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Volumn 2, Issue 1, 2014, Pages 21-26

Implications of Mesenchymal Cells in Cancer Stem Cell Populations: Relevance to EMT

Author keywords

Cancer stem cells (CSCs); Cell plasticity; Circulating tumor cells (CTCs); EMT; Epigenetics

Indexed keywords


EID: 84942426976     PISSN: None     EISSN: 2167485X     Source Type: Journal    
DOI: 10.1007/s40139-013-0034-7     Document Type: Article
Times cited : (34)

References (26)
  • 1
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial–mesenchymal transition
    • COI: 1:CAS:528:DC%2BD1MXntVCjtr0%3D, PID: 19487818
    • Kalluri R, Weinberg RA (2009) The basics of epithelial–mesenchymal transition. J Clin Investig 119:1420–1428
    • (2009) J Clin Investig , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 2
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial–mesenchymal transitions
    • COI: 1:CAS:528:DC%2BD1MXntVCjtro%3D, PID: 19487819
    • Zeisberg M, Neilson EG (2009) Biomarkers for epithelial–mesenchymal transitions. J Clin Investig 119:1429–1437
    • (2009) J Clin Investig , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 3
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it developmental dynamics
    • COI: 1:CAS:528:DC%2BD2MXmtFKgsrY%3D, PID: 15937929
    • Hay ED (2005) The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it developmental dynamics. Dev Dyn 233:706–720
    • (2005) Dev Dyn , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 4
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transitions in development and disease
    • COI: 1:CAS:528:DC%2BC3cXksFWltA%3D%3D, PID: 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial–mesenchymal transitions in development and disease. Cell 139:871–890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 5
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: current status and evolving complexities
    • COI: 1:CAS:528:DC%2BC38XosFCitLc%3D, PID: 22704512
    • Visvader JE, Lindeman GJ (2012) Cancer stem cells: current status and evolving complexities. Cell Stem Cell 10:717–728
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 7
    • 44349139461 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transition and the stem cell phenotype
    • COI: 1:CAS:528:DC%2BD1cXntFals7Y%3D, PID: 18522839
    • Radisky DC, LaBarge MA (2008) Epithelial–mesenchymal transition and the stem cell phenotype. Cell Stem Cell 2:511–512
    • (2008) Cell Stem Cell , vol.2 , pp. 511-512
    • Radisky, D.C.1    LaBarge, M.A.2
  • 9
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • One of the few in vivo demonstrations of metastasis showing pancreatic cancer cells with features of EMT and stemness. Some of these cancer stem cell like cells were in an “intermediate EMT”, simultaneously expressing both epithelial and mesenchymal markers
    • ∙ Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ (2012) EMT and dissemination precede pancreatic tumor formation. Cell 148:349–361. One of the few in vivo demonstrations of metastasis showing pancreatic cancer cells with features of EMT and stemness. Some of these cancer stem cell like cells were in an “intermediate EMT”, simultaneously expressing both epithelial and mesenchymal markers
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3    Maitra, A.4    Bailey, J.M.5    McAllister, F.6    Reichert, M.7    Beatty, G.L.8    Rustgi, A.K.9    Vonderheide, R.H.10    Leach, S.D.11    Stanger, B.Z.12
  • 11
    • 80052423435 scopus 로고    scopus 로고
    • Tracking the intermediate stages of epithelial–mesenchymal transition in epithelial stem cells and cancer
    • COI: 1:CAS:528:DC%2BC38XnvFKitA%3D%3D, PID: 21862874
    • Jordan NV, Johnson GL, Abell AN (2011) Tracking the intermediate stages of epithelial–mesenchymal transition in epithelial stem cells and cancer. Cell Cycle 10:2865–2873
    • (2011) Cell Cycle , vol.10 , pp. 2865-2873
    • Jordan, N.V.1    Johnson, G.L.2    Abell, A.N.3
  • 19
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial–mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • PID: 19589136
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S (2009) Stem cell and epithelial–mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 11:R46
    • (2009) Breast Cancer Res , vol.11 , pp. R46
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 20
    • 84861712713 scopus 로고    scopus 로고
    • Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis
    • COI: 1:CAS:528:DC%2BC38Xpt1aju7s%3D, PID: 22443102
    • Barriere G, Riouallon A, Renaudie J, Tartary M, Rigaud M (2012) Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis. BMC Cancer 12:114
    • (2012) BMC Cancer , vol.12 , pp. 114
    • Barriere, G.1    Riouallon, A.2    Renaudie, J.3    Tartary, M.4    Rigaud, M.5
  • 21
    • 84873823987 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition: a new insight into the detection of circulating tumor cells
    • PID: 22577580
    • Barriere G, Tartary M, Rigaud M (2012) Epithelial mesenchymal transition: a new insight into the detection of circulating tumor cells. ISRN Oncol 2012:382010
    • (2012) ISRN Oncol , vol.2012 , pp. 382010
    • Barriere, G.1    Tartary, M.2    Rigaud, M.3
  • 22
    • 84873811988 scopus 로고    scopus 로고
    • Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
    • Show EMT in CTCs that correlates with breast cancer treatment responses and relapse. Many of the mesenchymal CTCs circulated as multicellular clusters as compared to individual cells. This study clearly suggests the importance of EMT as a potential biomarker for therapeutic resistance and as a drug target in breast cancer
    • ∙ Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S (2013) Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science 339:580–584. Show EMT in CTCs that correlates with breast cancer treatment responses and relapse. Many of the mesenchymal CTCs circulated as multicellular clusters as compared to individual cells. This study clearly suggests the importance of EMT as a potential biomarker for therapeutic resistance and as a drug target in breast cancer
    • (2013) Science , vol.339 , pp. 580-584
    • Yu, M.1    Bardia, A.2    Wittner, B.S.3    Stott, S.L.4    Smas, M.E.5    Ting, D.T.6    Isakoff, S.J.7    Ciciliano, J.C.8    Wells, M.N.9    Shah, A.M.10    Concannon, K.F.11    Donaldson, M.C.12    Sequist, L.V.13    Brachtel, E.14    Sgroi, D.15    Baselga, J.16    Ramaswamy, S.17    Toner, M.18    Haber, D.A.19    Maheswaran, S.20    more..
  • 23
    • 84856015098 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transition, cancer stem cells and treatment resistance
    • PID: 22264257
    • Dave B, Mittal V, Tan NM, Chang JC (2012) Epithelial–mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Res 14:202
    • (2012) Breast Cancer Res , vol.14 , pp. 202
    • Dave, B.1    Mittal, V.2    Tan, N.M.3    Chang, J.C.4
  • 24
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • COI: 1:CAS:528:DC%2BC3cXntVSrur0%3D, PID: 20531305
    • Singh A, Settleman J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29:4741–4751
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 25
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • COI: 1:CAS:528:DC%2BD1MXhsVCjs73E, PID: 19682730
    • Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, Lander ES (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138:645–659
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.