Serum dehydroepiandrosterone sulfate and incident depression in the elderly: The Pro.V.A. study

American Journal of Geriatric Psychiatry

Volumn 23, Issue 8, 2015, Pages 863-871

  Veronese, Nicola ^a   De Rui, Marina ^a   Bolzetta, Francesco ^a   Zambon, Sabina ^a,b   Corti, Maria Chiara ^c   Baggio, Giovannella ^d   Toffanello, Elena Debora ^a   Crepaldi, Gaetano ^b   Perissinotto, Egle ^a   Manzato, Enzo ^a,b   Sergi, Giuseppe ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b CNR   (Italy)

^c Azienda Unit Locale Socio Sanitaria (ULSS) 16   (Italy)

^d UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

Depression; Elderly; Serum DHEAS

Indexed keywords

PRASTERONE SULFATE;

AGED; ARTICLE; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; GERIATRIC DEPRESSION SCALE; GERONTOPSYCHIATRY; HEARING IMPAIRMENT; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; SEX DIFFERENCE; BLOOD; DEMOGRAPHY; PROPORTIONAL HAZARDS MODEL; PSYCHOLOGICAL RATING SCALE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DEHYDROEPIANDROSTERONE SULFATE; DEPRESSION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; PROPORTIONAL HAZARDS MODELS; PSYCHIATRIC STATUS RATING SCALES; RESIDENCE CHARACTERISTICS; SEX FACTORS;

EID: 84942798412     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2014.10.009     Document Type: Article

References (39)

1. Djernes JK: Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand 2006; 113: 372-387
2. Rodda J, Walker Z, Carter J: Depression in older adults. BMJ 2011; 343:d5219
3. Orentreich N, Brind JL, Vogelman JH, et al: Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab 1992; 75:1002-1004
4. Guazzo EP, Kirkpatrick PJ, Goodyer IM, et al: Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age. J Clin Endocrinol Metab 1996; 81:3951-3960
5. Mazat L, Lafont S, Berr C, et al: Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci USA 2001; 98:8145-8150
6. Urani A, Roman FJ, Phan VL, et al: The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test. J Pharmacol Exp Ther 2001; 298:1269-1279
7. Majewska MD, Demirgören S, Spivak CE, et al: The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor. Brain Res 1990; 526:143-146
8. van Broekhoven F, Verkes RJ: Neurosteroids in depression: a review. Psychopharmacology 2003; 165:97-110
9. Kulkarni SK, Dhir A: s-1 receptors in major depression and anxiety. Expert Rev Neurother 2009; 9:1021-1034
10. Kinouchi K, Maeda S, Saito K, et al: Effects of d-and l-pentazocine on the release and uptake of norepinephrine in rat brain cortex. Res Commun Chem Pathol Pharmacol 1989; 63:201-213
11. Monnet FP, Mahe V, Robel P, et al: Neurosteroids, via s receptors, modulate the [3H]norepinephrine release evoked by N-methyl-Daspartate in the rat hippocampus. Proc Natl Acad Sci USA 1995; 92:3774-3778
12. Naert G, Maurice T, Tapia-Arancibia L, et al: Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats. Psychoneuroendocrinology 2007; 32:1062-1078
13. Berr C, Lafont S, Debuire B, et al: Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French communitybased study. Proc Natl Acad Sci USA 1996; 93:13410-13415
14. Barrett-Connor E, von Muhlen D, Laughlin GA, et al: Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo study. J Am Geriatr Soc 1999; 47:685-691
15. Morsink LF, Vogelzangs N, Nicklas BJ, et al: Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: results from the Health ABC study. Psychoneuroendocrinology 2007; 32:874-883
16. T'Sjoen GG, De Vos S, Goemaere S, et al: Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly men. J Am Geriatr Soc 2005; 53:636-642
17. Erdincler D, Bugay G, Ertan T, et al: Depression and sex hormones in elderly women. Arch Gerontol Geriatr 2004; 39:239-244
18. Goldman N, Glei DA: Sex differences in the relationship between DHEAS and health. Exp Gerontol 2007; 42:979-987
19. Yaffe K, Ettinger B, Pressman A, et al: Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study. Biol Psychiatry 1998; 43:694-700
20. Michikawa T, Nishiwaki Y, Nakano M, et al: Higher serum dehydroepiandrosterone sulfate levels are protectively associated with depressive symptoms in men, but not in women: a community-based cohort study of older Japanese. Am J Geriatr Psychiatry 2013; 21:1154-1163
21. Manthorpe J, Iliffe S: Suicide in later life: public health and practitioner perspectives. Int J Geriatr Psychiatry 2010; 25:1230-1238
22. Corti MC, Guralnik JM, Sartori L, et al: The effect of cardiovascular and osteoarticular diseases on disability in older Italian men and women: rationale, design, and sample characteristics of the Progetto Veneto Anziani (PRO.V.A.) study. J Am Geriatr Soc 2002; 50:1535-1540
23. Burke WJ, Houston MJ, Boust SJ, et al: Use of the Geriatric Depression Scale in dementia of the Alzheimer type. J Am Geriatr Soc 1989; 37:856-860
24. Katz S, Downs TD, Cash HR, et al: Progress in development of the index of ADL. Gerontologist 1970; 10:20-30
25. Guralnik JM, Simonsick EM, Ferrucci L, et al: A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994; 49:M85-M94
26. Fried LP, Tangen CM, Walston J, et al: Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-M156
27. Solfrizzi V, Scafato E, Frisardi V, et al: Frailty syndrome and the risk of vascular dementia: The Italian longitudinal study on aging. Alzheim Dement 2013; 9:113-122
28. Kroboth PD, Salek FS, Pittenger AL, et al: DHEA and DHEA-S: a review. J Clin Pharmacol 1999; 39:327-348
29. Yesavage JA, Brink TL, Rose TL, et al: Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1982-83; 17:37-49
30. Fukai S, Akishita M, Yamada S, et al: Association of plasma sex hormone levels with functional decline in elderly men and women. Geriatr Gerontol Int 2009; 9:282-289
31. Haren MT, Malmstrom TK, Banks WA, et al: Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women. Maturitas 2007; 57:347-360
32. Alexopoulos GS, Bruce ML, Hull J, et al: Clinical determinants of suicidal ideation and behavior in geriatric depression. Arch Gen Psychiatry 1999; 56:1048-1053
33. Nett ST, Jorge-Rivera JC, Myers M, et al: Properties and sexspecific differences of GABAA receptors in neurons expressing gamma1 subunit mRNA in the preoptic area of the rat. J Neurophysiol 1999; 81:192-203
34. Abadie JM, Wright B, Correa G, et al: Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program. Diabetes 1993; 42:662-669
35. Li CM, Zhang X, Hoffman HJ, et al: Hearing impairment associated with depression in US adults, National Health and Nutrition Examination Survey 2005-2010. JAMA Otolaryngol Head Neck Surg 2014; 140:293-302
36. Lohman M, Dumenci L, Mezuk B: Sex differences in the construct overlap of frailty and depression: evidence from the Health and Retirement Study. J Am Geriatr Soc 2014; 62:500-505
37. Toffanello ED, Sergi G, Veronese N, et al: Serum 25-hydroxyvitamin D and the onset of late-life depressive mood in older men and women: the Pro.V.A. study. J Gerontol A Biol Sci Med Sci 2014; 69:1554-1561
38. Cappola AR, O'Meara ES, Guo W, et al: Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol A Biol Sci Med Sci 2009; 64:1268-1274
39. Goodyer IM, Park RJ, Netherton CM, et al: Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology. Br J Psychiatry 2001; 179:243-249