A common polymorphism in the 5’ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

Genes and Development

Volumn 29, Issue 18, 2015, Pages 1891-1896

  Somers, Joanna ^a   Wilson, Lindsay A ^a   Kilday, John Paul ^b   Horvilleur, Emilie ^a   Cannell, Ian G ^a,c   Pöyry, Tuija A A ^a   Cobbold, Laura C ^a   Kondrashov, Alexander ^d   Knight, John R P ^a   Puget, Stéphanie ^e   Grill, Jacques ^f   Grundy, Richard G ^b   Bushell, Martin ^a   Willis, Anne E ^a  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

^f INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

DNA damage repair; ERCC5; Protein synthesis; uORF

Indexed keywords

CISPLATIN; DNA DEPENDENT PROTEIN KINASE; ERCC5 PROTEIN; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; 5' UNTRANSLATED REGION; ANTINEOPLASTIC AGENT; CALCIUM BINDING PROTEIN; CIB1 PROTEIN, HUMAN; DNA BINDING PROTEIN; DNA EXCISION REPAIR PROTEIN ERCC-5; ENDONUCLEASE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

5' UNTRANSLATED REGION; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CISTRON; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA POLYMORPHISM; DNA REPAIR; DRUG RESPONSE; DRUG SENSITIVITY; EPENDYMOMA; FEMALE; GENE EXPRESSION; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NEUROBLASTOMA CELL LINE; OPEN READING FRAME; PHARMACOGENETICS; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TRANSIENT TRANSFECTION; TRANSLATION REGULATION; CELL LINE; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MORTALITY; TUMOR CELL LINE;

5' UNTRANSLATED REGIONS; ANTINEOPLASTIC AGENTS; CALCIUM-BINDING PROTEINS; CELL LINE; CELL LINE, TUMOR; CISPLATIN; DNA DAMAGE; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; ENDONUCLEASES; EPENDYMOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; NUCLEAR PROTEINS; OPEN READING FRAMES; POLYMORPHISM, GENETIC; TRANSCRIPTION FACTORS;

EID: 84941954686     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.261867.115     Document Type: Article

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