Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Yamamoto, Suguru ^a   Kazama, Junichiro J ^a,b   Omori, Kentaro ^c   Matsuo, Koji ^a   Takahashi, Yoshimitsu ^a   Kawamura, Kazuko ^a   Matsuto, Takayuki ^a   Watanabe, Hiroshi ^d   Maruyama, Toru ^d   Narita, Ichiei ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^c Omori Clinic ^*  (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4-CRESOL SULFATE; 8-EPI-PROSTAGLANDIN F2ALPHA; AST 120; BIOLOGICAL MARKER; CARBON; CRESOL; INDICAN; OXIDE; PHENYLSULFATE; PROSTAGLANDIN F2 ALPHA; SERUM ALBUMIN; SULFATE; TOXIN;

AGED; ANALOGS AND DERIVATIVES; BLOOD; FEMALE; HEMODIALYSIS; HUMAN; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC; UREMIA;

AGED; BIOMARKERS; CARBON; CRESOLS; DINOPROST; FEMALE; HUMANS; INDICAN; MALE; MIDDLE AGED; OXIDATIVE STRESS; OXIDES; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; SERUM ALBUMIN; SULFURIC ACID ESTERS; TOXINS, BIOLOGICAL; UREMIA;

EID: 84942155533     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14381     Document Type: Article

References (24)

1. Barreto, F. C. et al. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 4, 1551-8 (2009).
2. Bammens, B., Evenepoel, P., Keuleers, H., Verbeke, K. & Vanrenterghem, Y. Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int 69, 1081-7 (2006).
3. Lekawanvijit, S., Kompa, A. R., Wang, B. H., Kelly, D. J. & Krum, H. Cardiorenal syndrome: the emerging role of protein-bound uremic toxins. Circ Res 111, 1470-83 (2012).
4. Susantitaphong, P., Siribamrungwong, M. & Jaber, B. L. Convective therapies versus low-flux hemodialysis for chronic kidney failure: a meta-analysis of randomized controlled trials. Nephrol Dial Transplant 28, 2859-74 (2013).
5. Itoh, Y., Ezawa, A., Kikuchi, K., Tsuruta, Y. & Niwa, T. Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production. Anal Bioanal Chem 403, 1841-50 (2012).
6. Watanabe, H. et al. p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase. Kidney Int 83, 582-92 (2013).
7. Muteliefu, G. et al. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress. Am J Physiol Cell Physiol 303, C126-34 (2012).
8. Schulman, G. et al. A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD. Am J Kidney Dis 47, 565-77 (2006).
9. Dou, L. et al. The cardiovascular effect of the uremic solute indole-3 acetic acid. J Am Soc Nephrol 26, 876-87 (2015).
10. Tumur, Z., Shimizu, H., Enomoto, A., Miyazaki, H. & Niwa, T. Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation. Am J Nephrol 31, 435-41 (2010).
11. Lekawanvijit, S. et al. Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes? Eur Heart J 31, 1771-9 (2010).
12. Eknoyan, G. Et Al. Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis. N Engl J Med 347, 2010-9 (2002).
13. Schulman, G.Et Al. Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD. J Am Soc Nephrol 26, 1732-46 (2015).
14. Niwa, T Phenol and p-cresol accumulated in uremic serum measured by HPLC with fluorescence detection. Clin Chem 39, 108-11 (1993).
15. Schepers, E., Glorieux, G & Vanholder, R. The gut: the forgotten organ in uremia? Blood Purif 29, 130-6 (2010).
16. Niwa, T., Ise, M & Miyazaki, T. Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate. Am J Nephrol 14, 207-12 (1994).
17. Sirich, T L., Plummer, N. S., Gardner, C. D., Hostetter, T. H. & Meyer, T. W. Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients. Clin J Am Soc Nephrol 9, 1603-10 (2014).
18. Aronov, P A. et al. Colonic contribution to uremic solutes. J Am Soc Nephrol 22, 1769-76 (2011).
19. Lee, C. T. et al. Effects of AST-120 on blood concentrations of protein-bound uremic toxins and biomarkers of cardiovascular risk in chronic dialysis patients. Blood Purif 37, 76-83 (2014).
20. Fujii, H. et al. Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress. Nephrol Dial Transplant 24, 2089-95 (2009).
21. Yamamoto, S. et al. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice. Nephrol Dial Transplant 26, 2491-7 (2011).
22. Yu, M., Kim, Y. J. & Kang, D. H. Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin J Am Soc Nephrol 6, 30-9 (2011).
23. Akizawa, T. et al. Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial. Am J Kidney Dis 54, 459-67 (2009).
24. Anraku, M. et al. Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients. Kidney Int 66, 841-8 (2004).