Sphingosine 1-phosphate produced by sphingosine kinase 2 intrinsically controls platelet aggregation in vitro and in vivo

Circulation Research

Volumn 117, Issue 4, 2015, Pages 376-387

  Urtz, Nicole ^a,c   Gaertner, Florian ^a,c   Von Bruehl, Marie Luise ^a,c   Chandraratne, Sue ^a,c   Rahimi, Faridun ^a,c   Zhang, Lin ^d   Orban, Mathias ^a,c   Barocke, Verena ^a   Beil, Johannes ^a,c   Schubert, Irene ^a,c   Lorenz, Michael ^a,c   Legate, Kyle R ^a,b   Huwiler, Andrea ^e   Pfeilschifter, Josef M ^f   Beerli, Christian ^g   Ledieu, David ^g   Persohn, Elke ^g   Billich, Andreas ^g   Baumruker, Thomas ^g   Mederos Y Schnitzler, Michael ^b,c   Massberg, Steffen ^a   more..

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF BERN   (Switzerland)

^f UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^g NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Blood platelets; Platelet aggregation; Sphingosine 1 phosphate; Sphingosine kinase; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; MUTANT PROTEIN; PROTEINASE ACTIVATED RECEPTOR 4; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 2; ARACHIDONIC ACID; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; S1PR1 PROTEIN, MOUSE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE; THROMBOXANE A2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; BLOOD VESSEL INJURY; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HOMEOSTASIS; IMPEDANCE AGGREGOMETRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SPACE; INVESTIGATIVE PROCEDURES; MASS SPECTROMETRY; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BLOOD CLOTTING; BLOOD CLOTTING PARAMETERS; BLOOD CLOTTING TEST; C57BL MOUSE; CAROTID ARTERY INJURY; COMPARATIVE STUDY; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; ERYTHROCYTE; GENETICS; KNOCKOUT MOUSE; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOSIS;

ANIMALS; ARACHIDONIC ACID; BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CAROTID ARTERY INJURIES; DISEASE MODELS, ANIMAL; ERYTHROCYTES; LYSOPHOSPHOLIPIDS; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; THROMBOSIS; THROMBOXANE A2; VASCULAR SYSTEM INJURIES;

EID: 84942423855     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306901     Document Type: Article

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