Chitosan nanoparticles cause pre- and postimplantation embryo complications in mice

Biology of Reproduction

Volumn 88, Issue 4, 2013, Pages

  Park, Mi Ryung ^a   Gurunathan, Sangiliyand ^a   Choi, Yun Jung ^a   Kwon, Deug Nam ^a   Han, Jae Woong ^a   Cho, Ssang Goo ^a   Park, Chankyu ^a   Seo, Han Geuk ^a   Kim, Jin Hoi ^a  

^a Konkuk University   (South Korea)

Author keywords

Apoptosis; Caspases; Chitosan nanoparticles; Implantation; Mouse blastocysts

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 9; CHITOSAN; KRUPPEL LIKE FACTOR 4; NANOPARTICLE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR SOX2; WNT3A PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BLASTOCYST; CELL COUNT; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; FEMALE; FETUS; GENE EXPRESSION; IN VITRO STUDY; INNER CELL MASS; MALE; MORULA; MOUSE; NIDATION; NONHUMAN; PARTICLE SIZE; PREGNANCY OUTCOME; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ABORTION, SPONTANEOUS; ANIMALS; BLASTOCYST; CELL PROLIFERATION; CHITOSAN; EMBRYO TRANSFER; EMBRYONIC DEVELOPMENT; FEMALE; MICE; MICE, INBRED ICR; NANOPARTICLES; PREGNANCY;

MUS;

EID: 84877075625     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.112.107532     Document Type: Article

References (53)

1. Donaldson K. Resolving the nanoparticles paradox. Nanomedicine (Lond) 2006; 1:229-234.
2. Kagan VE, Bayir H, Shvedova AA. Nanomedicine and nanotoxicology: two sides of the same coin. Nanomedicine 2005; 1:313-316.
3. Linkov I, Satterstrom FK, Corey LM. Nanotoxicology and nanomedicine: making hard decisions. Nanomedicine 2008; 4:167-171.
4. Medina C, Santos-Martinez MJ, Radomski A, Corrigan OI, Radomski MW. Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 2007; 150:552-558.
5. Li Q, Dunn ET, Grandmasion EW, Goosen MFA. Applications and properties of chitosan. In: Goosen MFA (ed.), Applications of Chitin and Chitosan. Lancaster: Technomic Publishing Company; 1992:3-29.
6. Kumar MNV. A review of chitin and chitosan applications. React Funct Polym 2000; 46:1-27.
7. Richardson SCW, Kolbe HVJ, Duncan R. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int J Pharm 1999; 178:231-243.
8. Janes KA, Calvo P, Alonso MJ. Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Deliv Rev 2001; 47:83-97.
9. Mislick KA, Baldeschwieler JD. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc Natl Acad Sci 1996; 93:12349-12354.
10. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55:329-347.
11. Ernst E, Pittler M. Chitosan as a treatment for body weight reduction? A meta-analysis. Perfusion 1998; 11:461-465.
12. Gades MD, Stern JS. Chitosan supplementation does not affect fat absorption in healthy males fed a high fat diet, a pilot study. Int J Obes Relat Metab Disord 2002; 26:119-122.
13. Gades MD, Stern JS. Chitosan supplementation and fat absorption in men and women. J Am Diet Assoc 2005; 105:72-77.
14. Choi HG, Kim JK, Kwak DH, Cho JR, Kim JY, Kim BJ, Jung KY, Choi BK, Shin MK, Choo YK. Effects of high molecular weight water-soluble chitosan on in vitro fertilization and ovulation in mice fed a high-fat diet. Arch Pharm Res 2002; 25:178-183.
15. Ma Z, Lim LY. Uptake of chitosan and associated insulin in Caco-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles. Pharm Res 2003; 20:1812-1819.
16. Huang M, Khor E, Lim LY. Uptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylation. Pharm Res 2004; 21:344-353.
17. Qi L, Xu Z, Jiang X, Li Y, Wang M. Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles. Bioorg Med Chem Lett 2005; 15:1397-1399.
18. Loh JW, Yeoh G, Saunders M, Lim LY. Uptake and cytotoxicity of chitosan nanoparticles in human liver cells. Toxicol Appl Pharmacol 2010; 249:148-157.
19. Huiying L, Juan L, Xuan C. Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells. Biomed Pharmacother 2010; 64:521-526.
20. Luo H, Su H, Wang X, Wang L, Li J. N-Succinyl-chitosan nanoparticles induced mitochondria-dependent apoptosis in K562. Mol Cell Probes 2012; 26:164-169.
21. Hu YL, Qi W, Han F, Shao JZ, Gao JQ. Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model. Int J Nanomed 2011; 6:3351-3359.
22. Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol 2011; 6:321-328.
23. Schipper NG, Varum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs. 1: influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm Res 1996; 13:1686-92.
24. Schipper NG, Olsson S, Hoogstraate JA, deBoer AG, Va°rum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res 1997; 14:923-929.
25. Schipper NG, Va°rum KM, Stenberg P, Ocklind G, Lennernäs H, Artursson P. Chitosans as absorption enhancers of poorly absorbable drugs. 3: influence of mucus on absorption enhancement. Eur J Pharm Sci 1999; 8:335-43.
26. Gan Q, Wang T, Cochrane C, McCarron P. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids Surf B Biointerfaces 2005; 44:65-73.
27. Kwon DN, Lee SY, Cho SK, Kang SJ, Jang J, Seo H, Song H, Park JY, Lee SY, Cho SK, Kang SJ, Jang JS, Seo HG, Kim JH. Dynamic control of oligosaccharide modification in the mammary gland: linking recombinant human erythropoietin functional analysis of transgenic mouse milkderived hEPO. Transgenic Res 2006; 15:37-55.
28. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25:402-408.
29. Altman J, Bayer SA. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods. J Comp Neurol 1990; 301:365-381.
30. Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006; 311:622-627.
31. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35:495-516.
32. Parks JC, McCallie BR, Janesch AM, Schoolcraft WB, Katz-Jaffe MG. Blastocyst gene expression correlates with implantation potential. Fertil Steril 2011; 95:1367-1372.
33. Kim TH, Park IK, Nah JW, Choi YJ, Cho CS. Galactosylated chitosan/DNA nanoparticles prepared using water-soluble chitosan as a gene carrier. Biomaterials 2004; 25:3783-3792.
34. Cross JC, Werb Z, Fisher SJ. Implantation and the placenta: key pieces of the development puzzle. Science 1994; 266:1508-1518.
35. Kelly SM, Robaire B, Hales BF. Paternal cyclophosphamide treatment causes postimplantation loss via inner cell mass-specific cell death. Teratology 1992; 45:313-318.
36. Ross PJ, Rodriguez RM, Iager AE, Beyhan Z, Wang K, Ragina NP, Yoon SY, Fissore RA, Cibelli JB. Activation of bovine somatic cell nuclear transfer embryos by PLCZ cRNA injection. Reproduction 2009; 137:427-437.
37. Russ AP, Wattler S, Colledge WH, Aparicio SA, Carlton MB, Pearce JJ, Barton SC, Surani MA, Ryan K, Nehls MC, Wilson V, Evans MJ. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature 2000; 404:95-99.
38. Biellmann F, Hulsmeier AJ, Zhou D, Cinelli P, Hennet T. The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo. BMC Dev Biol 2008; 8:109.
39. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr 1999; 31:305-319.
40. Bonneau MJ, Poulin R. Spermine oxidation leads to necrosis with plasma membrane phosphatidylserine redistribution in mouse leukemia cells. Exp Cell Res 2004; 259:23-34.
41. Hardy K. Cell death in the mammalian blastocyst. Mol Hum Reprod 1997; 3:919-925.
42. Hardy K, Stark J, Winston RM. Maintenance of the inner cell mass in human blastocysts from fragmented embryos. Biol Reprod 2003; 68:1165-1169.
43. Byrne AT, Southgate J, Brison DR, Leese HJ. Analysis of apoptosis in the preimplantation bovine embryo using TUNEL. J Reprod Fertil 1999; 117:97-105.
44. Chan AT, Teo PM, Leung TW, Johnson PJ. The role of chemotherapy in the management of nasopharyngeal carcinoma. Cancer 1998; 82:1003-1012.
45. Liu XS, Kim CN, Yang J, Jemmerson R, Wang XD. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996; 86:147-157.
46. Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. Threedimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell 2002; 9:423-432.
47. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91:479-489.
48. Nuñez G, Benedict MA, Hu Y, Inohara N. Caspases: the proteases of the apoptotic pathway. Oncogene 1998; 17:3237-3245.
49. Janicke RU, Sprengart ML, Wati MR, Porter AGJ. Capase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. Biol Chem 1998; 273:9357-9360.
50. Kibschull M, Gellhaus A, Winterhager E. Analogous and unique functions of connexins in mouse and human placental development. Placenta 2008; 29:848-854.
51. Gasperowicz M, Otto F. The notch signalling pathway in the development of the mouse placenta. Placenta 2008; 29:651-659.
52. Tardiff RG, Carson ML, Ginevan ME. Updated weight of evidence for an association between adverse reproductive and developmental effects and exposure to disinfection byproducts. Regul Toxicol Pharmacol 2006; 45:185-205.
53. Wigle DT, Arbucle TE, Turner MC, Bérubé A, Yang Q, Liu S, Krewski D. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev 2008; 11:373-517.