Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Qu, Dongfeng ^a,b,c   Weygant, Nathaniel ^a   May, Randal ^a,b   Chandrakesan, Parthasarathy ^a,c   Madhoun, Mohammad ^a   Ali, Naushad ^a,c   Sureban, Sripathi M ^a,b,c   An, Guangyu ^d   Schlosser, Michael J ^e   Houchen, Courtney W ^a,b,c,e  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Peggy and Charles Stephenson Oklahoma Cancer Institute   (United States)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e COARE Biotechnology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLECORTIN LIKE KINASE 1; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; DCAMKL1 PROTEIN, MOUSE; DEXTRAN SULFATE; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PROTEIN DEPLETION; ANIMAL; APOPTOSIS; CELL PROLIFERATION; CHEMICALLY INDUCED; COLON; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENE DELETION; GENETICS; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; STEM CELL;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; COLITIS; COLON; DEXTRAN SULFATE; GENE DELETION; INTESTINAL MUCOSA; MALE; MICE; PROTEIN-SERINE-THREONINE KINASES; STEM CELLS;

EID: 84942693515     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134212     Document Type: Article

References (22)

1. Kaser A, Zeissig S, Blumberg RS Inflammatory bowel disease. Annu Rev Immunol. 2010; 28: 573-621. doi: 10.1146/annurev-immunol-030409-101225 PMID: 20192811
2. Xavier RJ, Podolsky DK Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007; 448: 427-434. PMID: 17653185
3. Khor B, Gardet A, Xavier RJ Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011; 474: 307-317. doi: 10.1038/nature10209 PMID: 21677747
4. Koch S, Nusrat A The life and death of epithelia during inflammation: lessons learned from the gut. Annu Rev Pathol. 2012; 7: 35-60. doi: 10.1146/annurev-pathol-011811-120905 PMID: 21838548
5. Koo BK, Clevers H Stem Cells Marked by the R-Spondin Receptor LGR5. Gastroenterology. 2014; 147: 289-302. doi: 10.1053/j.gastro.2014.05.007 PMID: 24859206
6. Gordon JI, Hermiston ML Differentiation and self-renewal in the mouse gastrointestinal epithelium. Curr Opin Cell Biol. 1994; 6: 795-803. PMID: 7880525
7. May R, Riehl TE, Hunt C, Sureban SM, Anant S, Houchen CW Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells. 2008; 26: 630-637. PMID: 18055444
8. May R, Sureban SM, Hoang N, Riehl TE, Lightfoot SA, Ramanujam R, et al. Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells. 2009; 27: 2571-2579. doi: 10.1002/stem.193 PMID: 19676123
9. Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, et al. Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet. 2012; 45: 98-103. doi: 10.1038/ng.2481 PMID: 23202126
10. Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, et al. Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest. 2014.
11. May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, et al. Brief report: dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury. Stem Cells. 2014; 32: 822-827. doi: 10. 1002/stem.1566 PMID: 24123696
12. Kim ER, Chang DK Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis. World J Gastroenterol. 2014; 20: 9872-9881. doi: 10.3748/wjg.v20.i29.9872 PMID: 25110418
13. Grisham MB, Hernandez LA, Granger DN Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol. 1986; 251: G567-574. PMID: 3020994
14. Madison BB, Dunbar L, Qiao XT, Braunstein K, Braunstein E, Gumucio DL Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem. 2002; 277: 33275-33283. PMID: 12065599
15. Hering NA, Fromm M, Schulzke JD Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J Physiol. 2012; 590: 1035-1044. doi: 10.1113/jphysiol.2011.224568 PMID: 22219336
16. Perse M, Cerar A Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol. 2012; 2012: 718617. doi: 10.1155/2012/718617 PMID: 22665990
17. Dignass AU, Baumgart DC, Sturm A Review article: the aetiopathogenesis of inflammatory bowel disease-immunology and repair mechanisms. Aliment Pharmacol Ther. 2004; 20 Suppl 4: 9-17. PMID: 15352888
18. Clayburgh DR, Shen L, Turner JR A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest. 2004; 84: 282-291. PMID: 14767487
19. Koelink PJ, Overbeek SA, Braber S, Morgan ME, Henricks PA, Abdul Roda M, et al. Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Gut. 2014; 63: 578-587. doi: 10.1136/gutjnl-2012-303252 PMID: 23525573
20. Wallace JL COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation. Scientific-WorldJournal. 2006; 6: 577-588. PMID: 16752007
21. Atreya I, Atreya R, Neurath MF NF-kappaB in inflammatory bowel disease. J Intern Med. 2008; 263: 591-596. doi: 10.1111/j.1365-2796.2008.01953.x PMID: 18479258
22. Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, et al. Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2014; 306: G404-411. doi: 10.1152/ajpgi.00088.2013 PMID: 24368703