Sex differences in dose escalation and overdose death during chronic opioid therapy: A population-based cohort study

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Kaplovitch, Eric ^a   Gomes, Tara ^b,c   Camacho, Ximena ^b   Dhalla, Irfan A ^a,b   Mamdani, Muhammad M ^b,c   Juurlink, David N ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

OPIATE; NARCOTIC ANALGESIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CANADA; CANCER PAIN; CAUSE OF DEATH; CHRONIC NONCANCER PAIN; CHRONIC PAIN; COHORT ANALYSIS; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG MEGADOSE; DRUG OVERDOSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONCANCER PAIN; PRESCRIPTION; RISK ASSESSMENT; SEX DIFFERENCE; TREATMENT DURATION; TREATMENT OUTCOME; CHRONIC DISEASE; DEATH; MIDDLE AGED; MORTALITY; ONTARIO; OPIOID-RELATED DISORDERS; PAIN; RISK FACTOR;

ADULT; ANALGESICS, OPIOID; CHRONIC DISEASE; COHORT STUDIES; DEATH; DRUG OVERDOSE; FEMALE; HUMANS; MALE; MIDDLE AGED; ONTARIO; OPIOID-RELATED DISORDERS; PAIN; RISK FACTORS; SEX FACTORS;

EID: 84942843871     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134550     Document Type: Article

References (40)

1. Gomes T, Juurlink DN, Dhalla IA, Mailis-Gagnon A, Paterson JM, Mamdani MM. Trends in opioid use and dosing among socio-economically disadvantaged patients. Open Med 2011;5:e13-e22. PMID: 22046214
2. Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs.2000. Pain 2004;109:514-9. PMID: 15157714
3. Sullivan MD, Edlund MJ, Fan MY, Devries A, Brennan Braden J, Martin BC. Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and medicaid insurance plans: The TROUP study. Pain 2008;138:440-9. doi: 10.1016/j.pain. 2008.04.027 PMID: 18547726
4. Boudreau D, Von Korff M, Rutter CM, Saunders K, Ray GT, Sullivan MD, et al. Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf 2009;18:1166-75. doi: 10. 1002/pds.1833 PMID: 19718704
5. Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009;10:113-30. doi: 10.1016/j.jpain. 2008. 10.008 PMID: 19187889
6. Portenoy RK, Foley KM. Chronic use of opioid analgesics in non-malignant pain: report of 38 cases. Pain 1986;25:171-86. PMID: 2873550
7. Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN. Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. CMAJ 2009;181:891-6. doi: 10.1503/cmaj.090784 PMID: 19969578
8. Centers for Disease Control and Prevention (CDC). Vital signs: Overdoses of prescription opioid pain relievers-united states, 1999-2008. MMWR Morb Mortal Wkly Rep. 2011;60:1487-92. PMID: 22048730
9. Warner M, Chen LH, Makuc DM, Anderson RN, Minino AM. Drug poisoning deaths in the united states, 1980-2008. NCHS Data Brief 2011;81:1-8. PMID: 22617462
10. Dhalla IA, Persaud N, Juurlink DN. Facing up to the prescription opioid crisis. BMJ 2011;343:d5142. doi: 10.1136/bmj.d5142 PMID: 21862533
11. Von KM, Kolodny A, Deyo RA, Chou R. Long-term opioid therapy reconsidered. Ann Intern Med 2011;155:325-8. doi: 10.7326/0003-4819-155-5-201109060-00011 PMID: 21893626
12. Nelson LS, Perrone J. Curbing the opioid epidemic in the United States: the risk evaluation and mitigation strategy (REMS). JAMA 2012;308:457-8. doi: 10.1001/jama.2012.8165 PMID: 22851109
13. National Opioid Use Guideline Group (NOUGG). Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain. 2010 Available: http://nationalpaincentre.mcmaster.ca/opioid/. Accessed 28 July 2013.
14. Chou R, Ballantyne JC, Fanciullo GJ, Fine PG, Miaskowski C. Research gaps on use of opioids for chronic noncancer pain: findings from a review of the evidence for an American Pain Society and American Academy of Pain Medicine clinical practice guideline. J Pain 2009;10:147-59. doi: 10.1016/j. jpain. 2008.10.007 PMID: 19187891
15. Wisniewski AM, Purdy CH, Blondell RD. The epidemiologic association between opioid prescribing, non-medical use, and emergency department visits. J Addict Dis 2008;27:1-11.
16. Joynt M, Train MK, Robbins BW, Halterman JS, Caiola E, Fortuna RJ. The Impact of Neighborhood Socioeconomic Status and Race on the Prescribing of Opioids in Emergency Departments Throughout the United States. J Gen Intern Med 2013. Epub ahead of print 2013 June 25.
17. Pletcher MJ, Kertesz SG, Kohn MA, Gonzales R. Trends in opioid prescribing by race/ethnicity for patients seeking care in US emergency departments. JAMA 2008 2; 299:70-8. doi: 10.1001/jama. 2007.64 PMID: 18167408
18. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 2009;10:447-85. doi: 10.1016/j.jpain. 2008. 12.001 PMID: 19411059
19. Back SE, Payne RL, Simpson AN, Brady KT. Gender and prescription opioids: findings from the National Survey on Drug Use and Health. Addict Behav 2010;35:1001-7. doi: 10.1016/j.addbeh.2010. 06.018 PMID: 20598809
20. Green CR, Wheeler JR, La Porte F. Clinical decision making in pain management: Contributions of physician and patient characteristics to variations in practice. J Pain 2003;4:29-39. PMID: 14622725
21. Sadowski CA, Carrie AG, Grymonpre RE, Metge CJ, St John P. Access and intensity of use of prescription analgesics among older Manitobans. Can J Clin Pharmacol 2009;16:e322-e330. PMID: 19483264
22. Campbell CI, Weisner C, Leresche L, Ray GT, Saunders K, Sullivan MD, et al. Age and gender trends in long-term opioid analgesic use for noncancer pain. Am J Public Health 2010;100:2541-7. doi: 10. 2105/AJPH.2009.180646 PMID: 20724688
23. Han H, Kass PH, Wilsey BL, Li CS. Age, gender, and earlier opioid requirement associations with the rate of dose escalation in long-term opioid therapy. J. Opioid Manag 2013;9:129-38 doi: 10.5055/jom. 2012.0154 PMID: 23709322
24. Levy AR, O'Brien BJ, Sellors C, Grootendorst P, Willison D. Coding accuracy of administrative drug claims in the Ontario Drug Benefit database. Can J Clin Pharmacol 2003;10:67-71. PMID: 12879144
25. Hall S, Schulze K, Groome P, Mackillop W, Holowaty E. Using cancer registry data for survival studies: the example of the Ontario Cancer Registry. J Clin Epidemiol 2006;59:67-76. PMID: 16360563
26. Hux JE, Ivis F, Flintoft V, Bica A. Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm. Diabetes Care 2002;25:512-6. PMID: 11874939
27. Gomes T, Mamdani MM, Dhalla IA, Paterson JM, Juurlink D. N. Opioid dose and drug-related mortality in patients with nonmalignant pain. Arch Intern Med 2011;171:686-91. doi: 10.1001/archinternmed. 2011.117 PMID: 21482846
28. Gomes T, Redelmeier DA, Juurlink DN, Dhalla IA, Camacho X, Mamdani MM. Opioid dose and risk of road trauma in Canada: a population-based study. JAMA Intern Med 2013;173:196-201. doi: 10.1001/2013.jamainternmed.733 PMID: 23318919
29. Mamdani M, Sykora K, Li P, Normand SL, Streiner DL, Austin PC, et al. Reader's guide to critical appraisal of cohort studies: 2. Assessing potential for confounding. BMJ 2005 23; 330:960-2. PMID: 15845982
30. Charlson ME, Pompei P, Ales KL, Mac Kenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-83. PMID: 3558716
31. IMS Institute for Healthcare Informatics. The Use of Medicines in the United States: Review of 2011. Available: http://www.imshealth.com/ims/Global/Content/Insights/IMS%20Institute%20for% 20Healthcare%20Informatics/IHII Medicines in U. S Report 2011.pdf. Accessed 28 July 2013.
32. Noble M, Tregear SJ, Treadwell JR, Schoelles K. Long-term opioid therapy for chronic noncancer pain: a systematic review and meta-analysis of efficacy and safety. J Pain Symptom Manage 2008;35:214-8. doi: 10.1016/j.jpainsymman. 2007.03.015 PMID: 18178367
33. Kissin I. Long-term opioid treatment of chronic nonmalignant pain: unproven efficacy and neglected safety? J Pain Res 2013;6:513-29. doi: 10.2147/JPR. S47182 PMID: 23874119
34. Furlan AD, Sandoval JA, Mailis-Gagnon A, Tunks E. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ 2006;174:1589-94. PMID: 16717269
35. Spiller H, Lorenz DJ, Bailey EJ, Dart RC. Epidemiological trends in abuse and misuse of prescription opioids. J Addict Dis 2009;28:130-6. doi: 10.1080/10550880902772431 PMID: 19340675
36. Jamison RN, Butler SF, Budman SH, Edwards RR, Wasan AD. Gender differences in risk factors for aberrant prescription opioid use. J Pain 2010;11:312-20. doi: 10.1016/j.jpain. 2009.07.016 PMID: 19944648
37. Back SE, Payne RA, Waldrop AE, Smith A, Reeves S, Brady KT. Prescription opioid aberrant behaviors: a pilot study of sex differences. Clin J Pain 2009;25:477-84. doi: 10.1097/AJP. 0b013e31819c2c2f PMID: 19542794
38. Moride Y, Abenhaim L. Evidence of the depletion of susceptibles effect in non-experimental pharmacoepidemiologic research. J Clin Epidemiol 1994;47:731-7. PMID: 7722586
39. Hall AJ, Logan JE, Toblin RL, Kaplan JA, Kraner JC, Bixler D, et al. Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA 2008;300:2613-20. doi: 10.1001/jama.2008.802 PMID: 19066381
40. Centers for Disease Control and Prevention (CDC). Vital Signs: Riskfor Overdose from Methadone Used for Pain Relief-United States, 1999-2010. MMWR Morb Mortal Wkly Rep. 2012;61:493-497. PMID: 22763888