Murine fibroblastic reticular cells from lymph node interact with CD4+ T cells through CD40-CD40L

Transplantation

Volumn 99, Issue 8, 2015, Pages 1561-1567

  Nakayama, Yumi ^a,b   Brinkman, C Colin ^a,b   Bromberg, Jonathan S ^a,b,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c Transplantation Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CXCL2 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MESSENGER RNA; SECONDARY LYMPHOID TISSUE CHEMOKINE; AUTACOID; CYTOKINE; MONOCLONAL ANTIBODY;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL COMMUNICATION; CELL INTERACTION; CONTROLLED STUDY; DONOR SPECIFIC SPLENOCYTE TRANSFUSION; FIBROBLASTIC RETICULAR CELL; GENE EXPRESSION; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RETICULUM CELL; TRANSFUSION; ADOPTIVE TRANSFER; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; COCULTURE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; SIGNAL TRANSDUCTION; TIME; TRANSPLANTATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; FIBROBLASTS; GENE EXPRESSION REGULATION; IMMUNE TOLERANCE; INFLAMMATION MEDIATORS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84942474213     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000710     Document Type: Article

References (30)

1. Fletcher AL, Lukacs-Kornek V, Reynoso ED, et al. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010;207:689-697.
2. Fletcher AL, Malhotra D, Turley SJ. Lymph node stroma broaden the peripheral tolerance paradigm. Trends Immunol. 2011;32:12-18.
3. Reynoso ED, Lee JW, Turley SJ. Peripheral tolerance induction by lymph node stroma. Adv Exp Med Biol. 2009;633:113-127.
4. Berger DP, Naniche D, Crowley MT, et al. Lymphotoxin-beta-deficient mice show defective antiviral immunity. Virology. 1999;260:136-147.
5. Gunn MD, Kyuwa S, Tam C, et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med. 1999;189:451-460.
6. Mueller SN, Matloubian M, Clemens DM, et al. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007;104:15430-15435.
7. Nakayama Y, Bromberg JS. Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts. Am J Transplant. 2012;12:2322-2334.
8. Ehlers S, Holscher C, Scheu S, et al. The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. J Immunol. 2003;170:5210-15218.
9. Force WR, Walter BN, Hession C, et al. Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression. J Immunol. 1995;155: 5280-5288.
10. Ware CF, VanArsdale TL, Crowe PD, et al. The ligands and receptors of the lymphotoxin system. Curr Top Microbiol Immunol. 1995;198:175-218.
11. Siegert S, Luther SA. Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes. Front Immunol. 2012;3:285.
12. Lane P, Traunecker A, Hubele S, et al. Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J Immunol. 1992; 22:2573-2578.
13. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol. 2000; 67:2-17.
14. Banchereau J, Dubois B, Fayette J, et al. Functional CD40 antigen on B cells, dendritic cells and fibroblasts. Adv Exp Med Biol. 1995; 378:79-83.
15. Mach F, Schonbeck U, Libby P. CD40 signaling in vascular cells: a key role in atherosclerosis? Atherosclerosis. 1998;137(Suppl): S89-S95.
16. Burrell BE, Bromberg JS. Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure. Am J Transplant. 2012; 12:576-589.
17. Wekerle T, Kurtz J, Bigenzahn S, et al. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol. 2002;14: 592-600.
18. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996;381:434-438.
19. Jojic V, Shay T, Sylvia K, et al. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013;14:633-697.
20. Castle BE, Kishimoto K, Stearns C, et al. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J Immunol. 1993;151:1777-1788.
21. Renshaw BR, Fanslow WC 3rd, Armitage RJ, et al. Humoral immune responses in CD40 ligand-deficientmice. J Exp Med. 1994;180:1889-1900.
22. Khan O, Headley M, Gerard A, et al. Regulation of T cell priming by lymphoid stroma. PLoS One. 2011;6:e26138.
23. Siegert S, Huang HY, Yang CY, et al. Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. PLoS One. 2011;6:e27618.
24. Link A, Vogt TK, Favre S, et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 2007;8: 1255-1265.
25. Zeng M, Smith AJ, Wietgrefe SW, et al. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J Clin Invest. 2011;121:998-1008.
26. Fletcher AL, Malhotra D, Acton SE, et al. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front Immunol. 2011;2:35.
27. Marsland BJ, Battig P, Bauer M, et al. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity. 2005;22:493-505.
28. Ng CT, Nayak BP, Schmedt C, et al. Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection. Proc Natl Acad Sci U S A. 2012;109:7823-7828.
29. Cremasco V, Woodruff MC, Onder L, et al. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol. 2014; 15:978-981.
30. Denton AE, Roberts EW, Linterman MA, et al. Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proc Natl Acad Sci U S A. 2014;111:12139-12144.