Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Aging Male

Volumn 18, Issue 3, 2015, Pages 175-179

  Chin, Kok Yong ^a   Ima Nirwana, Soelaiman ^a   Wan Ngah, Wan Zurinah ^a  

^a DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Men; sex hormone binding globulin; testosterone; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGE; ARTICLE; BODY MASS; CHINESE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; ETHNICITY; HUMAN; MAJOR CLINICAL STUDY; MALAY (PEOPLE); MALAYSIA; MALAYSIAN; MALE; NORMAL VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL; TREND STUDY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; MIDDLE AGED; REGRESSION ANALYSIS;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CROSS-SECTIONAL STUDIES; HUMANS; MALAYSIA; MALE; MIDDLE AGED; REGRESSION ANALYSIS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; VITAMIN D;

EID: 84942520694     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2015.1034686     Document Type: Article

References (33)

1. Holick MF. Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets 2011; 12: 4-18.
2. Wranicz J, Szostak-Wegierek D. Health outcomes of vitamin D. Part I. Characteristics and classic role. Rocz Panstw Zakl Hig 2014; 65: 179-84.
3. Alshahrani F, Aljohani N. Vitamin D: deficiency, sufficiency and toxicity. Nutrients 2013; 5: 3605-16.
4. Morris HA. Vitamin D activities for health outcomes. Ann Lab Med 2014; 34: 181-6.
5. Wang S. Epidemiology of vitamin D in health and disease. Nutr Res Rev 2009; 22: 188-203.
6. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc 2011; 86: 50-60.
7. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 2014; 21: 319-29.
8. Dimitrov V, Salehi-Tabar R, An BS, White JH. Non-classical mechanisms of transcriptional regulation by the vitamin D receptor: insights into calcium homeostasis, immune system regulation and cancer chemoprevention. J Steroid Biochem Mol Biol 2014; 144: 74-80.
9. Blomberg Jensen M, Nielsen JE, Jorgensen A, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod 2010; 25: 1303-11.
10. Kinuta K, Tanaka H, Moriwake T, et al. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000; 141: 1317-24.
11. Nimptsch K, Platz EA, Willett WC, Giovannucci E. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol (Oxf) 2012; 77: 106-12.
12. Wehr E, Pilz S, Boehm BO, et al. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf) 2010; 73: 243-8.
13. Chen RY, Nordin BE, Need AG, et al. Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males. Clin Endocrinol (Oxf) 2008; 69: 864-9.
14. Jorde R, Grimnes G, Hutchinson MS, et al. Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Horm Metab Res 2013; 45: 675-81.
15. Pilz S, Frisch S, Koertke H, et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 2011; 43: 223-5.
16. Chin KY, Ima-Nirwana S, Ibrahim S, et al. Vitamin D status in malaysian men and its associated factors. Nutrients 2014; 6: 5419-33.
17. Chin KY, Soelaiman IN, Mohamed IN, et al. Sex hormones in Malay and Chinese men in Malaysia: are there age and race differences? Clinics (Sao Paulo) 2013; 68: 159-66.
18. Chin KY, Soelaiman IN, Mohamed IN, et al. Discrepancy between the quantitative ultrasound value of Malaysian men and the manufacturer's reference and the impact on classification of bone health status. J Clin Densitom 2013; 16: 189-95.
19. Sodergard R, Backstrom T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982; 16: 801-10.
20. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-30.
21. Deurenberg P, Weststrate JA, Seidell JC. Body mass index as a measure of body fatness: age- and sex-specific prediction formulas. Br J Nutr 1991; 65: 105-14.
22. Fui MN, Dupuis P, Grossmann M. Lowered testosterone in male obesity: mechanisms, morbidity and management. Asian J Androl 2014; 16: 223-31.
23. Yassin DJ, Doros G, Hammerer PG, Yassin AA. Long-term testosterone treatment in elderly men with hypogonadism and erectile dysfunction reduces obesity parameters and improves metabolic syndrome and health-related quality of life. J Sex Med 2014; 11: 1567-76.
24. Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690-3.
25. Vimaleswaran KS, Berry DJ, Lu C, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013; 10: e1001383.
26. Lee DM, Tajar A, Pye SR, et al. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol 2012; 166: 77-85.
27. Hammoud AO, Meikle AW, Peterson CM, et al. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 2012; 14: 855-9.
28. Ramlau-Hansen CH, Moeller UK, Bonde JP, et al. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 2011; 95: 1000-4.
29. Lerchbaum E, Pilz S, Trummer C, et al. Serum vitamin D levels and hypogonadism in men. Andrology 2014; 2: 748-54.
30. Yeap BB. Testosterone and ill-health in aging men. Nat Clin Pract Endocrinol Metab 2009; 5: 113-21.
31. Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 2004; 350: 482-92.
32. Rosner W, Auchus RJ, Azziz R, et al. Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab 2007; 92: 405-13.
33. Snellman G, Melhus H, Gedeborg R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One 2010; 5: e11555