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Volumn 54, Issue 10, 2015, Pages 1027-1041

Clinical Pharmacokinetic, Pharmacodynamic, and Drug–Drug Interaction Profile of Canagliflozin, a Sodium-Glucose Co-transporter 2 Inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

CANAGLIFLOZIN; CYCLOSPORIN; GLIBENCLAMIDE; GLIBENCLAMIDE PLUS METFORMIN; GLUCOSE; GLUCURONOSYLTRANSFERASE; GLYCOSYLATED HEMOGLOBIN; HYDROCHLOROTHIAZIDE; ORAL CONTRACEPTIVE AGENT; PROBENECID; RIFAMPICIN; SIMVASTATIN; WARFARIN; ANTIDIABETIC AGENT; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 84942506312     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-015-0285-z     Document Type: Review
Times cited : (87)

References (59)
  • 1
    • 84871995815 scopus 로고    scopus 로고
    • Standards of medical care in diabetes—2015
    • American-Diabetes-Association. Standards of medical care in diabetes—2015. Diabetes Care. 2015; 38 Suppl 1: S11–66.
    • Diabetes Care. 2015; 38 Suppl , vol.1 , pp. S11-S66
  • 2
    • 84860220734 scopus 로고    scopus 로고
    • Poor achievement of guidelines-recommended targets in type 2 diabetes: findings from a contemporary prospective cohort study
    • COI: 1:STN:280:DC%2BC38vpvFynsQ%3D%3D, PID: 22452524
    • Braga MF, Casanova A, Teoh H, Gerstein HC, Fitchett DH, Honos G, et al. Poor achievement of guidelines-recommended targets in type 2 diabetes: findings from a contemporary prospective cohort study. Int J Clin Pract. 2012;66(5):457–64.
    • (2012) Int J Clin Pract , vol.66 , Issue.5 , pp. 457-464
    • Braga, M.F.1    Casanova, A.2    Teoh, H.3    Gerstein, H.C.4    Fitchett, D.H.5    Honos, G.6
  • 3
    • 84887064231 scopus 로고    scopus 로고
    • Optimal type 2 diabetes mellitus management: the randomised controlled OPTIMISE benchmarking study: baseline results from six European countries
    • PID: 22605788
    • Hermans MP, Brotons C, Elisaf M, Michel G, Muls E, Nobels F. Optimal type 2 diabetes mellitus management: the randomised controlled OPTIMISE benchmarking study: baseline results from six European countries. Eur J Prev Cardiol. 2013;20(6):1095–105.
    • (2013) Eur J Prev Cardiol , vol.20 , Issue.6 , pp. 1095-1105
    • Hermans, M.P.1    Brotons, C.2    Elisaf, M.3    Michel, G.4    Muls, E.5    Nobels, F.6
  • 4
    • 84861076878 scopus 로고    scopus 로고
    • Global cardiovascular disease risk assessment in United States adults with diabetes
    • PID: 22377485
    • Wong ND, Glovaci D, Wong K, Malik S, Franklin SS, Wygant G, et al. Global cardiovascular disease risk assessment in United States adults with diabetes. Diab Vasc Dis Res. 2012;9(2):146–52.
    • (2012) Diab Vasc Dis Res , vol.9 , Issue.2 , pp. 146-152
    • Wong, N.D.1    Glovaci, D.2    Wong, K.3    Malik, S.4    Franklin, S.S.5    Wygant, G.6
  • 5
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • COI: 1:CAS:528:DC%2BC3MXns1Cms7g%3D, PID: 21527736
    • Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011;91(2):733–94.
    • (2011) Physiol Rev , vol.91 , Issue.2 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 6
    • 84898898964 scopus 로고    scopus 로고
    • Drug-drug interactions with sodium-glucose cotransporters type 2 (SGLT2) inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXltFensLs%3D, PID: 24420910
    • Scheen AJ. Drug-drug interactions with sodium-glucose cotransporters type 2 (SGLT2) inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes mellitus. Clin Pharmacokinet. 2014;53(4):295–304.
    • (2014) Clin Pharmacokinet , vol.53 , Issue.4 , pp. 295-304
    • Scheen, A.J.1
  • 7
    • 77949429493 scopus 로고    scopus 로고
    • Renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for new anti-diabetic agent
    • COI: 1:CAS:528:DC%2BC3cXkvFKnsr4%3D, PID: 20180760
    • Nomura S. Renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for new anti-diabetic agent. Curr Top Med Chem. 2010;10(4):411–8.
    • (2010) Curr Top Med Chem , vol.10 , Issue.4 , pp. 411-418
    • Nomura, S.1
  • 8
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • COI: 1:CAS:528:DC%2BC38XjtFWitr0%3D, PID: 22355316
    • Liang Y, Arakawa K, Ueta K, Matsushita Y, Kuriyama C, Martin T, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3    Matsushita, Y.4    Kuriyama, C.5    Martin, T.6
  • 9
    • 41649087328 scopus 로고    scopus 로고
    • Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhvFWgtrY%3D, PID: 18260618
    • Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem. 2008;51(5):1145–9.
    • (2008) J Med Chem , vol.51 , Issue.5 , pp. 1145-1149
    • Meng, W.1    Ellsworth, B.A.2    Nirschl, A.A.3    McCann, P.J.4    Patel, M.5    Girotra, R.N.6
  • 10
    • 83655184724 scopus 로고    scopus 로고
    • Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
    • COI: 1:CAS:528:DC%2BC38XhvFOmsb8%3D, PID: 21985634
    • Grempler R, Thomas L, Eckhardt M, Himmelsbach F, Sauer A, Sharp DE, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012;14(1):83–90.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.1 , pp. 83-90
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3    Himmelsbach, F.4    Sauer, A.5    Sharp, D.E.6
  • 11
    • 84880320337 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXhs12gsLrJ, PID: 23670707
    • Devineni D, Curtin CR, Polidori D, Gutierrez MJ, Murphy J, Rusch S, et al. Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus. J Clin Pharmacol. 2013;53(6):601–10.
    • (2013) J Clin Pharmacol , vol.53 , Issue.6 , pp. 601-610
    • Devineni, D.1    Curtin, C.R.2    Polidori, D.3    Gutierrez, M.J.4    Murphy, J.5    Rusch, S.6
  • 12
    • 84961288553 scopus 로고    scopus 로고
    • Single- and multiple-dose pharmacokinetics and pharmacodynamics of canagliflozin, a selective inhibitor of sodium glucose co-transporter 2, in healthy participants
    • COI: 1:CAS:528:DC%2BC2MXmtlWgt70%3D, PID: 25500487
    • Devineni D, Vaccaro N, Polidori D, Stieltjes H, Wajs E. Single- and multiple-dose pharmacokinetics and pharmacodynamics of canagliflozin, a selective inhibitor of sodium glucose co-transporter 2, in healthy participants. Int J Clin Pharmacol Ther. 2015;53(2):129–38.
    • (2015) Int J Clin Pharmacol Ther , vol.53 , Issue.2 , pp. 129-138
    • Devineni, D.1    Vaccaro, N.2    Polidori, D.3    Stieltjes, H.4    Wajs, E.5
  • 13
    • 84929576870 scopus 로고    scopus 로고
    • Effect of canagliflozin on the pharmacokinetics of glyburide, metformin and simvastatin in healthy participants
    • Devineni D, Manitpisitkul P, Murphy J, Skee D, Wajs E, Mamidi RN, et al. Effect of canagliflozin on the pharmacokinetics of glyburide, metformin and simvastatin in healthy participants. Clin Pharm Drug Dev. 2014;. doi:10.1002/cpdd.166.
    • (2014) Clin Pharm Drug Dev
    • Devineni, D.1    Manitpisitkul, P.2    Murphy, J.3    Skee, D.4    Wajs, E.5    Mamidi, R.N.6
  • 14
    • 84963936051 scopus 로고    scopus 로고
    • Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on the pharmacokinetics of oral contraceptives, warfarin, and digoxin in healthy participants
    • COI: 1:CAS:528:DC%2BC2MXkt1ShsL8%3D, PID: 25345427
    • Devineni D, Manitpisitkul P, Vaccaro N, Bernard A, Skee D, MamidiRao N, et al. Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on the pharmacokinetics of oral contraceptives, warfarin, and digoxin in healthy participants. Int J Clin Pharmacol Ther. 2015;53(1):41–53.
    • (2015) Int J Clin Pharmacol Ther , vol.53 , Issue.1 , pp. 41-53
    • Devineni, D.1    Manitpisitkul, P.2    Vaccaro, N.3    Bernard, A.4    Skee, D.5    MamidiRao, N.6
  • 15
    • 84961290698 scopus 로고    scopus 로고
    • Effects of rifampin, cyclosporine A, or probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants
    • COI: 1:CAS:528:DC%2BC2MXmtlWgtL0%3D, PID: 25407255
    • Devineni D, Vaccaro N, Murphy J, Curtin C, MamidiRao N, Weiner S, et al. Effects of rifampin, cyclosporine A, or probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. Int J Clin Pharmacol Ther. 2015;53(2):115–28.
    • (2015) Int J Clin Pharmacol Ther , vol.53 , Issue.2 , pp. 115-128
    • Devineni, D.1    Vaccaro, N.2    Murphy, J.3    Curtin, C.4    MamidiRao, N.5    Weiner, S.6
  • 16
    • 84901472559 scopus 로고    scopus 로고
    • Effects of hydrochlorothiazide on the pharmacokinetics, pharmacodynamics, and tolerability of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants
    • COI: 1:CAS:528:DC%2BC2cXmtVCqsbs%3D, PID: 24726680
    • Devineni D, Vaccaro N, Polidori D, Rusch S, Wajs E. Effects of hydrochlorothiazide on the pharmacokinetics, pharmacodynamics, and tolerability of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. Clin Ther. 2014;36(5):698–710.
    • (2014) Clin Ther , vol.36 , Issue.5 , pp. 698-710
    • Devineni, D.1    Vaccaro, N.2    Polidori, D.3    Rusch, S.4    Wajs, E.5
  • 17
    • 84942503544 scopus 로고    scopus 로고
    • Wexler D, Vandebosch A, Usiskin K, Allison M, Devineni D. Study of electrocardiogram intervals in healthy adults receiving single oral doses of canagliflozin. Diabetes. 2010;59(1)
    • Wexler D, Vandebosch A, Usiskin K, Allison M, Devineni D. Study of electrocardiogram intervals in healthy adults receiving single oral doses of canagliflozin. Diabetes. 2010;59(1).
  • 18
    • 84939996168 scopus 로고    scopus 로고
    • Devineni D, Curtin CR, Marbury TC, Smith W, Vaccaro N, Wexler D, et al. Effect of hepatic or renal impairment on the pharmacokinetics of Canagliflozin, a sodium glucose co-transporter 2 inhibitor. Clin Ther. 2015;37(3):610–628.e4
    • Devineni D, Curtin CR, Marbury TC, Smith W, Vaccaro N, Wexler D, et al. Effect of hepatic or renal impairment on the pharmacokinetics of Canagliflozin, a sodium glucose co-transporter 2 inhibitor. Clin Ther. 2015;37(3):610–628.e4. doi:10.1016/j.clinthera.2014.12.013.
  • 19
    • 84936751014 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of once- and twice-daily multiple-doses of canagliflozin, a selective inhibitor of sodium glucose co-transporter 2, in healthy participants
    • Devineni D, Polidori, D, Curtin, CR, Murphy, J, Wang, SS, Stieltjes, H. Pharmacokinetics and pharmacodynamics of once- and twice-daily multiple-doses of canagliflozin, a selective inhibitor of sodium glucose co-transporter 2, in healthy participants. Int J Clin Pharmacol Ther. 2015. doi:10.5414/CP202324.
    • (2015) Int J Clin Pharmacol Ther
    • Devineni, D.1    Polidori, D.2    Curtin, C.R.3    Murphy, J.4    Wang, S.S.5    Stieltjes, H.6
  • 20
    • 84937023290 scopus 로고    scopus 로고
    • Absolute oral bioavailability and pharmacokinetics of canagliflozin: a microdose study in healthy participants
    • Devineni D, Murphy J, Wang S-S, Stieltjes H, Rothenberg P, Scheers E, et al. Absolute oral bioavailability and pharmacokinetics of canagliflozin: a microdose study in healthy participants. Clin Pharm Drug Dev. 2014;. doi:10.1002/cpdd.162.
    • (2014) Clin Pharm Drug Dev
    • Devineni, D.1    Murphy, J.2    Wang, S.-S.3    Stieltjes, H.4    Rothenberg, P.5    Scheers, E.6
  • 21
    • 84937022795 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, and assessment of dose proportionality in healthy participants
    • Devineni D, Manitpisitkul P, Murphy J, Stieltjes H, Ariyawansa J, Di Prospero N, et al. Effect of food on the pharmacokinetics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, and assessment of dose proportionality in healthy participants. Clin Pharm Drug Dev. 2014;. doi:10.1002/cpdd.151.
    • (2014) Clin Pharm Drug Dev
    • Devineni, D.1    Manitpisitkul, P.2    Murphy, J.3    Stieltjes, H.4    Ariyawansa, J.5    Di Prospero, N.6
  • 22
    • 84938525379 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of canagliflozin/metformin (150/1,000 mg) immediate-release fixed-dose combination tablet in healthy participants
    • COI: 1:CAS:528:DC%2BC2MXmtlWgs7k%3D, PID: 25546166
    • Murphy J, Wang SS, Stieltjes H, Wajs E, Devineni D. Effect of food on the pharmacokinetics of canagliflozin/metformin (150/1,000 mg) immediate-release fixed-dose combination tablet in healthy participants. Int J Clin Pharmacol Ther. 2015;53(3):256–64.
    • (2015) Int J Clin Pharmacol Ther , vol.53 , Issue.3 , pp. 256-264
    • Murphy, J.1    Wang, S.S.2    Stieltjes, H.3    Wajs, E.4    Devineni, D.5
  • 23
    • 84898821701 scopus 로고    scopus 로고
    • Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans
    • PID: 24568888
    • Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, et al. Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans. Drug Metab Dispos. 2014;42(5):903–16.
    • (2014) Drug Metab Dispos , vol.42 , Issue.5 , pp. 903-916
    • Mamidi, R.N.1    Cuyckens, F.2    Chen, J.3    Scheers, E.4    Kalamaridis, D.5    Lin, R.6
  • 24
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • COI: 1:STN:280:DyaK3szptFaqsg%3D%3D, PID: 8378254
    • Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res. 1993;10(7):1093–5.
    • (1993) Pharm Res , vol.10 , Issue.7 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 25
    • 84918559571 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers
    • COI: 1:CAS:528:DC%2BC2cXitFWiu7nJ, PID: 25424014
    • Kinoshita S, Kondo K. Evaluation of pharmacokinetic and pharmacodynamic interactions of canagliflozin and teneligliptin in Japanese healthy male volunteers. Expert Opin Drug Metab Toxicol. 2015;11(1):7–14.
    • (2015) Expert Opin Drug Metab Toxicol , vol.11 , Issue.1 , pp. 7-14
    • Kinoshita, S.1    Kondo, K.2
  • 26
    • 0029070091 scopus 로고
    • Glyburide protein binding and the effect of albumin glycation in children, young adults, and older adults with diabetes
    • COI: 1:STN:280:DyaK28%2FktVaksw%3D%3D, PID: 7560255
    • Olsen KM, Kearns GL, Kemp SF. Glyburide protein binding and the effect of albumin glycation in children, young adults, and older adults with diabetes. J Clin Pharmacol. 1995;35(7):739–45.
    • (1995) J Clin Pharmacol , vol.35 , Issue.7 , pp. 739-745
    • Olsen, K.M.1    Kearns, G.L.2    Kemp, S.F.3
  • 27
    • 0021271989 scopus 로고
    • Plasma protein binding of warfarin: methodological considerations
    • COI: 1:CAS:528:DyaL2cXks1Gmsbc%3D, PID: 6470938
    • Mungall D, Wong YY, Talbert RL, Crawford MH, Marshall J, Hawkins DW, et al. Plasma protein binding of warfarin: methodological considerations. J Pharm Sci. 1984;73(7):1000–1.
    • (1984) J Pharm Sci , vol.73 , Issue.7 , pp. 1000-1001
    • Mungall, D.1    Wong, Y.Y.2    Talbert, R.L.3    Crawford, M.H.4    Marshall, J.5    Hawkins, D.W.6
  • 28
    • 12244292690 scopus 로고    scopus 로고
    • Sanchez Navarro A, Garcia MJ, and Prous JR, Preclinical pharmacokinetics of statins
    • COI: 1:CAS:528:DC%2BD3sXht1SjtLo%3D, PID: 12616706
    • Reinoso RF. Sanchez Navarro A, Garcia MJ, and Prous JR, Preclinical pharmacokinetics of statins. Methods Find Exp Clin Pharmacol. 2002;24(9):593–613.
    • (2002) Methods Find Exp Clin Pharmacol , vol.24 , Issue.9 , pp. 593-613
    • Reinoso, R.F.1
  • 29
    • 6944221357 scopus 로고    scopus 로고
    • Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
    • COI: 1:CAS:528:DC%2BD2cXovFCktLg%3D, PID: 15304429
    • Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, et al. Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004;32(11):1201–8.
    • (2004) Drug Metab Dispos , vol.32 , Issue.11 , pp. 1201-1208
    • Williams, J.A.1    Hyland, R.2    Jones, B.C.3    Smith, D.A.4    Hurst, S.5    Goosen, T.C.6
  • 30
    • 84942501151 scopus 로고    scopus 로고
    • Hoeben E, Vermeulen A, Winter WD, Neyens M, Devineni D, Dunne A. Population pharmacokinetic analysis of canagliflozin, an orally active inhibitor of sodium-glucose co-transporter 2 for the treatment of patients with type 2 diabetes mellitus. Clin Pharmacokinet. 2015 (accepted for publications)
    • Hoeben E, Vermeulen A, Winter WD, Neyens M, Devineni D, Dunne A. Population pharmacokinetic analysis of canagliflozin, an orally active inhibitor of sodium-glucose co-transporter 2 for the treatment of patients with type 2 diabetes mellitus. Clin Pharmacokinet. 2015 (accepted for publications).
  • 31
    • 84919333505 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profiles of canagliflozin in Japanese patients with type 2 diabetes mellitus and moderate renal impairment
    • COI: 1:CAS:528:DC%2BC2cXhsFygurvF, PID: 25200141
    • Inagaki N, Kondo K, Yoshinari T, Ishii M, Sakai M, Kuki H, et al. Pharmacokinetic and pharmacodynamic profiles of canagliflozin in Japanese patients with type 2 diabetes mellitus and moderate renal impairment. Clin Drug Investig. 2014;34(10):731–42.
    • (2014) Clin Drug Investig , vol.34 , Issue.10 , pp. 731-742
    • Inagaki, N.1    Kondo, K.2    Yoshinari, T.3    Ishii, M.4    Sakai, M.5    Kuki, H.6
  • 32
    • 85010069718 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and safety of single-dose canagliflozin in healthy Chinese participants
    • Devineni D, Vaccaro N, Polidori D, Curtin CR, Stiltjes H, Hu P, et al. Pharmacokinetics, pharmacodynamics and safety of single-dose canagliflozin in healthy Chinese participants. Clin Ther. 2015 (accepted).
    • (2015) Clin Ther
    • Devineni, D.1    Vaccaro, N.2    Polidori, D.3    Curtin, C.R.4    Stiltjes, H.5    Hu, P.6
  • 33
    • 84877710926 scopus 로고    scopus 로고
    • Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus
    • PID: 23585665
    • Polidori D, Sha S, Ghosh A, Plum-Morschel L, Heise T, Rothenberg P. Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2013;98(5):E867–71.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.5 , pp. E867-E871
    • Polidori, D.1    Sha, S.2    Ghosh, A.3    Plum-Morschel, L.4    Heise, T.5    Rothenberg, P.6
  • 34
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • COI: 1:CAS:528:DC%2BC3MXoslaju7o%3D, PID: 21457428
    • Sha S, Devineni D, Ghosh A, Polidori D, Chien S, Wexler D, et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011;13(7):669–72.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.7 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3    Polidori, D.4    Chien, S.5    Wexler, D.6
  • 35
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • COI: 1:CAS:528:DC%2BC38XhtVSgsrrK, PID: 22226086
    • Devineni D, Morrow L, Hompesch M, Skee D, Vandebosch A, Murphy J, et al. Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab. 2012;14(6):539–45.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.6 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3    Skee, D.4    Vandebosch, A.5    Murphy, J.6
  • 36
    • 84919649970 scopus 로고    scopus 로고
    • Pharmacodynamic effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, from a randomized study in patients with type 2 diabetes
    • PID: 25166023
    • Sha S, Devineni D, Ghosh A, Polidori D, Hompesch M, Arnolds S, et al. Pharmacodynamic effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, from a randomized study in patients with type 2 diabetes. PLoS One. 2014;9(8):e105638.
    • (2014) PLoS One , vol.9 , Issue.8 , pp. e105638
    • Sha, S.1    Devineni, D.2    Ghosh, A.3    Polidori, D.4    Hompesch, M.5    Arnolds, S.6
  • 37
    • 84914154997 scopus 로고    scopus 로고
    • Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus
    • Sha S, Polidori D, Heise T, Natarajan J, Farrell K, Wang SS, et al. Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2014;16(11):1087–95. doi:10.1111/dom.12322.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.11 , pp. 1087-1095
    • Sha, S.1    Polidori, D.2    Heise, T.3    Natarajan, J.4    Farrell, K.5    Wang, S.S.6
  • 38
    • 84877865378 scopus 로고    scopus 로고
    • Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study
    • COI: 1:CAS:528:DC%2BC3sXhtlOrsrfN, PID: 23412078
    • Polidori D, Sha S, Mudaliar S, Ciaraldi TP, Ghosh A, Vaccaro N, et al. Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care. 2013;36(8):2154–61.
    • (2013) Diabetes Care , vol.36 , Issue.8 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3    Ciaraldi, T.P.4    Ghosh, A.5    Vaccaro, N.6
  • 39
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38Xps1Kit7k%3D, PID: 22492586
    • Rosenstock J, Aggarwal N, Polidori D, Zhao Y, Arbit D, Usiskin K, et al. Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care. 2012;35(6):1232–8.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3    Zhao, Y.4    Arbit, D.5    Usiskin, K.6
  • 40
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • COI: 1:STN:280:DC%2BC3s3lvVWlsQ%3D%3D, PID: 23279307
    • Stenlof K, Cefalu WT, Kim KA, Alba M, Usiskin K, Tong C, et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15(4):372–82.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.4 , pp. 372-382
    • Stenlof, K.1    Cefalu, W.T.2    Kim, K.A.3    Alba, M.4    Usiskin, K.5    Tong, C.6
  • 41
    • 84898600889 scopus 로고    scopus 로고
    • Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXjsVWqtbw%3D, PID: 24585202
    • Polidori D, Mari A, Ferrannini E. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes. Diabetologia. 2014;57(5):891–901.
    • (2014) Diabetologia , vol.57 , Issue.5 , pp. 891-901
    • Polidori, D.1    Mari, A.2    Ferrannini, E.3
  • 42
    • 84908259812 scopus 로고    scopus 로고
    • Canagliflozin, a sodium glucose co-transporter 2 inhibitor, reduces post-meal glucose excursion in patients with type 2 diabetes by a non-renal mechanism: results of a randomized trial
    • Stein P, Berg JK, Morrow L, Polidori D, Artis E, Rusch S, et al. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, reduces post-meal glucose excursion in patients with type 2 diabetes by a non-renal mechanism: results of a randomized trial. Metabolism. 2014;63(10):1296–303. doi:10.1016/j.metabol.2014.07.003.
    • (2014) Metabolism , vol.63 , Issue.10 , pp. 1296-1303
    • Stein, P.1    Berg, J.K.2    Morrow, L.3    Polidori, D.4    Artis, E.5    Rusch, S.6
  • 43
    • 0026033325 scopus 로고
    • Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression
    • COI: 1:CAS:528:DyaK3MXhtF2lsb4%3D, PID: 1991839
    • Kahn BB, Shulman GI, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest. 1991;87(2):561–70.
    • (1991) J Clin Invest , vol.87 , Issue.2 , pp. 561-570
    • Kahn, B.B.1    Shulman, G.I.2    DeFronzo, R.A.3    Cushman, S.W.4    Rossetti, L.5
  • 44
    • 0023571397 scopus 로고
    • Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
    • COI: 1:CAS:528:DyaL2sXmtlCiurY%3D, PID: 3308956
    • Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80(4):1037–44.
    • (1987) J Clin Invest , vol.80 , Issue.4 , pp. 1037-1044
    • Rossetti, L.1    Shulman, G.I.2    Zawalich, W.3    DeFronzo, R.A.4
  • 45
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • COI: 1:CAS:528:DyaL2sXktlOmsrg%3D, PID: 3571496
    • Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79(5):1510–5.
    • (1987) J Clin Invest , vol.79 , Issue.5 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3    Papachristou, D.4    DeFronzo, R.A.5
  • 46
    • 84888059660 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial
    • COI: 1:CAS:528:DC%2BC3sXhvVajtLnK, PID: 24118688
    • Wilding JP, Charpentier G, Hollander P, Gonzalez-Galvez G, Mathieu C, Vercruysse F, et al. Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial. Int J Clin Pract. 2013;67(12):1267–82.
    • (2013) Int J Clin Pract , vol.67 , Issue.12 , pp. 1267-1282
    • Wilding, J.P.1    Charpentier, G.2    Hollander, P.3    Gonzalez-Galvez, G.4    Mathieu, C.5    Vercruysse, F.6
  • 47
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • COI: 1:CAS:528:DC%2BC3sXhtFSls7fO, PID: 23850055
    • Cefalu WT, Leiter LA, Yoon KH, Arias P, Niskanen L, Xie J, et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet. 2013;382(9896):941–50.
    • (2013) Lancet , vol.382 , Issue.9896 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3    Arias, P.4    Niskanen, L.5    Xie, J.6
  • 48
    • 84940110139 scopus 로고    scopus 로고
    • Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study
    • COI: 1:CAS:528:DC%2BC2MXksFyksbk%3D, PID: 25205142
    • Leiter LA, Yoon KH, Arias P, Langslet G, Xie J, Balis DA, et al. Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study. Diabetes Care. 2015;38(3):355–64.
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 355-364
    • Leiter, L.A.1    Yoon, K.H.2    Arias, P.3    Langslet, G.4    Xie, J.5    Balis, D.A.6
  • 49
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial
    • COI: 1:CAS:528:DC%2BC3MXktFeht7Y%3D, PID: 21355967
    • Pratley R, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract. 2011;65(4):397–407.
    • (2011) Int J Clin Pract , vol.65 , Issue.4 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6
  • 50
    • 84899105421 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial
    • PID: 24595630
    • Perkins BA, Cherney DZ, Partridge H, Soleymanlou N, Tschirhart H, Zinman B, et al. Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial. Diabetes Care. 2014;37(5):1480–3.
    • (2014) Diabetes Care , vol.37 , Issue.5 , pp. 1480-1483
    • Perkins, B.A.1    Cherney, D.Z.2    Partridge, H.3    Soleymanlou, N.4    Tschirhart, H.5    Zinman, B.6
  • 51
    • 84864371186 scopus 로고    scopus 로고
    • Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats
    • COI: 1:CAS:528:DC%2BC38XhtFWntL3I
    • Devenny JJ, Godonis HE, Harvey SJ, Rooney S, Cullen MJ, Pelleymounter MA. Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. Obesity (Silver Spring). 2012;20(8):1645–52.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.8 , pp. 1645-1652
    • Devenny, J.J.1    Godonis, H.E.2    Harvey, S.J.3    Rooney, S.4    Cullen, M.J.5    Pelleymounter, M.A.6
  • 52
    • 84906924894 scopus 로고    scopus 로고
    • Safety and tolerability of canagliflozin in patients with type 2 diabetes mellitus: pooled analysis of phase 3 study results
    • PID: 24918789
    • Usiskin K, Kline I, Fung A, Mayer C, Meininger G. Safety and tolerability of canagliflozin in patients with type 2 diabetes mellitus: pooled analysis of phase 3 study results. Postgrad Med. 2014;126(3):16–34.
    • (2014) Postgrad Med , vol.126 , Issue.3 , pp. 16-34
    • Usiskin, K.1    Kline, I.2    Fung, A.3    Mayer, C.4    Meininger, G.5
  • 53
    • 84901830673 scopus 로고    scopus 로고
    • Canagliflozin: a review of its use in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXotFOqtLs%3D, PID: 24831734
    • Plosker G. Canagliflozin: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74(7):807–24.
    • (2014) Drugs , vol.74 , Issue.7 , pp. 807-824
    • Plosker, G.1
  • 54
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • PID: 25488697
    • Scheen AJ. Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs. 2015;75(1):33–59.
    • (2015) Drugs , vol.75 , Issue.1 , pp. 33-59
    • Scheen, A.J.1
  • 55
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial
    • COI: 1:CAS:528:DC%2BC2cXhtV2is7vI, PID: 23564919
    • Schernthaner G, Gross JL, Rosenstock J, Guarisco M, Fu M, Yee J, et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Diabetes Care. 2013;36(9):2508–15.
    • (2013) Diabetes Care , vol.36 , Issue.9 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3    Guarisco, M.4    Fu, M.5    Yee, J.6
  • 56
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial
    • COI: 1:CAS:528:DC%2BC3sXhsVOntrvO, PID: 24026211
    • Lavalle-Gonzalez FJ, Januszewicz A, Davidson J, Tong C, Qiu R, Canovatchel W, et al. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia. 2013;56(12):2582–92.
    • (2013) Diabetologia , vol.56 , Issue.12 , pp. 2582-2592
    • Lavalle-Gonzalez, F.J.1    Januszewicz, A.2    Davidson, J.3    Tong, C.4    Qiu, R.5    Canovatchel, W.6
  • 57
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • COI: 1:CAS:528:DC%2BC3sXlvVenu7c%3D, PID: 23464594
    • Yale JF, Bakris G, Cariou B, Yue D, David-Neto E, Xi L, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15(5):463–73.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.5 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3    Yue, D.4    David-Neto, E.5    Xi, L.6
  • 58
    • 84973343494 scopus 로고    scopus 로고
    • Reference ID: 3285059. Drugs@FDA: FDA Approved Drug Products
    • Invokana™, Prescribing Information, 2013. Reference ID: 3285059. Drugs@FDA: FDA Approved Drug Products. Original Approval Date March 29, 2013. http://www.accessdata.fda.gov. Accessed 13 Aug 2014.
    • (2013) Original Approval Date March , pp. 29
  • 59
    • 84919649970 scopus 로고    scopus 로고
    • Pharmacodynamic effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, from a randomized study in patients with type 2 diabetes
    • PID: 25166023
    • Sha S, Devineni D, Ghosh A, Polidori D, Hompesch M, Arnolds S, et al. Pharmacodynamic effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, from a randomized study in patients with type 2 diabetes. PLoS One. 2014;9(8):e105638.
    • (2014) PLoS One , vol.9 , Issue.8 , pp. e105638
    • Sha, S.1    Devineni, D.2    Ghosh, A.3    Polidori, D.4    Hompesch, M.5    Arnolds, S.6


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