

Journal of the American Society of Hypertension

Volumn 9, Issue 7, 2015, Pages 517-525

  Matsushita, Kenichi ^a,b   Wu, Yaojiong ^a   Pratt, Richard E ^a   Dzau, Victor J ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c INSTITUTE OF MEDICINE   (United States)

Author keywords

Calcification; Osteoblast; Osteogenesis; Renin angiotensin system

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR; CALCIUM; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; VALSARTAN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

BLOOD VESSEL CALCIFICATION; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLAST; OSTEOGENIC DIFFERENTIATION; PRIORITY JOURNAL; VASCULARIZATION; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; PHOSPHORYLATION; PYRIDINES; VALSARTAN;

EID: 84942855509     PISSN: 19331711     EISSN: 18787436     Source Type: Journal    
DOI: 10.1016/j.jash.2015.06.006     Document Type: Conference Paper

References (35)

1. Detrano RC, Wong ND, Doherty TM, Shavelle R. Prognostic significance of coronary calcific deposits in asymptomatic high-risk subjects. Am J Med 1997; 102:344-9.
2. Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, et al. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation 2001;104: 412-7.
3. Wayhs R, Zelinger A, Raggi P. High coronary artery calcium scores pose an extremely elevated risk for hard events. J Am Coll Cardiol 2002;39:225-30.
4. Richardson PD, Davies MJ, Born GV. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet 1989;2:941-4.
5. Abedin M, Tintut Y, Demer LL. Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol 2004;24:1161-70.
6. Shao JS, Cai J, Towler DA. Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol 2006;26:1423-30.
7. Abedin M, Tintut Y, Demer LL. Mesenchymal stem cells and the artery wall. Circ Res 2004;95:671-6.
8. Demer LL, Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation 2008;117: 2938-48.
9. Farrington-Rock C, Crofts NJ, Doherty MJ, Ashton BA, Griffin-Jones C, Canfield AE. Chondrogenic and adipogenic potential of microvascular pericytes. Circulation 2004;110:2226-32.
10. Tintut Y, Alfonso Z, Saini T, Radcliff K, Watson K, Bostrom K, et al. Multilineage potential of cells from the artery wall. Circulation 2003;108:2505-10.
11. Hunt JL, Fairman R, Mitchell ME, Carpenter JP, Golden M, Khalapyan T, et al. Bone formation in carotid plaques: a clinicopathological study. Stroke 2002;33:1214-9.
12. Dzau VJ. Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart. Basic Res Cardiol 1993;88(Suppl 1):1-14.
13. Grote K, Drexler H, Schieffer B. Renin-angiotensin system and atherosclerosis. Nephrol Dial Transplant 2004;19:770-3.
14. Mazzolai L, Hayoz D. The renin-angiotensin system and atherosclerosis. Curr Hypertens Rep 2006;8:47-53.
15. Matsushita K, Wu Y, Okamoto Y, Pratt RE, Dzau VJ. Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. Hypertension 2006;48:1095-102.
16. Muruganandan S, Roman AA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci 2009;66:236-53.
17. Nuttall ME, Gimble JM. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 2004;4:290-4.
18. Takada I, Kouzmenko AP, Kato S. Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies. Expert Opin Ther Targets 2009; 13:593-603.
19. Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 2000;275:9645-52.
20. Johansson ME, Fagerberg B, Bergstrom G. Angiotensin type 2 receptor is expressed in human atherosclerotic lesions. J Renin Angiotensin Aldosterone Syst 2008; 9:17-21.
21. Sales VL, Sukhova GK, Lopez-Ilasaca MA, Libby P, Dzau VJ, Pratt RE. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 2005;112:3328-36.
22. Akishita M, Ito M, Lehtonen JY, Daviet L, Dzau VJ, Horiuchi M. Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. J Clin Invest 1999;103:63-71.
23. Bagby SP, LeBard LS, Luo Z, Ogden BE, Corless C, McPherson ED, et al. ANG II AT(1) and AT(2) receptors in developing kidney of normal microswine. Am J Physiol Renal Physiol 2002;283:F755-764.
24. Gendron L, Payet MD, Gallo-Payet N. The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms. J Mol Endocrinol 2003;31:359-72.
25. Peters B, Clausmeyer S, Teubner P, Obermuller N, Kranzlin B, Gretz N, et al. Changes of AT(2) receptor levels in the rat adrenal cortex and medulla induced by bilateral nephrectomy and its modulation by circulating ANG ii. J Histochem Cytochem 2001;49: 649-56.
26. Yamada H, Akishita M, Ito M, Tamura K, Daviet L, Lehtonen JY, et al. AT2 receptor and vascular smooth muscle cell differentiation in vascular development. Hypertension 1999;33:1414-9.
27. Janke J, Engeli S, Gorzelniak K, Luft FC, Sharma AM. Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors. Diabetes 2002;51:1699-707.
28. Schoof E, Girstl M, Frobenius W, Kirschbaum M, Dorr HG, Rascher W, et al. Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia. J Clin Endocrinol Metab 2001;86:1313-7.
29. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative pcr and the 2(-Delta Delta C(T)) method. Methods 2001;25: 402-8.
30. Park JS, Kim HY, Kim HW, Chae GN, Oh HT, Park JY, et al. Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells. Mech Ageing Dev 2005;126:551-9.
31. Mintz GS, Pichard AD, Popma JJ, Kent KM, Satler LF, Bucher TA, et al. Determinants and correlates of target lesion calcium in coronary artery disease: a clinical, angiographic and intravascular ultrasound study. J Am Coll Cardiol 1997;29:268-74.
32. Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA, et al. Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol 1998; 31:126-33.
33. Querques F, Cantilena B, Cozzolino C, Esposito MT, Passaro F, Parisi S, et al. Angiotensin receptor I stimulates osteoprogenitor proliferation through tgfbetamediated signaling. J Cell Physiol 2015;230:1466-74.
34. Wagenaar GT, Sengers RM, Laghmani el H, Chen X, Lindeboom MP, Roks AJ, et al. Angiotensin II type 2 receptor ligand pd123319 attenuates hyperoxiainduced lung and heart injury at a low dose in newborn rats. Am J Physiol Lung Cell Mol Physiol 2014;307: L261-72.
35. Etelvino GM, Peluso AA, Santos RA. New components of the renin-angiotensin system: alamandine and the mas-related g protein-coupled receptor D. Curr Hypertens Rep 2014;16:433.