Cerebral blood velocity regulation during progressive blood loss compared with lower body negative pressure in humans

Journal of Applied Physiology

Volumn 119, Issue 6, 2015, Pages 677-685

  Rickards, Caroline A ^a   Johnson, Blair D ^b   Harvey, Ronée E ^b   Convertino, Victor A ^c   Joyner, Michael J ^b   Barnes, Jill N ^b,d  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b DEPARTMENT OF UROLOGY   (United States)

^c US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

Cerebrovascular; Hypovolemia; Simulated hemorrhage

Indexed keywords

ADULT; ARTERIAL PRESSURE; BLEEDING; BRAIN; BRAIN CIRCULATION; CENTRAL VENOUS PRESSURE; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HUMAN; HYPOVOLEMIA; LOWER BODY NEGATIVE PRESSURE; MALE; MIDDLE CEREBRAL ARTERY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

ADULT; ARTERIAL PRESSURE; BRAIN; CENTRAL VENOUS PRESSURE; CEREBROVASCULAR CIRCULATION; HEART RATE; HEMODYNAMICS; HEMORRHAGE; HUMANS; HYPOVOLEMIA; LOWER BODY NEGATIVE PRESSURE; MALE; MIDDLE CEREBRAL ARTERY; STROKE VOLUME;

EID: 84942245211     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00127.2015     Document Type: Article

References (55)

1. Barcroft H, Edholm OG, McMichael J, Sharpey-Schafer EP. Posth-aemorrhagic fainting study by cardiac output and forearm flow. Lancet 1: 489-491, 1944.
2. Bassin R, Vladeck BC, Kark AE, Shoemaker WC. Rapid and slow hemorrhage in man. I Sequential hemodynamic responses. Ann Surg 173: 325-330, 1971.
3. Bondar RL, Kassam MS, Stein F, Dunphy PT, Fortney S, Riedesel ML. Simultaneous cerebrovascular and cardiovascular responses during presyncope. Stroke 26: 1794-1800, 1995.
4. Brown CM, Dutsch M, Hecht MJ, Neundorfer B, Hilz MJ. Assessment of cerebrovascular and cardiovascular responses to lower body negative pressure as a test of cerebral autoregulation. J Neurol Sci 208: 71-78, 2003.
5. Brown CM, Dutsch M, Ohring S, Neundorfer B, Hilz MJ. Cerebral autoregulation is compromised during simulated fluctuations in gravitational stress. Eur J Appl Physiol 91: 279-286, 2004.
6. Brown E, Goei JS, Greenfield AD, Plassaras GC. Circulatory responses to simulated gravitational shifts of blood in man induced by exposure of the body below the iliac crests to sub-atmospheric pressure. J Physiol 183: 607-627, 1966.
7. Colier WN, Binkhorst RA, Hopman MT, Oeseburg B. Cerebral and circulatory haemodynamics before vasovagal syncope induced by ortho-static stress. Clin Physiol 17: 83-94, 1997.
8. Convertino VA, Grudic G, Mulligan J, Moulton S. Estimation of individual-specific progression to impending cardiovascular instability using arterial waveforms. J Appl Physiol 115: 1196-1202, 2013.
9. Convertino VA, Rickards CA, Lurie KG, Ryan KL. Hyperventilation in response to progressive reduction in central blood volume to near syncope. Aviat Space Environ Med 80: 1012-1017, 2009.
10. Convertino VA, Ryan KL, Rickards CA, Cooke WH, Metzger A, Holcomb JB, Adams BD, Lurie KG. Inspiratory resistance maintains arterial pressure during central hypovolemia: implications for treatment of patients with severe hemorrhage. Crit Care Med 35: 1145-1152, 2007.
11. Convertino VA, Sather TM. Vasoactive neuroendocrine responses associated with tolerance to lower body negative pressure in humans. Clin Physiol 20: 177-184, 2000.
12. Cooke WH, Rickards CA, Ryan KL, Kuusela TA, Convertino VA. Muscle sympathetic nerve activity during intense lower body negative pressure to presyncope in humans. J Physiol 587: 4987-4999, 2009.
13. Cooke WH, Ryan KL, Convertino VA. Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans. J Appl Physiol 96: 1249-1261, 2004.
14. Coverdale NS, Gati JS, Opalevych O, Perrotta A, Shoemaker JK. Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia. J Appl Physiol 117: 1090-1096, 2014.
15. Eastridge BJ, Mabry RL, Seguin P, Cantrell J, Tops T, Uribe P, Mallett O, Zubko T, Oetjen-Gerdes L, Rasmussen TE, Butler FK, Kotwal RS, Holcomb JB, Wade C, Champion H, Lawnick M, Moores L, Blackbourne LH. Death on the battlefield (2001-2011): implications for the future of combat casualty care. J Trauma Acute Care Surg 73: S431-S437, 2012.
16. Ebert RV, Stead EA. The effect of the application of tourniquets on the hemodynamics of the circulation. J Clin Invest 19: 561-567, 1940.
17. Giller CA. The frequency-dependent behaviours of cerebral autoregula-tion. Neurosurgery 27: 362-368, 1990.
18. Greenleaf JE, Petersen TW, Gabrielsen A, Pump B, Bie P, Chris-tensen NJ, Warberg J, Videbaek R, Simonson SR, Norsk P. Low LBNP tolerance in men is associated with attenuated activation of the renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 279: R822-R829, 2000.
19. Hanson JM, Van Hoeyweghen R, Kirkman E, Thomas A, Horan MA. Use of stroke distance in the early detection of simulated blood loss. J Trauma 44: 128-134, 1998.
20. Hinojosa-Laborde C, Rickards CA, Ryan KL, Convertino VA. Heart rate variability during simulated hemorrhage with lower body negative pressure in high and low tolerant subjects. Front Physiol 2: 85, 2011.
21. Hinojosa-Laborde C, Shade RE, Muniz GW, Bauer C, Goei KA, Pidcoke HF, Chung KK, Cap AP, Convertino VA. Validation of lower body negative pressure as an experimental model of hemorrhage. J Appl Physiol 116: 406-415, 2014.
22. Huang SY, Moore LG, McCullough RE, McCullough RG, Micco AJ, Fulco C, Cymerman A, Manco-Johnson M, Weil JV, Reeves JT. Internal carotid and vertebral arterial flow velocity in men at high altitude. J Appl Physiol 63: 395-400, 1987.
23. Jellema WT, Imholz BP, Van Goudoever J, Wesseling KH, Van Lieshout JJ. Finger arterial versus intrabrachial pressure and continuous cardiac output during head-up tilt testing in healthy subjects. Clin Sci (Lond) 91: 193-200, 1996.
24. Jeong SM, Shibata S, Levine BD, Zhang R. Exercise plus volume loading prevents orthostatic intolerance but not reduction in cerebral blood flow velocity after bed rest. Am J Physiol Heart Circ Physiol 302: H489-H497, 2012.
25. Johnson BD, van Helmond N, Curry TB, van Buskirk CM, Conver-tino VA, Joyner MJ. Reductions in central venous pressure by lower body negative pressure or blood loss elicit similar hemodynamic responses. J Appl Physiol 117: 131-141, 2014.
26. Johnson JM, Rowell LB, Niederberger M, Eisman MM. Human splanchnic and forearm vasoconstrictor responses to reductions of right atrial and aortic pressures. Circ Res 34: 515-524, 1974.
27. Julien C. The enigma of Mayer waves: facts and models. Cardiovasc Res 70: 12-21, 2006.
28. Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma 60: S3-S11, 2006.
29. Levine BD, Giller CA, Lane LD, Buckey JC, Blomqvist CG. Cerebral versus systemic hemodynamics during graded orthostatic stress in humans. Circulation 90: 298-306, 1994.
30. Lewis NC, Bain AR, MacLeod DB, Wildfong KW, Smith KJ, Willie CK, Sanders ML, Numan T, Morrison SA, Foster GE, Stewart JM, Ainslie PN. Impact of hypocapnia and cerebral perfusion on orthostatic tolerance. J Physiol 592: 5203-5219, 2014.
31. Lewis NC, Smith KJ, Bain AR, Wildfong KW, Numan T, Ainslie PN. Impact of transient hypotension on regional cerebral blood flow in humans. Clin Sci (Lond) 129: 169-178, 2015.
32. Lucas RA, Pearson J, Schlader ZJ, Crandall CG. Hypercapnia-induced increases in cerebral blood flow do not improve lower body negative pressure tolerance during hyperthermia. Am J Physiol Regul Integr Comp Physiol 305: R604-R609, 2013.
33. Madsen PL, Secher NH. Near-infrared oximetry of the brain. Prog Neurobiol 58: 541-560, 1999.
34. Martin PJ, Evans DH, Naylor AR. Measurement of blood flow velocity in the basal cerebral circulation: advantages of transcranial color-coded sonography over conventional transcranial Doppler. J Clin Ultrasound 23: 21-26, 1995.
35. Murray RH, Thompson LJ, Bowers JA, Albright CD. Hemodynamic effects of graded hypovolemia and vasodepressor syncope induced by lower body negative pressure. Am Heart J 76: 799-811, 1968.
36. Novak V, Novak P, Spies JM, Low PA. Autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 29: 104-111, 1998.
37. Ogoh S, Sato K, Nakahara H, Okazaki K, Subudhi AW, Miyamoto T. Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries. Exp Physiol 98: 692-698, 2013.
38. Pollard V, Prough DS, DeMelo AE, Deyo DJ, Uchida T, Stoddart HF. Validation in volunteers of a near-infrared spectroscope for monitoring brain oxygenation in vivo. Anesth Analg 82: 269-277, 1996.
39. Rea RF, Hamdan M, Clary MP, Randels MJ, Dayton PJ, Strauss RG. Comparison of muscle sympathetic responses to hemorrhage and lower body negative pressure in humans. J Appl Physiol 70: 1401-1405, 1991.
40. Rickards CA, Cohen KD, Bergeron LL, Burton BL, Khatri PJ, Lee CT, Ryan KL, Cooke WH, Doerr DF, Convertino VA. Cerebral blood flow response and its association with symptoms during orthostatic hypotension. Aviat Space Environ Med 78: 653-658, 2007.
41. Rickards CA, Ryan KL, Cooke WH, Convertino VA. Tolerance to central hypovolemia: the influence of oscillations in arterial pressure and cerebral blood velocity. J Appl Physiol 111: 1048-1058, 2011.
42. Ryan KL, Cooke WH, Rickards CA, Lurie KG, Convertino VA. Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans. J Appl Physiol 104: 1402-1409, 2008.
43. Sato K, Fisher JP, Seifert T, Overgaard M, Secher NH, Ogoh S. Blood flow in internal carotid and vertebral arteries during orthostatic stress. Exp Physiol 97: 1272-1280, 2012.
44. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL. MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31: 1672-1678, 2000.
45. Shenkin HA, Cheney RH, Govons SR, Hardy JD, Fletcher AG. On the diagnosis of hemorrhage in man-a study of volunteers bled large amounts. Am J Med Sci 208: 421-436, 1944.
46. Stevens PM, Lamb LE. Effects of lower body negative pressure on the cardiovascular system. Am J Cardiol 16: 506-515, 1965.
47. Summers RL, Ward KR, Witten T, Convertino VA, Ryan KL, Cole-man TG, Hester RL. Validation of a computational platform for the analysis of the physiologic mechanisms of a human experimental model of hemorrhage. Resuscitation 80: 1405-1410, 2009.
48. Torella F, Cowley RD, Thorniley MS, McCollum CN. Regional tissue oxygenation during hemorrhage: can near infrared spectroscopy be used to monitor blood loss? Shock 18: 440-444, 2002.
49. Verbree J, Bronzwaer AS, Ghariq E, Versluis MJ, Daemen MJ, van Buchem MA, Dahan A, Van Lieshout JJ, van Osch MJ. Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra high-field MRI. J Appl Physiol 117: 1084-1089, 2014.
50. Wallace JP, Sharpey-Schafer EP. Blood changes following controlled hemorrhage in man. Lancet 2: 393-395, 1941.
51. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ, Smirl JD, Day TA, Lucas SJ, Eller LK, Ainslie PN. Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neu-rosci Methods 196: 221-237, 2011.
52. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN. Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590: 3261-3275, 2012.
53. Wolthuis RA, Bergman SA, Nicogossian AE. Physiological effects of locally applied reduced pressure in man. Physiol Rev 54: 566-595, 1974.
54. Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol Heart Circ Physiol 274: H233-H241, 1998.
55. Zhang R, Zuckerman JH, Levine BD. Deterioration of cerebral auto-regulation during orthostatic stress: insights from the frequency domain. J Appl Physiol 85: 1113-1122, 1998.