Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zhu, Wenfei ^a,b,c   Li, Long ^b   Yan, Zhigang ^b   Gan, Tanhuan ^b,c   Li, Lifeng ^b,c   Chen, Rirong ^b,c   Chen, Ruidong ^b   Zheng, Zuoyi ^b,c   Hong, Wenshan ^b   Wang, Jia ^b,c   Smith, David K ^b,c   Guan, Yi ^b,c   Zhu, Huachen ^b,c   Shu, Yuelong ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^c THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CODON; PB2 PROTEIN, INFLUENZAVIRUS A; RNA DIRECTED RNA POLYMERASE; VIRAL PROTEIN;

ANIMAL; CODON; DISEASE MODEL; ENZYME ACTIVATION; FERRET; GENETIC RECOMBINATION; GENETICS; HUMAN; INFLUENZA A VIRUS (H7N9); METABOLISM; MORTALITY; MOUSE; MUTATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PHYSIOLOGY; TEMPERATURE; TRANSMISSION; VIRAL TROPISM; VIROLOGY; VIRULENCE; VIRUS REPLICATION; VIRUS SHEDDING;

ANIMALS; CODON; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FERRETS; HUMANS; INFLUENZA A VIRUS, H7N9 SUBTYPE; MICE; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; RECOMBINATION, GENETIC; RNA REPLICASE; TEMPERATURE; VIRAL PROTEINS; VIRAL TROPISM; VIRULENCE; VIRUS REPLICATION; VIRUS SHEDDING;

EID: 84942279746     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14170     Document Type: Article

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