High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: A pilot study

Journal of Applied Physiology

Volumn 119, Issue 6, 2015, Pages 753-758

  Angadi, Siddhartha S ^a,b   Mookadam, Farouk ^b   Lee, Chong D ^a   Tucker, Wesley J ^a   Haykowsky, Mark J ^c   Gaesser, Glenn A ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Diastolic dysfunction; Exercise training; Heart failure with preserved ejection fraction; High intensity interval exercise; Peak oxygen uptake

Indexed keywords

AGED; BRACHIAL ARTERY; CLINICAL TRIAL; DIASTOLE; ECHOCARDIOGRAPHY; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HUMAN; KINESIOTHERAPY; MALE; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY; PROCEDURES;

AGED; BRACHIAL ARTERY; DIASTOLE; ECHOCARDIOGRAPHY; EXERCISE; EXERCISE TEST; EXERCISE THERAPY; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART RATE; HUMANS; MALE; OXYGEN CONSUMPTION; PILOT PROJECTS; VENTRICULAR FUNCTION, LEFT;

EID: 84942244941     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00518.2014     Document Type: Article

References (38)

1. Alves AJ, Ribeiro F, Goldhammer E, Rivlin Y, Rosenschein U, Viana JL, Duarte JA, Sagiv M, Oliveira J. Exercise training improves diastolic function in heart failure patients. Med Sci Sports Exerc 44: 776-785, 2011.
2. Arena R, Myers J, Forman DE, Lavie CJ, Guazzi M. Should high-intensity-aerobic interval training become the clinical standard in heart failure? Heart Fail Rev 18: 95-105, 2013.
3. Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JA, Franklin B, Sanderson B, Southard D. Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee; the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. J Cardio-pulm Rehabil Prev 27: 121-129, 2007.
4. Bhuiyan T, Maurer MS. Heart failure with preserved ejection fraction: persistent diagnosis, therapeutic enigma. Curr Cardiovasc Risk Rep 5: 440-449, 2011.
5. Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation 123: 2006-2013; discussion 2014, 2011.
6. Church TS, Earnest CP, Skinner JS, Blair SN. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA 297: 2081-2091, 2007.
7. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Rout-ledge Academic, 2013.
8. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbon-neau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39: 257-265, 2002.
9. Edelmann F, Gelbrich G, Dungen HD, Frohling S, Wachter R, Stah-renberg R, Binder L, Topper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Loffler M, Hasenfuss G, Halle M, Pieske B. Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol 58: 1780-1791, 2011.
10. Fujimoto N, Prasad A, Hastings JL, Bhella PS, Shibata S, Palmer D, Levine BD. Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction. Am Heart J 164: 869-877, 2012.
11. Gaesser GA, Poole DC. Lactate and ventilatory thresholds: disparity in time course of adaptations to training. J Appl Physiol 61: 999-1004, 1986.
12. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP, American College of Sports Medicine. American College of Sports Medicine Position Stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculosk-eletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43: 1334-1359, 2011.
13. Garcia MJ, Firstenberg MS, Greenberg NL, Smedira N, Rodriguez L, Prior D, Thomas JD. Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans. Am J Physiol Heart Circ Physiol 280: H554-H561, 2001.
14. Gibbons RJ, Balady GJ, Beasley JW, Bricker JT, Duvernoy WFC, Froelicher VF, Mark DB, Marwick TH, McCallister BD, Thompson PD, Winters WL Jr, Yanowitz FG, Ritchie JL, Cheitlin MD, Eagle KA, Gardner TJ, Garson A Jr, Lewis RP, O'Rourke RA, Ryan TJ. ACC/AHA Guidelines for Exercise Testing: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). Circulation 96: 345-354, 1997.
15. Haykowsky MJ, Brubaker PH, Stewart KP, Morgan TM, Eggebeen J, Kitzman DW. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol 60: 120-128, 2012.
16. Haykowsky MJ, Timmons MP, Kruger C, McNeely M, Taylor DA, Clark AM. Meta-analysis of aerobic interval training on exercise capacity and systolic function in patients with heart failure and reduced ejection fractions. Am J Cardiol 111: 1466-1469, 2013.
17. Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG, Konstam MA, Mancini DM, Rahko PS, Silver MA, Stevenson LW, Yancy CW. 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 119: 1977-2016, 2009.
18. Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hu-daihed A, Yasskiy A. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation 111: 310-314, 2005.
19. Keteyian SJ. Exercise training in patients with heart failure and preserved ejection fraction: findings awaiting discovery. J Am Coll Cardiol 62: 593-594, 2013.
20. Kitzman DW. Exercise training in heart failure with preserved ejection fraction: beyond proof-of-concept. J Am Coll Cardiol 58: 1792-1794, 2011.
21. Kitzman DW, Brubaker PH, Herrington DM, Morgan TM, Stewart KP, Hundley WG, Abdelhamed A, Haykowsky MJ. Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol 62: 584-592, 2013.
22. Kitzman DW, Brubaker PH, Morgan TM, Stewart KP, Little WC. Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail 3: 659-667, 2010.
23. Linke A, Schoene N, Gielen S, Hofer J, Erbs S, Schuler G, Hambrecht R. Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. J Am Coll Cardiol 37: 392-397, 2001.
24. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, Hong Y; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119: e21-181, 2009.
25. Malfatto G, Branzi G, Osculati G, Valli P, Cuoccio P, Ciambellotti F, Parati G, Facchini M. Improvement in left ventricular diastolic stiffness induced by physical training in patients with dilated cardiomyopathy. J Cardiac Fail 15: 327-333, 2009.
26. Moholdt TT, Amundsen BH, Rustad LA, Wahba A, Lovo KT, Gul-likstad LR, Bye A, Skogvoll E, Wisloff U, Slordahl SA. Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life. Am Heart J 158: 1031-1037, 2009.
27. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelisa A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 10: 165-193, 2009.
28. Nechwatal RM, Duck C, Gruber G. [Physical training as interval or continuous training in chronic heart failure for improving functional capacity, hemodynamics and quality of life-a controlled study]. Zeitschr Kardiol 91: 328-337, 2002.
29. Pina IL, Apstein CS, Balady GJ, Belardinelli R, Chaitman BR, Duscha BD, Fletcher BJ, Fleg JL, Myers JN, Sullivan MJ. Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation 107: 1210-1225, 2003.
30. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age-and gender-related ventricular-vascular stiffening: a community-based study. Circulation 112: 2254-2262, 2005.
31. Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 289: 194-202, 2003.
32. Sandri M, Kozarez I, Adams V, Mangner N, Höllriegel R, Erbs S, Linke A, Möbius-Winkler S, Thiery J, Kratzsch J, Teupser D, Mende M, Hambrecht R, Schuler G, Gielen S. Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: The Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. Eur Heart J 33: 1758-1768, 2012.
33. Smart NA, Dieberg G, Giallauria F. Intermittent versus continuous exercise training in chronic heart failure: a meta-analysis. Int J Cardiol 166: 352-358, 2013.
34. Smart NA, Haluska B, Jeffriess L, Leung D. Exercise training in heart failure with preserved systolic function: a randomized controlled trial of the effects on cardiac function and functional capacity. Congest Heart Fail 18: 295-301, 2012.
35. Tabet JY, Meurin P, Beauvais F, Weber H, Renaud N, Thabut G, Cohen-Solal A, Logeart D, Ben Driss A. Absence of exercise capacity improvement after exercise training program: a strong prognostic factor in patients with chronic heart failure. Circ Heart Fail 1: 220-226, 2008.
36. Taylor RS, Davies EJ, Dalal HM, Davis R, Doherty P, Cooper C, Holland DJ, Jolly K, Smart NA. Effects of exercise training for heart failure with preserved ejection fraction: a systematic review and meta-analysis of comparative studies. Int J Cardiol 162: 6-13, 2012.
37. Tinken TM, Thijssen DH, Black MA, Cable NT, Green DJ. Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol 586: 5003-5012, 2008.
38. Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115: 3086-3094, 2007.