Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG)

Journal of Pharmacological and Toxicological Methods

Volumn 75, Issue , 2015, Pages 135-142

  Metea, Monica ^a   Litwak, Mona ^b   Arezzo, Joseph ^b  

^a Smithers Viscient   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Convulsions; EEG spectral analysis; Electromyography EMG; Preclinical seizure risk assessment; Premonitory signs; Regulatory drug development; Safety pharmacology; Seizure; Sharp waves; Telemetry; Tremors; Video EEG

Indexed keywords

ARTICLE; CLINICAL ASSESSMENT; ELECTROENCEPHALOGRAM; ELECTROMYOGRAPHY; EXPERIMENTAL MODEL; HIGH FREQUENCY OSCILLATION; HUMAN; MATHEMATICAL COMPUTING; NONHUMAN; RISK ASSESSMENT; RISK FACTOR; SEIZURE; SLEEP SPINDLE; SLEEP WAKING CYCLE; SPIKE WAVE; TEMPORAL LOBE EPILEPSY; ANIMAL; CHEMICALLY INDUCED; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ELECTROENCEPHALOGRAPHY; PATHOPHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; SEIZURES; TELEMETRY;

ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ELECTROENCEPHALOGRAPHY; HUMANS; SEIZURES; TELEMETRY;

EID: 84942551022     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2015.04.001     Document Type: Article

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