Nano-scale treatment for amacro-scale disease: Nanoparticle-delivered siRNA silences CCR2 and treatsmyocarditis

European Heart Journal

Volumn 36, Issue 23, 2015, Pages 1434-1436

  Cooper, Leslie T ^a   Fairweather, DeLisa ^b,c  

^a MAYO CLINIC   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NANOCARRIER; SMALL INTERFERING RNA;

EDITORIAL; GENE SILENCING; HEART LEFT VENTRICLE FUNCTION; HUMAN; MYOCARDITIS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; T LYMPHOCYTE; TREATMENT RESPONSE; ANIMAL; AUTOIMMUNE DISEASES; FEMALE; GENETICS; MALE;

ANIMALS; AUTOIMMUNE DISEASES; CHEMOKINE CCL2; FEMALE; HUMANS; MALE; MYOCARDITIS; RNA, SMALL INTERFERING;

EID: 84942475068     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu302     Document Type: Editorial

References (16)

1. Schultheiss H-P, Kuhl U, Cooper LT. The management of myocarditis. Eur Heart J 2011;32:2616-2625.
2. van Heeswijk R, De Blois J, Kania G, Gonzales C, Blyszczuk P, Stuber M, Eriksson U, Schwitter J. Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance. Circ Cardiovasc Imaging 2013;6:277-284.
3. Afanasyeva M, Georgakopoulos D, Belardi DF, Ramsundar AC, Barin JG, Kass DA, Rose NR. Quantitative analysis of myocardial inflammation by flow cytometry in murine autoimmune myocarditis: correlation with cardiac function. Am J Pathol 2004;164:807-815.
4. Frisancho-Kiss S, Davis S, Nyland J, Frisancho J, Cihakova D, Barrett M, Rose N, Fairweather D. Cutting edge: cross-regulation by TLR 4, T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 2007;178: 6710-6714.
5. Fairweather D, Coronado M, Garton A, Dziedzic J, Bucek A, Cooper L, Brandt J, Alikhan F, Wang H, Endres C, Choi J, Pomper M, Guilarte T. Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation. J Cardiovasc Transl Res 2014;7:192-202.
6. Kania G, Blyszczuk P, Stein M, Valaperti A, Germano D, Dirnhofer S, Hunziker L, Matter C, Eriksson U. Heart-infiltrating prominin-1 +/CD133 + progenitor cells represent the cellular source of TGF-beta-mediated cardiac fibrosis in experimental autoimmune myocarditis. Circ Res 2009;105:462-470.
7. Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Silencing of CCR2 in myocarditis. Eur Heart J 2015;36:1478-1488.
8. Goser S, Ottl R, Brodner A, Dengler TJ, Torzewski J, Egashira K, Rose NR, Katus HA, Kaya Z. Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. Circulation 2005;112:3400-3407.
9. Coronado M, Brandt J, Kim E, Bucek A, Bedja D, Abston E, Shin J, Gabrielson K, Mitzner W, Fairweather D. Testosterone and interleukin-1b increase cardiac remodeling during acute coxsackievirus B3 myocarditis via serpin A. Am J Physiol Heart Circ Physiol 2012;302:H1726-H1736.
10. Kolattukudy P, Niu J Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1/CCR2 pathway. Circ Res 2012;110:174-189.
11. Frangogiannis NG, Dewald O, Xia Y, Ren G, Haudek S, Leucker T, Kraemer D, Taffet G, Rollins BJ, Entman ML. Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation 2007;115:584-592.
12. Hayashidani S, Tsutsui H, Shiomi T, Ikeuchi M, Matsusaka H, Suematsu N, Wen J, Egashira K, Takeshita A. Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2003;108:2134-2140.
13. Zhao Q. Dual targeting of CCR2 and CCR5: Therapeutic potential for immunologic and cardiovascular diseases. J Leuk Biol 2010;88:41-55.
14. Charo IF, Taub R. Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat Rev Drug Discov 2011;10:356-76.
15. McNamara DM, Starling RC, Cooper LT, Boehmer JP, Mather PJ, Janosko KM, Gorcsan J 3rd, Kip KE, Dec GW, IMAC Investigators. Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: Results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study. J Am Coll Cardiol 2011;58:1112-1118.
16. Fairweather D, Cooper LT Jr, Blauwet LA. Sex and gender differences in myocarditis and dilated cardiomyopathy. Curr Probl Cardiol 2013;38:7-46.