-
2
-
-
57049114832
-
The genetics of the p53 pathway, apoptosis and cancer therapy
-
Vazquez A, Bond EE, Levine AJ, Bond GL. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 2008;7:979-87.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 979-987
-
-
Vazquez, A.1
Bond, E.E.2
Levine, A.J.3
Bond, G.L.4
-
3
-
-
77955363995
-
TP53 mutations in human cancers: Origins, consequences, and clinical use
-
Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2010;2:a001008.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
, pp. a001008
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
4
-
-
0037317840
-
Inhibiting the p53-MDM2 interaction: An important target for cancer therapy
-
Chene P. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat Rev Cancer 2003;3:102-9.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 102-109
-
-
Chene, P.1
-
5
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005;24:2899-908.
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
6
-
-
0027325132
-
OncoproteinMDM2conceals the activation domain of tumour suppressor p53
-
Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. OncoproteinMDM2conceals the activation domain of tumour suppressor p53. Nature 1993;362:857-60.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
7
-
-
10744221485
-
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8.
-
(2004)
In Vivo Activation of the p53 Pathway by Small-molecule Antagonists of MDM2. Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
8
-
-
72549094296
-
An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals
-
Mohammad RM, Wu J, Azmi AS, Aboukameel A, Sosin A, Wu S, et al. An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals. Mol Cancer 2009;8:115.
-
(2009)
Mol Cancer
, vol.8
, pp. 115
-
-
Mohammad, R.M.1
Wu, J.2
Azmi, A.S.3
Aboukameel, A.4
Sosin, A.5
Wu, S.6
-
9
-
-
84876914265
-
MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancermodels
-
Tovar C, Graves B, Packman K, Filipovic Z, Higgins B, Xia M, et al. MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancermodels. Cancer Res 2013;73:2587-97.
-
(2013)
Cancer Res
, vol.73
, pp. 2587-2597
-
-
Tovar, C.1
Graves, B.2
Packman, K.3
Filipovic, Z.4
Higgins, B.5
Xia, M.6
-
10
-
-
84862296171
-
Structure-based design of novel inhibitors of the MDM2-p53 interaction
-
Rew Y, Sun D, Gonzalez-Lopez De Turiso F, Bartberger MD, Beck HP, Canon J, et al. Structure-based design of novel inhibitors of the MDM2-p53 interaction. J Med Chem 2012;55:4936-54.
-
(2012)
J Med Chem
, vol.55
, pp. 4936-4954
-
-
Rew, Y.1
Sun, D.2
Gonzalez-Lopez De Turiso, F.3
Bartberger, M.D.4
Beck, H.P.5
Canon, J.6
-
11
-
-
84880896065
-
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development
-
Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem 2013;56:5979-83.
-
(2013)
J Med Chem
, vol.56
, pp. 5979-5983
-
-
Ding, Q.1
Zhang, Z.2
Liu, J.J.3
Jiang, N.4
Zhang, J.5
Ross, T.M.6
-
12
-
-
84896837973
-
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development
-
Sun D, Li Z, Rew Y, Gribble M, Bartberger MD, Beck HP, et al. Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development. J Med Chem 2014;57: 1454-72.
-
(2014)
J Med Chem
, vol.57
, pp. 1454-1472
-
-
Sun, D.1
Li, Z.2
Rew, Y.3
Gribble, M.4
Bartberger, M.D.5
Beck, H.P.6
-
13
-
-
77955475709
-
Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth
-
Carnahan J, Beltran PJ, Babij C, Le Q, RoseMJ, Vonderfecht S, et al. Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth. Mol Cancer Ther 2010;9:2399-410.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2399-2410
-
-
Carnahan, J.1
Beltran, P.J.2
Babij, C.3
Rose, M.J.4
Le Q5
Vonderfecht, S.6
-
14
-
-
84876147318
-
Inhibitors of the p53/hdm2 proteinprotein interaction-path to the clinic
-
Carry JC, Garcia-Echeverria C. Inhibitors of the p53/hdm2 proteinprotein interaction-path to the clinic. Bioorg Med Chem Lett 2013;23: 2480-5.
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 2480-2485
-
-
Carry, J.C.1
Garcia-Echeverria, C.2
-
15
-
-
84960546096
-
Discovery of CGM097 as a novel Mdm2 inhibitor[abstract]
-
Dec 5-9; San Diego, CA. Abstract nr DDT01-01
-
Masuya K, Furet P, Stutz S, Holzer P, Pissot-Soldmann C, Buschmann N, et al. Discovery of CGM097 as a novel Mdm2 inhibitor[abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Dec 5-9; San Diego, CA. Abstract nr DDT01-01.
-
(2014)
Proceedings of the 105th Annual Meeting of the American Association for Cancer Research
-
-
Masuya, K.1
Furet, P.2
Stutz, S.3
Holzer, P.4
Pissot-Soldmann, C.5
Buschmann, N.6
-
16
-
-
0029821230
-
Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex
-
Poklar N, Pilch DS, Lippard SJ, Redding EA, Dunham SU, Breslauer KJ. Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. Proc Natl Acad Sci U S A 1996;93:7606-11.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 7606-7611
-
-
Poklar, N.1
Pilch, D.S.2
Lippard, S.J.3
Redding, E.A.4
Dunham, S.U.5
Breslauer, K.J.6
-
17
-
-
77954187741
-
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
-
Pommier Y, Leo E, Zhang H, Marchand C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol 2012; 17:421-33.
-
(2012)
Chem Biol
, vol.17
, pp. 421-433
-
-
Pommier, Y.1
Leo, E.2
Zhang, H.3
Marchand, C.4
-
18
-
-
0033552595
-
Regulation of p53 in response to DNA damage
-
Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene 1999;18:7644-55.
-
(1999)
Oncogene
, vol.18
, pp. 7644-7655
-
-
Lakin, N.D.1
Jackson, S.P.2
|