Single high-dose oral Vitamin D3 therapy (Stoss): A solution to Vitamin D deficiency in children with inflammatory bowel disease?

Journal of Pediatric Gastroenterology and Nutrition

Volumn 61, Issue 4, 2015, Pages 411-414

  Shepherd, Darren ^a   Day, Andrew S ^b   Leach, Steven T ^c   Lopez, Robert ^b   Messenger, Rachel ^a   Woodhead, Helen J ^a   Ledder, Oren ^d   Lemberg, Daniel A ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

Inflammatory bowel disease; Stoss therapy; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; CALCIUM; COLECALCIFEROL; HEMOGLOBIN; PARATHYROID HORMONE; PHOSPHATE; SERUM ALBUMIN; CALCIFEDIOL;

ADOLESCENT; ALBUMIN BLOOD LEVEL; ARTICLE; CALCIUM BLOOD LEVEL; CHILD; CHILDHOOD DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; CROHN DISEASE ACTIVITY INDEX; DISEASE ACTIVITY; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; DRUG SAFETY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATORY BOWEL DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NEPHROLITHIASIS; NUTRITIONAL ASSESSMENT; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; SIDE EFFECT; STOSS THERAPY; SUBSTITUTION THERAPY; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ADVERSE EFFECTS; BLOOD; COHORT ANALYSIS; COMPLICATION; CROHN DISEASE; DIET THERAPY; DIETARY SUPPLEMENT; FOLLOW UP; HOSPITAL; MEDICAL RECORD; METABOLISM; NEW SOUTH WALES; OUTPATIENT DEPARTMENT; PATHOPHYSIOLOGY; PRESCHOOL CHILD; ULCERATIVE COLITIS;

ADOLESCENT; CALCIFEDIOL; CHILD; CHILD, PRESCHOOL; CHOLECALCIFEROL; COHORT STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; HOSPITALS, PEDIATRIC; HUMANS; INFLAMMATORY BOWEL DISEASES; MALE; MEDICAL RECORDS; NEW SOUTH WALES; OUTPATIENT CLINICS, HOSPITAL; RETROSPECTIVE STUDIES; VITAMIN D DEFICIENCY;

EID: 84942334487     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000823     Document Type: Article

References (21)

1. Day AS, Ledder O, Leach ST, et al. Crohn's and colitis in children and adolescents. World J Gastroenterol 2012;18:5862-9.
2. Rufo PA, Denson LA, Sylvester FA, et al. Health supervision in the management of children and adolescents with IBD: NASPGHAN recommendations. J Pediatr Gastroenterol Nutr 2012;55:93-108.
3. Green D, Carson K, Leonard A, et al. Current treatment recommendations for correcting vitamin D deficiency in pediatric patients with cystic fibrosis are inadequate. J Pediatr 2008;153:554-9.
4. Cesur Y, Caksen H, Gundem A, et al. Comparison of low and high dose vitamin D treatment in nutritional vitamin D deficient rickets. J Pediatr Endocrinol Metab 2003;16:1105-9.
5. Pappa HM, Gordon CM, Saslowsky TM, et al. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics 2006;118:1950-61.
6. Belostotsky V, Mughal Z. A single high dose of ergocalciferol can be used to boost 25-hydroxyvitamin D levels in children. Pediatr Nephrol 2009;24:625-6.
7. Bordelon P, Ghetu M, Langan R. Recognition and management of vitamin D deficiency. Am Fam Physician 2009;80:841-6.
8. Zhao H, Zhang H,Wu H, et al. Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol 2012;12:57.
9. Shepherd DP, Belessis Y, Katz T, et al. Single high-dose oral vitamin D3 (stoss) therapy-a solution to vitamin D deficiency in children with cystic fibrosis? J Cyst Fibros 2013;12:177-82.
10. Khazai N, Judd S, Jeng L, et al. Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol and UV light. J Clin Endocrinol Metab 2009;94:2037-43.
11. Diamond T, Ho K, Rohl P, et al. Annual intramuscular injection of megadose of cholecalciferol for treatment of vitamin D deficiency: efficacy and safety data. Med J Aust 2005;183:10-2.
12. Harms HK, Blomer R, Bertele-Harms RM, et al. A paediatric Crohn's disease activity index (PCDAI). Is it useful? Study Group on Crohn's Disease in Children and Adolescents. Acta Paediatr Suppl 1994;395: 22-6.
13. Pappa HM, Langereis EJ, Grand RJ, et al. Prevalence and risk factors for hypovitaminosis D in young patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2011;53:361-4.
14. Levin AD,Wadhera V, Leach ST, et al. Vitamin D deficiency in children with inflammatory bowel disease. Dig Dis Sci 2011;56:830-6.
15. Paxton GA, Teale GR, Nowson CA, et al. Vitamin D and health in pregnancy, infants, children and adolescents in Australia and New Zealand: a position statement. Med J Aust 2013;198:142-3.
16. Heaney RP. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 2004;80 (6 suppl):1706S-9.
17. Pappa HM, Mitchell PD, Jiang H, et al. Treatment of vitamin D insufficiency in children and adolescents with inflammatory bowel disease: a randomised control trial comparing three regimes. J Clin Endocrinol Metab 2012;97:2134-42.
18. Heaney RP, Armas LA, Shary JR, et al. 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 2008;87:1738-42.
19. Ilahi M, Armas LA, Heaney RP. Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr 2008;87:688-91.
20. Kappelman MD, Galanko JA, Porter CQ, et al. Risk of diagnosed fractures in children with inflammatory bowel disease. Inflamm Bowel Dis 2011;17:1125-30.
21. Vazquez MA, Lopez E, Montoya MJ, et al. Vertebral fractures in patients with inflammatory bowel disease compared with a healthy population: a prospective case-control study. BMC Gastroenterol 2012; 12:47.