메뉴 건너뛰기




Volumn 7, Issue , 2010, Pages

Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B6; EFAVIRENZ; GUANINE; THREONINE;

EID: 77955694290     PISSN: 17426405     EISSN: None     Source Type: Journal    
DOI: 10.1186/1742-6405-7-32     Document Type: Article
Times cited : (114)

References (31)
  • 1
    • 77956411377 scopus 로고    scopus 로고
    • UNAIDS 2008 Report on the global AIDS epidemic, August 2008
    • UNAIDS 2008 Report on the global AIDS epidemic, August 2008. , http://www.unaids.org/en/KnowledgeCentre/HIVData/GlobalReport/2008/2008_Global_report.asp
  • 2
    • 77956400574 scopus 로고    scopus 로고
    • FDA drug information sheet
    • FDA drug information sheet. , http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020972s026,021360s013lbl.pdf
  • 3
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma concentrations can predict treatment failure and central nervous system side effects in HIV-1 infected patients
    • 10.1097/00002030-200101050-00011, 11192870
    • Marzolini C, Telenti A, Decosterd LA, et al. Efavirenz plasma concentrations can predict treatment failure and central nervous system side effects in HIV-1 infected patients. AIDS 2001, 15:71-75. 10.1097/00002030-200101050-00011, 11192870.
    • (2001) AIDS , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3
  • 4
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    • Haas D, Ribaudo HJ, Kim RB, Camlin T, et al. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 2004, 18:2391-2400.
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.1    Ribaudo, H.J.2    Kim, R.B.3    Camlin, T.4
  • 5
    • 0038322628 scopus 로고    scopus 로고
    • Advances in HIV Pharmacology: Protein Binding, Pharmacogenomics and Therapeutic Drug Monitoring
    • Flexner D. Advances in HIV Pharmacology: Protein Binding, Pharmacogenomics and Therapeutic Drug Monitoring. Top HIV Med 2003, 11:40-44.
    • (2003) Top HIV Med , vol.11 , pp. 40-44
    • Flexner, D.1
  • 6
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • Ward BA, Gorski JC, Jones DR, Hall SD, et al. The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol ExpTherapy 2003, 306:287-300.
    • (2003) J Pharmacol ExpTherapy , vol.306 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3    Hall, S.D.4
  • 7
    • 0024464027 scopus 로고
    • CDNA cloning and sequence and cDNA-directed expression of human P450 iiB1
    • 10.1021/bi00444a029, 2573390
    • Yamano S, Nhambura PA, et al. cDNA cloning and sequence and cDNA-directed expression of human P450 iiB1. Biochemistry 1989, 28:7340-7348. 10.1021/bi00444a029, 2573390.
    • (1989) Biochemistry , vol.28 , pp. 7340-7348
    • Yamano, S.1    Nhambura, P.A.2
  • 8
    • 33644588715 scopus 로고    scopus 로고
    • Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism if the HIV drug efavirenz
    • 10.1097/01.fpc.0000230119.34205.8a, 16495778
    • Wang J, Sonnenerborg A, Rane A, et al. Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism if the HIV drug efavirenz. Pharmacogenet Genomics 2006, 16:191-198. 10.1097/01.fpc.0000230119.34205.8a, 16495778.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 191-198
    • Wang, J.1    Sonnenerborg, A.2    Rane, A.3
  • 9
    • 33947382259 scopus 로고    scopus 로고
    • Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrationsin HIV-infected Individuals
    • Rotger M, Tegude H, Colombo S, et al. Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrationsin HIV-infected Individuals. J Clin Pharm Ther 2007, 81:557-566.
    • (2007) J Clin Pharm Ther , vol.81 , pp. 557-566
    • Rotger, M.1    Tegude, H.2    Colombo, S.3
  • 10
    • 27944492382 scopus 로고    scopus 로고
    • Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy efavirenz
    • 10.1097/01213011-200512000-00004, 16272958
    • Klein K, Lang T, Saussele T, et al. Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy efavirenz. Pharmacogenet Genomics 2005, 15:861-879. 10.1097/01213011-200512000-00004, 16272958.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 861-879
    • Klein, K.1    Lang, T.2    Saussele, T.3
  • 11
    • 33645683551 scopus 로고    scopus 로고
    • Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea
    • 10.1007/s00228-005-0092-9, 16506047
    • Mehlotra RK, Ziats MN, Bockarie MJ, et al. Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea. Eur J Clin Pharmacol 2006, 62:267-275. 10.1007/s00228-005-0092-9, 16506047.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 267-275
    • Mehlotra, R.K.1    Ziats, M.N.2    Bockarie, M.J.3
  • 12
    • 40049092364 scopus 로고    scopus 로고
    • High prevalence of the CYP2B6 516G→T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe
    • 10.1007/s00228-007-0412-3, 18057928
    • Nyakutira C, Röshammar D, Chigutsa E, et al. High prevalence of the CYP2B6 516G→T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe. Eur J Clin Pharmacol 2008, 64:357-365. 10.1007/s00228-007-0412-3, 18057928.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 357-365
    • Nyakutira, C.1    Röshammar, D.2    Chigutsa, E.3
  • 13
    • 77956417498 scopus 로고    scopus 로고
    • The Royal College of Psychiatrists, Alcohol related disorders
    • The Royal College of Psychiatrists, Alcohol related disorders. , http://www.rcpsych.ac.uk/default.aspx?page
  • 14
    • 77956404996 scopus 로고    scopus 로고
    • American National Institute of Health, Division for Acquired Immune Deficiency Syndrome Toxicity Grading, August 2005
    • American National Institute of Health, Division for Acquired Immune Deficiency Syndrome Toxicity Grading, August 2005. , http://www.fda.gov/OHRMS/DOCKETS/dockets/05d0155/05D-0155_emc-000002-02.pdf
  • 15
    • 80052855594 scopus 로고    scopus 로고
    • Preliminary Evaluation of Quantitative Clinical Laboratory Methods, Approved Guideline - EP10A3
    • CLSI/NCCLS, 3
    • Krouwer JS. Preliminary Evaluation of Quantitative Clinical Laboratory Methods, Approved Guideline - EP10A3. 2006, CLSI/NCCLS, 3.
    • (2006)
    • Krouwer, J.S.1
  • 16
    • 28144452516 scopus 로고    scopus 로고
    • Impact of Efavirenz on Neuropsychiatric Performance and Symptoms in HIV-infected individuals
    • Clifford D, Evans S, Yang Y, et al. Impact of Efavirenz on Neuropsychiatric Performance and Symptoms in HIV-infected individuals. Ann Intern Med 2005, 143:714-721.
    • (2005) Ann Intern Med , vol.143 , pp. 714-721
    • Clifford, D.1    Evans, S.2    Yang, Y.3
  • 17
    • 77956395968 scopus 로고    scopus 로고
    • Online Encyclopaedia for Genetic Epidemiology Studies
    • Online Encyclopaedia for Genetic Epidemiology Studies. , http://www.genes.org.uk/software/hardy-weinberg.shtml
  • 18
    • 35348923463 scopus 로고    scopus 로고
    • Successful Efavirenz Dose Reduction in HIV Type 1-Infected Individuals with Cytochrome P450 2B6 *6 and *26
    • 10.1086/522175, 17918089
    • Gatanaga H, Hayashida T, Tsuchiya K, et al. Successful Efavirenz Dose Reduction in HIV Type 1-Infected Individuals with Cytochrome P450 2B6 *6 and *26. Clin Infect Dis 2007, 45:1230-7. 10.1086/522175, 17918089.
    • (2007) Clin Infect Dis , vol.45 , pp. 1230-1237
    • Gatanaga, H.1    Hayashida, T.2    Tsuchiya, K.3
  • 19
    • 20244378824 scopus 로고    scopus 로고
    • Long-term Neuropsychiatric disorders on Efavirenz based approaches: Quality of life, Psychological issues and adherence
    • Fumaz CR, Munoz-Moreno BS, Molto J, et al. Long-term Neuropsychiatric disorders on Efavirenz based approaches: Quality of life, Psychological issues and adherence. JAIDS 2005, 38:560-565.
    • (2005) JAIDS , vol.38 , pp. 560-565
    • Fumaz, C.R.1    Munoz-Moreno, B.S.2    Molto, J.3
  • 20
    • 2542549644 scopus 로고    scopus 로고
    • Efavirenz Plasma Concentrations in HIV-Infected Patients Inter- and Intraindividual Variability and Clinical Effects
    • 10.1097/00007691-200406000-00008, 15167626
    • Ståhle L, Moberg L, Svensson J, et al. Efavirenz Plasma Concentrations in HIV-Infected Patients Inter- and Intraindividual Variability and Clinical Effects. Ther Drug Monit 2004, 26:267-270. 10.1097/00007691-200406000-00008, 15167626.
    • (2004) Ther Drug Monit , vol.26 , pp. 267-270
    • Ståhle, L.1    Moberg, L.2    Svensson, J.3
  • 21
    • 3042726798 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2004 recommendations of the International AIDS society - USA panel
    • 10.1001/jama.292.2.251, 15249575
    • Yeni P, Hammer S, Hirsch M, et al. Treatment for adult HIV infection: 2004 recommendations of the International AIDS society - USA panel. JAMA 2004, 292:251-265. 10.1001/jama.292.2.251, 15249575.
    • (2004) JAMA , vol.292 , pp. 251-265
    • Yeni, P.1    Hammer, S.2    Hirsch, M.3
  • 22
    • 0035696398 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of nonnucleoside reverse transcriptase inhibitors
    • 10.2165/00003088-200140120-00002, 11735608
    • Smith PF, DiCenzo R, Morse GD. Clinical pharmacokinetics of nonnucleoside reverse transcriptase inhibitors. Clin Pharmacokinet 2001, 40:893-905. 10.2165/00003088-200140120-00002, 11735608.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 893-905
    • Smith, P.F.1    DiCenzo, R.2    Morse, G.D.3
  • 23
    • 57049168210 scopus 로고    scopus 로고
    • HIV Type 1 Subtype C Drug Resistance among Pediatric and Adult South African Patients Failing Antiretroviral Therapy
    • 10.1089/aid.2008.0180, 19000027
    • Pillay V, Pillay C, Kantor R, et al. HIV Type 1 Subtype C Drug Resistance among Pediatric and Adult South African Patients Failing Antiretroviral Therapy. AIDS Res Hum Retroviruses 2008, 24:1449-1454. 10.1089/aid.2008.0180, 19000027.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 1449-1454
    • Pillay, V.1    Pillay, C.2    Kantor, R.3
  • 24
    • 41149092923 scopus 로고    scopus 로고
    • Impact of CYP2B6 983T > C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients
    • 10.1093/jac/dkn029, 18281305
    • Wyen C, Hendra H, Hoffman C, et al. Impact of CYP2B6 983T > C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients. J Antimicrob Chemother 2008, 61:914-8. 10.1093/jac/dkn029, 18281305.
    • (2008) J Antimicrob Chemother , vol.61 , pp. 914-918
    • Wyen, C.1    Hendra, H.2    Hoffman, C.3
  • 25
    • 77952322356 scopus 로고    scopus 로고
    • CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    • 10.1097/QAD.0b013e3283319908, 19779319
    • Kwara A, Lartey M, Sagoe KWC, et al. CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients. AIDS 2009, 23:2101-2106. 10.1097/QAD.0b013e3283319908, 19779319.
    • (2009) AIDS , vol.23 , pp. 2101-2106
    • Kwara, A.1    Lartey, M.2    Sagoe, K.W.C.3
  • 26
    • 63849240305 scopus 로고    scopus 로고
    • In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function
    • 10.1097/FPC.0b013e328328d577, 19238117
    • di Iulio J, lie Fayet A, Arab-Alameddine M, et al. In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function. Pharmacogenet Genomics 2009, 19:300-309. 10.1097/FPC.0b013e328328d577, 19238117.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 300-309
    • di Iulio, J.1    lie Fayet, A.2    Arab-Alameddine, M.3
  • 27
    • 23244462148 scopus 로고    scopus 로고
    • Therapeutic Drug Monitoring of Efavirenz: Trough Levels Cannot Be Estimated on the Basis of Earlier Plasma Determinations
    • López-Cortés L, Ruiz-Valderas R, Marín-Niebla A, et al. Therapeutic Drug Monitoring of Efavirenz: Trough Levels Cannot Be Estimated on the Basis of Earlier Plasma Determinations. JAIDS 2005, 39:551-556.
    • (2005) JAIDS , vol.39 , pp. 551-556
    • López-Cortés, L.1    Ruiz-Valderas, R.2    Marín-Niebla, A.3
  • 28
    • 0037256015 scopus 로고    scopus 로고
    • Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection
    • 10.1067/mcp.2003.22, 12545140
    • Csajka C, Marzolini C, Fattinger K, et al. Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection. Clin Pharmacol Ther 2003, 73:20-30. 10.1067/mcp.2003.22, 12545140.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 20-30
    • Csajka, C.1    Marzolini, C.2    Fattinger, K.3
  • 29
    • 0037167163 scopus 로고    scopus 로고
    • Efavirenz plasma levels for the prediction of treatment failure in heavily pre-treated HIV-1 infected patients
    • Langmann P, Weissbrich B, Desch S, et al. Efavirenz plasma levels for the prediction of treatment failure in heavily pre-treated HIV-1 infected patients. Eur J Med Res 2002, 7:309-314.
    • (2002) Eur J Med Res , vol.7 , pp. 309-314
    • Langmann, P.1    Weissbrich, B.2    Desch, S.3
  • 30
    • 0035876396 scopus 로고    scopus 로고
    • Efavirenz plasma concentrations and efficiency
    • 10.1097/00002030-200106150-00022, 11416729
    • López-Cortés LF, Alarcón A, Viciana P, et al. Efavirenz plasma concentrations and efficiency. AIDS 2001, 15:1192-1193. 10.1097/00002030-200106150-00022, 11416729.
    • (2001) AIDS , vol.15 , pp. 1192-1193
    • López-Cortés, L.F.1    Alarcón, A.2    Viciana, P.3
  • 31
    • 48749098848 scopus 로고    scopus 로고
    • Outcomes of Nevirapine- and Efavirenz-Based Antiretroviral Therapy When Co administered With Rifampicin-Based Antitubercular Therapy
    • 10.1001/jama.300.5.530, 18677025
    • Boulle A, Van Cutsem G, Cohen K, et al. Outcomes of Nevirapine- and Efavirenz-Based Antiretroviral Therapy When Co administered With Rifampicin-Based Antitubercular Therapy. JAMA 2008, 300:530-9. 10.1001/jama.300.5.530, 18677025.
    • (2008) JAMA , vol.300 , pp. 530-539
    • Boulle, A.1    Van Cutsem, G.2    Cohen, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.