메뉴 건너뛰기




Volumn 100, Issue 7, 2015, Pages 2724-2733

Hydrogen activates atp-binding cassette transporter a1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: A double-blinded, randomized, and placebo-controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN B100; APOLIPOPROTEIN M; DRINKING WATER; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROGEN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PLACEBO; PRE BETA HIGH DENSITY LIPOPROTEIN; ABCA1 PROTEIN, HUMAN;

EID: 84942694147     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1321     Document Type: Article
Times cited : (42)

References (35)
  • 2
    • 3042606551 scopus 로고    scopus 로고
    • Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host
    • KhovidhunkitW,KimMS,MemonRA,et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res. 2004;45:1169-1196.
    • (2004) J Lipid Res , vol.45 , pp. 1169-1196
    • Khovidhunkit, W.1    Kim, M.S.2    Memon, R.A.3
  • 3
    • 12744263365 scopus 로고    scopus 로고
    • Dyslipidemia and inflammation: An evolutionary conserved mechanism
    • Esteve E, Ricart W, Fernández-Real JM. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr. 2005; 24:16-31.
    • (2005) Clin Nutr , vol.24 , pp. 16-31
    • Esteve, E.1    Ricart, W.2    Fernández-Real, J.M.3
  • 4
    • 38849140840 scopus 로고    scopus 로고
    • Is raising HDL a futile strategy for atheroprotection
    • Joy T, Hegele RA. Is raising HDL a futile strategy for atheroprotection? Nat Rev Drug Discov. 2008;7:143-155.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 143-155
    • Joy, T.1    Hegele, R.A.2
  • 5
    • 33846488058 scopus 로고    scopus 로고
    • Mechanisms of disease: HDL metabolism as a target for novel therapies
    • Rader DJ. Mechanisms of disease: HDL metabolism as a target for novel therapies. Nat Clin Pract Cardiovasc Med. 2007;4:102-109.
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. 102-109
    • Rader, D.J.1
  • 6
    • 34250021071 scopus 로고    scopus 로고
    • Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
    • Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13:688-694.
    • (2007) Nat Med , vol.13 , pp. 688-694
    • Ohsawa, I.1    Ishikawa, M.2    Takahashi, K.3
  • 7
    • 84872257429 scopus 로고    scopus 로고
    • Hydrogen improves glycemic control in type 1 diabetic animal model by promoting glucose uptake into skeletal muscle
    • Amitani H, Asakawa A, Cheng K, et al. Hydrogen improves glycemic control in type 1 diabetic animal model by promoting glucose uptake into skeletal muscle. PLoS One. 2013;8:e53913.
    • (2013) PLoS One , vol.8 , pp. e53913
    • Amitani, H.1    Asakawa, A.2    Cheng, K.3
  • 8
    • 41349120002 scopus 로고    scopus 로고
    • Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
    • Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008; 28:137-143.
    • (2008) Nutr Res , vol.28 , pp. 137-143
    • Kajiyama, S.1    Hasegawa, G.2    Asano, M.3
  • 9
    • 0034890442 scopus 로고    scopus 로고
    • Anti-inflammatory properties of molecular hydrogen: Investigation on parasite-induced liver inflammation
    • Gharib B, Hanna S, Abdallahi OM, Lepidi H, Gardette B, De Reggi M. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. CRAcad Sci III. 2001; 324:719-724.
    • (2001) CRAcad Sci III , vol.324 , pp. 719-724
    • Gharib, B.1    Hanna, S.2    Abdallahi, O.M.3    Lepidi, H.4    Gardette, B.5    De Reggi, M.6
  • 10
    • 84857033580 scopus 로고    scopus 로고
    • Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein e knockout mice
    • Song G, Tian H, Qin S, et al. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis. 2012;221:55-65.
    • (2012) Atherosclerosis , vol.221 , pp. 55-65
    • Song, G.1    Tian, H.2    Qin, S.3
  • 11
    • 84861574324 scopus 로고    scopus 로고
    • Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters
    • Zong C, Song G, Yao S, et al. Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism. 2012;61:794-800.
    • (2012) Metabolism , vol.61 , pp. 794-800
    • Zong, C.1    Song, G.2    Yao, S.3
  • 12
    • 84878976217 scopus 로고    scopus 로고
    • Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
    • Song G, Li M, Sang H, et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res. 2013;54:1884-1893.
    • (2013) J Lipid Res , vol.54 , pp. 1884-1893
    • Song, G.1    Li, M.2    Sang, H.3
  • 13
    • 33748681287 scopus 로고    scopus 로고
    • Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
    • Kontush A, Chapman MJ. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006;58:342-374.
    • (2006) Pharmacol Rev , vol.58 , pp. 342-374
    • Kontush, A.1    Chapman, M.J.2
  • 14
    • 0037126526 scopus 로고    scopus 로고
    • Third report of the national cholesterol education program (ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 17 2002;106: 3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 15
    • 0022487751 scopus 로고
    • Plasma lipoproteins. Part A: Preparation, structure, and molecular biology
    • Plasma lipoproteins. Part A: preparation, structure, and molecular biology. Methods Enzymol. 1986;128:1-992.
    • (1986) Methods Enzymol , vol.128 , pp. 1-992
  • 16
    • 84895525573 scopus 로고    scopus 로고
    • Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability
    • Yu Y, Guo S, Feng Y, et al. Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. Lipids. 2014;49:183-190.
    • (2014) Lipids , vol.49 , pp. 183-190
    • Yu, Y.1    Guo, S.2    Feng, Y.3
  • 17
    • 37349021003 scopus 로고    scopus 로고
    • Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
    • Tabas I, Williams KJ, Borén J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation. 2007;116:1832-1844.
    • (2007) Circulation , vol.116 , pp. 1832-1844
    • Tabas, I.1    Williams, K.J.2    Borén, J.3
  • 19
    • 80051795660 scopus 로고    scopus 로고
    • PLTP regulates STAT3 and NFB in differentiated THP1 cells and human monocyte-derived macrophages
    • Vuletic S, Dong W, Wolfbauer G, Tang C, Albers JJ. PLTP regulates STAT3 and NFB in differentiated THP1 cells and human monocyte-derived macrophages. Biochim Biophys Acta. 2011;1813: 1917-1924.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1917-1924
    • Vuletic, S.1    Dong, W.2    Wolfbauer, G.3    Tang, C.4    Albers, J.J.5
  • 20
    • 0031825004 scopus 로고    scopus 로고
    • Inhibitory effect of inducible type nitric oxide synthase on oxidative modification of low density lipoprotein by vascular smooth muscle cells
    • Rikitake Y, Hirata K, Kawashima S, Akita H, Yokoyama M. Inhibitory effect of inducible type nitric oxide synthase on oxidative modification of low density lipoprotein by vascular smooth muscle cells. Atherosclerosis. 1998;136:51-57.
    • (1998) Atherosclerosis , vol.136 , pp. 51-57
    • Rikitake, Y.1    Hirata, K.2    Kawashima, S.3    Akita, H.4    Yokoyama, M.5
  • 21
    • 0032902489 scopus 로고    scopus 로고
    • Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1
    • McCrohon JA, Jessup W, Handelsman DJ, Celermajer DS. Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation. 1999;99:2317-2322.
    • (1999) Circulation , vol.99 , pp. 2317-2322
    • McCrohon, J.A.1    Jessup, W.2    Handelsman, D.J.3    Celermajer, D.S.4
  • 22
    • 84903159932 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2): S49-S73.
    • (2014) Circulation , vol.129 , Issue.25 , pp. S49-S73
    • Goff, D.C.1    Lloyd-Jones, D.M.2    Bennett, G.3
  • 23
    • 0021811173 scopus 로고
    • Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility
    • Kunitake ST, La Sala KJ, Kane JP. Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility. J Lipid Res. 1985;26:549-555.
    • (1985) J Lipid Res , vol.26 , pp. 549-555
    • Kunitake, S.T.1    La Sala, K.J.2    Kane, J.P.3
  • 24
    • 0028287280 scopus 로고
    • Unique epitope of apolipoprotein A-I expressed in prebeta-1 high-density lipoprotein and its role in the catalyzed efflux of cellular cholesterol
    • Fielding PE, Kawano M, Catapano AL, Zoppo A, Marcovina S, Fielding CJ. Unique epitope of apolipoprotein A-I expressed in prebeta-1 high-density lipoprotein and its role in the catalyzed efflux of cellular cholesterol. Biochemistry. 1994;33:6981-6985.
    • (1994) Biochemistry , vol.33 , pp. 6981-6985
    • Fielding, P.E.1    Kawano, M.2    Catapano, A.L.3    Zoppo, A.4    Marcovina, S.5    Fielding, C.J.6
  • 25
    • 14444283888 scopus 로고    scopus 로고
    • Prebeta-1 HDL in plasma of normolipidemic individuals: Influences of plasma lipoproteins, age, and gender
    • O'Connor PM, Zysow BR, Schoenhaus SA, et al. Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender. J Lipid Res. 1998;39:670-678.
    • (1998) J Lipid Res , vol.39 , pp. 670-678
    • O'connor, P.M.1    Zysow, B.R.2    Schoenhaus, S.A.3
  • 27
    • 77954381444 scopus 로고    scopus 로고
    • High pre-1 HDL concentrations and low lecithin:cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol
    • Sethi AA, Sampson M, Warnick R, et al. High pre-1 HDL concentrations and low lecithin:cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol. Clin Chem. 2010;56:1128-1137.
    • (2010) Clin Chem , vol.56 , pp. 1128-1137
    • Sethi, A.A.1    Sampson, M.2    Warnick, R.3
  • 28
    • 0014264541 scopus 로고
    • The plasma lecithins:cholesterol acyltransferase reaction
    • Glomset JA. The plasma lecithins:cholesterol acyltransferase reaction. J Lipid Res. 1968;9:155-167.
    • (1968) J Lipid Res , vol.9 , pp. 155-167
    • Glomset, J.A.1
  • 29
    • 65249119467 scopus 로고    scopus 로고
    • Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase
    • Nijstad N, Wiersma H, Gautier T, van der Giet M, Maugeais C, Tietge UJ. Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase. J Biol Chem. 2009;284:6093-6100.
    • (2009) J Biol Chem , vol.284 , pp. 6093-6100
    • Nijstad, N.1    Wiersma, H.2    Gautier, T.3    Van Der Giet, M.4    Maugeais, C.5    Tietge, U.J.6
  • 31
    • 17644393111 scopus 로고    scopus 로고
    • Apolipoprotein M is required for pre-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
    • Wolfrum C, Poy MN, Stoffel M. Apolipoprotein M is required for pre-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med. 2005;11:418-422.
    • (2005) Nat Med , vol.11 , pp. 418-422
    • Wolfrum, C.1    Poy, M.N.2    Stoffel, M.3
  • 35
    • 1842815777 scopus 로고    scopus 로고
    • Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    • Brousseau ME, Schaefer EJ, Wolfe ML, et al. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004;350:1505-1515.
    • (2004) N Engl J Med , vol.350 , pp. 1505-1515
    • Brousseau, M.E.1    Schaefer, E.J.2    Wolfe, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.