Brain localization and neurotoxicity evaluation of Polysorbate 80-modified chitosan nanoparticles in rats

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Yuan, Zhong Yue ^a   Hu, Yu Lan ^a   Gao, Jian Qing ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN NANOPARTICLE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; HYDROGEN PEROXIDE; POLYSORBATE 80; TRIPOLYPHOSPHATE; CHITOSAN; DRUG CARRIER; FLUORESCENT DYE; NANOPARTICLE; POLYSORBATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BIOACCUMULATION; CEREBELLUM; CONTROLLED STUDY; FRONTAL CORTEX; HISTOLOGY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; PARTICLE SIZE; PROTEIN EXPRESSION; RAT; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; BRAIN; CHEMISTRY; DRUG EFFECTS; FRONTAL LOBE; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BODY WEIGHT; BRAIN; CHITOSAN; DRUG CARRIERS; FLUORESCENT DYES; FRONTAL LOBE; IMMUNOHISTOCHEMISTRY; MALE; MICE; NANOPARTICLES; OXIDATIVE STRESS; PARTICLE SIZE; POLYSORBATES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84941991996     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134722     Document Type: Article

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