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Volumn 21, Issue 3, 2015, Pages 94-97

Efavirenz: A review of the epidemiology, severity and management of neuropsychiatric side-effects

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; RALTEGRAVIR;

EID: 84942354086     PISSN: 16089685     EISSN: 20786786     Source Type: Journal    
DOI: 10.7196/SAJP.8260     Document Type: Article
Times cited : (10)

References (37)
  • 1
    • 85029297303 scopus 로고    scopus 로고
    • Statistics South Africa.Mid-year population estimate
    • Statistics South Africa. Mid-year population estimate. 2013. http://www.statssa.gov.za/publications/P0302/P03022013.pdf (accessed 13 February 2015).
    • (2013)
  • 2
    • 84942355421 scopus 로고    scopus 로고
    • AIDS Foundation South Africa
    • AIDS Foundation South Africa. http://www.aids.org.za/hivaids-in-south-africa/(accessed 12 September 2013).
  • 3
    • 85029281492 scopus 로고    scopus 로고
    • Avert: AVERTing HIV and AIDS
    • Avert: AVERTing HIV and AIDS. http://www.avert.org/hiv-and-aids-treatment-care.htm (accessed 13 February 2015).
  • 4
    • 84942355423 scopus 로고    scopus 로고
    • National Consolidated Guidelines for the Prevention of Mother-to-child Transmission of HIV (PMTCT) and the Management of HIV in Children, Pretoria:National Department of Health
    • National Consolidated Guidelines for the Prevention of Mother-to-child Transmission of HIV (PMTCT) and the Management of HIV in Children, Adolescents and Adults. 2014. Pretoria:National Department of Health, 2014.
    • (2014) Adolescents and Adults , vol.2014
  • 5
    • 78149244525 scopus 로고    scopus 로고
    • Implications of efavirenz for neuropsychiatry: A review
    • Cavalcante GIT, Capistrano VLM, Cavalcante FSD, et al. Implications of efavirenz for neuropsychiatry: A review. Int J Neurosci 2010; 120 (12):739-745. [http://dx.doi.org/10.3109/00207454.2010.520541]
    • (2010) Int J Neurosci , vol.120 , Issue.12 , pp. 739-745
    • Cavalcante, G.1    Capistrano, V.2    Cavalcante, F.3
  • 6
    • 85029304240 scopus 로고    scopus 로고
    • Space out drug discontinuations prior to ‘drug holiday’?
    • Piscitelli SC. Space out drug discontinuations prior to ‘drug holiday’? Medscape. 2000. http://www.medscape.com/viewarticle/413306 (accessed 1 September 2014).
    • (2000) Medscape
    • Piscitelli, S.C.1
  • 7
    • 84878378977 scopus 로고    scopus 로고
    • Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: A prospective cohort study
    • Mukonzo JK, Okwera A, Nakasujja N, et al. Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: A prospective cohort study. BMC Infect Dis 2013; 13 (261):1-11. [http://dx.doi.org/10.1186/1471-2334-13-261]
    • (2013) BMC Infect Dis , vol.13 , Issue.261 , pp. 1-11
    • Mukonzo, J.K.1    Okwera, A.2    Nakasujja, N.3
  • 8
    • 84900337388 scopus 로고    scopus 로고
    • Pharmacogenetic-based efavirenz dose modification: Suggestions for an African population and the different CYP2B6 genotypes
    • Mukonzo JK, Owen JS, Ogwal-Okeng J, et al. Pharmacogenetic-based efavirenz dose modification: Suggestions for an African population and the different CYP2B6 genotypes. Plos One 2014;9(1):1-9. [http://dx.doi.org/10.1371/journal.pone.0086919]
    • (2014) Plos One , vol.9 , Issue.1 , pp. 1-9
    • Mukonzo, J.K.1    Owen, J.S.2    Ogwal-Okeng, J.3
  • 9
    • 84896491775 scopus 로고    scopus 로고
    • Chetty M. Impact of CYP polymorphisms, ethnicity and sex differences in metabolism on dosing strategies: The case of efavirenz
    • Naidoo P, Chetty VV, Chetty M. Impact of CYP polymorphisms, ethnicity and sex differences in metabolism on dosing strategies: The case of efavirenz. Eur J Clin Pharmacol 2014; 70 (4):379-389. [http://dx.doi.org/10.1007/s00228-013-1634-1]
    • (2014) Eur J Clin Pharmacol , vol.70 , Issue.4 , pp. 379-389
    • Naidoo, P.1    Chetty, V.V.2
  • 10
    • 68249126599 scopus 로고    scopus 로고
    • Stepped-dose versus full dose efavirenz for HIV infection and neuropsychiatric adverse events: A randomized trial
    • Gutierrez-Valencia A, Viciana P, Palacios R, et al. Stepped-dose versus full dose efavirenz for HIV infection and neuropsychiatric adverse events: A randomized trial. Ann Intern Med 2011;151 (3):149-156. [http://dx.doi.org/10.7326/0003-4819-151-3-200908040-00127]
    • (2011) Ann Intern Med , vol.151 , Issue.3 , pp. 149-156
    • Gutierrez-Valencia, A.1    Viciana, P.2    Palacios, R.3
  • 11
    • 84555203868 scopus 로고    scopus 로고
    • A systematic review of the psychiatric side-effects of efavirenz
    • Kenedi CA, Goforth HW. A systematic review of the psychiatric side-effects of efavirenz. AIDS Behav 2011;15(8):1803-1808. [http://dx.doi.org/10.1007/s10461-011-9939-5]
    • (2011) AIDS Behav , vol.15 , Issue.8 , pp. 1803-1808
    • Kenedi, C.A.1    Goforth, H.W.2
  • 12
    • 0037271311 scopus 로고    scopus 로고
    • Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz
    • Lochet P, Peyriere H, Lotthe A, Mauboussin JM, Delmas B, Reynes J. Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz. HIV Med 2003; 4 (1):62-66. [http://dx.doi.org/10.1046/j.1468-1293.2003.00136.x]
    • (2003) HIV Med , vol.4 , Issue.1 , pp. 62-66
    • Lochet, P.1    Peyriere, H.2    Lotthe, A.3    Mauboussin, J.M.4    Delmas, B.5    Reynes, J.6
  • 13
    • 33847757854 scopus 로고    scopus 로고
    • Neuropsychiatric side effects of efavirenz therapy
    • Arendt G, de Nocker D, von Giesen H, Nolting T. Neuropsychiatric side effects of efavirenz therapy. Expert Opin Drug Saf 2007;6(2):147-154. [http://dx.doi.org/10.1517/14740338.6.2.147]
    • (2007) Expert Opin Drug Saf , vol.6 , Issue.2 , pp. 147-154
    • Arendt, G.1    De Nocker, D.2    Von Giesen, H.3    Nolting, T.4
  • 14
    • 79551577103 scopus 로고    scopus 로고
    • A comparison of neuropsychiatric adverse events during 12 weeks of treatment with etravirine and efavirenz in a treatmentnaive, HIV-1-infected population
    • Nelson M, Stellbrink H, Podzamczer D, et al. A comparison of neuropsychiatric adverse events during 12 weeks of treatment with etravirine and efavirenz in a treatmentnaive, HIV-1-infected population. AIDS 2011;25(3):335-340. [http://dx.doi.org/10.1097/QAD.0b013e3283416873]
    • (2011) AIDS , vol.25 , Issue.3 , pp. 335-340
    • Nelson, M.1    Stellbrink, H.2    Podzamczer, D.3
  • 15
    • 33744809516 scopus 로고    scopus 로고
    • Use of efavirenz is not associated with a higher risk of depressive disorders: A substudy of the randomized clinical trial ALIZE-ANRS 099
    • Journot V, Chene G, de Castro N, et al. Use of efavirenz is not associated with a higher risk of depressive disorders: A substudy of the randomized clinical trial ALIZE-ANRS 099. Clin Infect Dis 2006;42(12):1790-1799. [http://dx.doi.org/10.1086/504323]
    • (2006) Clin Infect Dis , vol.42 , Issue.12 , pp. 1790-1799
    • Journot, V.1    Chene, G.2    De Castro, N.3
  • 16
    • 84886790685 scopus 로고    scopus 로고
    • The end of AIDS: HIV infection as a chronic disease
    • Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet 2013;382(9903):1525-1533. [http://dx.doi.org/10.1016/S0140-6736(13)61809-7]
    • (2013) Lancet , vol.382 , Issue.9903 , pp. 1525-1533
    • Deeks, S.G.1    Lewin, S.R.2    Havlir, D.V.3
  • 17
    • 20244378824 scopus 로고    scopus 로고
    • Long-term neuropsychiatric disorders on efavirenz-based approaches: Quality of life, psychological issues, and adherence
    • Fumaz CR, Munoz-Moreno JA, Molto J, et al. Long-term neuropsychiatric disorders on efavirenz-based approaches: quality of life, psychological issues, and adherence. J Acq Immun Def Synd 2005;38(5):560-565. [http://dx.doi.org/10.1097/01.qai.0000147523.41993.47]
    • (2005) J Acq Immun Def Synd , vol.38 , Issue.5 , pp. 560-565
    • Fumaz, C.R.1    Munoz-Moreno, J.A.2    Molto, J.3
  • 18
    • 76749119501 scopus 로고    scopus 로고
    • Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG5097s)
    • Clifford DB, Evans S, Yang Y, Acosta EP, Ribaudo H, Gulick RM. Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG5097s). HIV Clin Trials 2009;10(6):343-355.
    • (2009) HIV Clin Trials , vol.10 , Issue.6 , pp. 343-355
    • Clifford, D.B.1    Evans, S.2    Yang, Y.3    Acosta, E.P.4    Ribaudo, H.5    Gulick, R.M.6
  • 20
    • 84942309251 scopus 로고    scopus 로고
    • Adco-Efavirenz package insert, Gauteng): Adcock Ingram
    • Adco-Efavirenz package insert. Midrand (Gauteng): Adcock Ingram, 2007.
    • (2007) Midrand
  • 21
    • 77956667215 scopus 로고    scopus 로고
    • Analysis of neuropsychiatric adverse events during clinical trials of efavirenz in antiretroviral-naïve patients
    • Gazzard B, Balkin A, Hill A. Analysis of neuropsychiatric adverse events during clinical trials of efavirenz in antiretroviral-naïve patients: A systematic review. AIDS Rev 2010;12(2):67-75.
    • (2010) A Systematic Review. AIDS Rev , vol.12 , Issue.2 , pp. 67-75
    • Gazzard, B.1    Balkin, A.2    Hill, A.3
  • 22
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1 infected patients
    • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1 infected patients. AIDS 2001;15(1):71-75. [http://dx.doi.org/10.1097/00002030-200101050-00011]
    • (2001) AIDS , vol.15 , Issue.1 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 23
    • 27744483263 scopus 로고    scopus 로고
    • Comparison of neuropsychiatric side effects in an observational cohort of efavirenz- and protease inhibitor-treated patients
    • Hawkins T, Geist C, Young B, et al. Comparison of neuropsychiatric side effects in an observational cohort of efavirenz- and protease inhibitor-treated patients. HIV Clin Trials 2005; 6 (4):187-196.
    • (2005) HIV Clin Trials , vol.6 , Issue.4 , pp. 187-196
    • Hawkins, T.1    Geist, C.2    Young, B.3
  • 24
    • 77955694290 scopus 로고    scopus 로고
    • Presence of CYP2B6 516G> T polymorphism, increased plasma efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients
    • Gounden V, van Niekerk C, Snyman T, George JA. Presence of CYP2B6 516G> T polymorphism, increased plasma efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients. AIDS Res Ther 2010; 7(32):1-9. [http://dx.doi.org/10.1186/1742-6405-7-32]
    • (2010) AIDS Res Ther , vol.7 , Issue.32 , pp. 1-9
    • Gounden, V.1    Van Niekerk, C.2    Snyman, T.3    George, J.A.4
  • 25
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection: Amulticentre, double-blind, randomised controlled trial
    • Lennox JL, DeJesus E, Lazzarin A, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection: Amulticentre, double-blind, randomised controlled trial. Lancet 2009; 374(9692):796-806. [http://dx.doi.org/10.1016/s0140-6736(09)60918-1]
    • (2009) Lancet , vol.374 , Issue.9692 , pp. 796-806
    • Lennox, J.L.1    Dejesus, E.2    Lazzarin, A.3
  • 26
    • 85027932899 scopus 로고    scopus 로고
    • Changes in patient-reported neuropsychiatric outcomes during the SENSE trial: First-line treatment with two nucleoside analogues plus etravirine or efavirenz
    • Orkin C, Nelson M, Katlama C, et al. Changes in patient-reported neuropsychiatric outcomes during the SENSE trial: First-line treatment with two nucleoside analogues plus etravirine or efavirenz. Health Outcomes Res Med 2012; 3(3):113-119. [http://dx.doi.org/10.1016/j.ehrm.2012.06.002]
    • (2012) Health Outcomes Res Med , vol.3 , Issue.3 , pp. 113-119
    • Orkin, C.1    Nelson, M.2    Katlama, C.3
  • 27
    • 28044459173 scopus 로고    scopus 로고
    • Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring
    • Gutierrez F, Navarro A, Padillo S, et al. Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring. Clin Infect Dis 2005;41(11):1648-1653. [http://dx.doi.org/10.1086/497835]
    • (2005) Clin Infect Dis , vol.41 , Issue.11 , pp. 1648-1653
    • Gutierrez, F.1    Navarro, A.2    Padillo, S.3
  • 28
    • 33750999952 scopus 로고    scopus 로고
    • Efavirenz and chronic neuropsychiatric symptoms: A cross-sectional case control study
    • Rihs TA, Begley K, Smith DE, et al. Efavirenz and chronic neuropsychiatric symptoms: A cross-sectional case control study. HIV Med 2006;7(8):544-548. [http://dx.doi.org/10.1111/j.1468-1293.2006.00419.x]
    • (2006) HIV Med , vol.7 , Issue.8 , pp. 544-548
    • Rihs, T.A.1    Begley, K.2    Smith, D.E.3
  • 30
    • 11444268737 scopus 로고    scopus 로고
    • Psychiatric side effects of medications: Recent developments
    • Turjanski N, Llyod GG. Psychiatric side effects of medications: Recent developments. Adv Psychiatr Treat 2005;11:58-70. [http://dx.doi.org/10.1192/apt.11.1.58]
    • (2005) Adv Psychiatr Treat , vol.11 , pp. 58-70
    • Turjanski, N.1    Llyod, G.G.2
  • 31
    • 0037076706 scopus 로고    scopus 로고
    • Neurologic and psychiatric complications of antiretroviral agents
    • Treisman GJ, Kaplin AI. Neurologic and psychiatric complications of antiretroviral agents. AIDS 2002; 16(9):1201-1215. [http://dx.doi.org/10.1097/00002030-200206140-00002]
    • (2002) AIDS , vol.16 , Issue.9 , pp. 1201-1215
    • Treisman, G.J.1    Kaplin, A.I.2
  • 32
    • 65349157832 scopus 로고    scopus 로고
    • Management of common psychiatric conditions in the HIV-positive population
    • Brogan K, Lux J. Management of common psychiatric conditions in the HIV-positive population. Curr HIV/AIDS Rep 2009;6(2):108-115. [http://dx.doi.org/10.1007/s11904-009-0016-x]
    • (2009) Curr HIV/AIDS Rep , vol.6 , Issue.2 , pp. 108-115
    • Brogan, K.1    Lux, J.2
  • 33
    • 65749109259 scopus 로고    scopus 로고
    • Psychopharmacologic treatment of patients with HIV/AIDS
    • Ferrando SJ. Psychopharmacologic treatment of patients with HIV/AIDS. Curr Psychiatry Rep 2009; 11(3):235-242. [http://dx.doi.org/10.1007/s11920-009-0036-7]
    • (2009) Curr Psychiatry Rep , vol.11 , Issue.3 , pp. 235-242
    • Ferrando, S.J.1
  • 34
    • 73849086228 scopus 로고    scopus 로고
    • Assessment and treatment of psychosis in people living with HIV/AIDS
    • Jonsson G, Joska JA. Assessment and treatment of psychosis in people living with HIV/AIDS. S Afr J HIV Med 2009; 10(3):20-27.
    • (2009) S Afr J HIV Med , vol.10 , Issue.3 , pp. 20-27
    • Jonsson, G.1    Joska, J.A.2
  • 35
    • 76749112870 scopus 로고    scopus 로고
    • Substitution of nevirapine because of efavirenz toxicity in AIDS Clinical Trials Group A5095
    • Schouten JT, Krambrink A, Ribaudo HJ, et al. Substitution of nevirapine because of efavirenz toxicity in AIDS Clinical Trials Group A5095. Clin Infect Dis 2010;50(5):787-791. [http://dx.doi.org/10.1086/650539]
    • (2010) Clin Infect Dis , vol.50 , Issue.5 , pp. 787-791
    • Schouten, J.T.1    Krambrink, A.2    Ribaudo, H.J.3
  • 36
    • 0003966928 scopus 로고    scopus 로고
    • 10th ed. Cape Town: Health and Medical Publishing Group
    • Rossiter D, ed. South African Medicines Formulary. 10th ed. Cape Town: Health and Medical Publishing Group, 2012
    • (2012) South African Medicines Formulary
    • Rossiter, D.1


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