Preoperative Autologous Blood Donation: Waning Indications in an Era of Improved Blood Safety

Transfusion Medicine Reviews

Volumn 29, Issue 4, 2015, Pages 268-275

  Vassallo, Ralph ^a   Goldman, Mindy ^b   Germain, Marc ^c   Lozano, Miguel ^d  

^a Blood Systems Incorporated   (United States)

^b CANADIAN BLOOD SERVICES   (Canada)

^c HÉMA QUÉBEC   (Canada)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

Autologous blood transfusion; Blood donors; Patient blood management

Indexed keywords

ANEMIA; BLEEDING; BLOOD AUTOTRANSFUSION; BLOOD DONOR; BLOOD SAFETY; BLOOD SALVAGE; BLOOD STORAGE; CLINICAL EFFECTIVENESS; COST EFFECTIVENESS ANALYSIS; DISEASE ELIMINATION; ERYTHROCYTE; EUROPE; EVIDENCE BASED MEDICINE; HUMAN; HYPOVOLEMIA; NORTH AMERICA; PREOPERATIVE AUTOLOGOUS DONATION; PREOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; RISK REDUCTION; SOUTH AND CENTRAL AMERICA; TREATMENT INDICATION; ADVERSE EFFECTS; COST BENEFIT ANALYSIS; ECONOMICS; PRACTICE GUIDELINE; STANDARDS; SURGERY; TOTAL QUALITY MANAGEMENT; TRENDS;

BLOOD DONORS; BLOOD SAFETY; BLOOD TRANSFUSION, AUTOLOGOUS; COST-BENEFIT ANALYSIS; HUMANS; PRACTICE GUIDELINES AS TOPIC; PREOPERATIVE PERIOD; QUALITY IMPROVEMENT; RISK ASSESSMENT; SURGICAL PROCEDURES, OPERATIVE;

EID: 84941938004     PISSN: 08877963     EISSN: 15329496     Source Type: Journal    
DOI: 10.1016/j.tmrv.2015.04.001     Document Type: Review

References (81)

1. United Nations Secretariat World population ageing, 1950-2050 2002, UN, New York, NY, [Available at: http://www.un.org/esa/population/publications/worldageing19502050/pdf/81chapteriii.pdf. Last accessed 4/27/15].
2. Brecher M.E., Goodnough L.T. The rise and fall of preoperative autologous blood donation. Transfusion 2002, 42:1618-1622.
3. Goodnough L.T., Shander A. Patient blood management. Anesthesiology 2012, 116:1367-1376.
4. Hébert P.C., Wells G., Blajchman M.A., Marshall J., Martin C., Pagliarello G., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999, 340:409-417.
5. Lacroix J., Hébert P.C., Hutchison J.S., Hume H.A., Tucci M., Ducruet T., et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007, 356:1609-1619.
6. Carson J.L., Terrin M.L., Noveck H., Sanders D.W., Chaitman B.R., Rhoads G.G., et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011, 365:2453-2462.
7. Villanueva C., Colomo A., Bosch A., Concepción M., Hernandez-Gea V., Aracil C., et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013, 368:11-21.
8. Department of Health and Human Services The 2011 national blood collection and utilization survey report 2013, DHHS, Washington, DC, [Available at: http://www.hhs.gov/ash/bloodsafety/2011-nbcus.pdf. Last accessed 4/27/15].
9. Trends and observations on the collection testing and use of blood and blood components in Europe: 2001-2008 report Available at:, [Last accessed 4/27/15]. http://www.edqm.eu/site/trends_and_observations_on_the_collection_testing_and_use_of_blood_and_blood_components_in_europepdf-en-31358-2.html.
10. Supply of blood for transfusion in Latin American and Caribbean countries, 2010 and 2011 Available at:, [Last accessed 4/27/15]. http://www.paho.org/hq/index.php?option=com_content&view=article&id=8917%3Asupply-of-blood-2010-11&catid=3316%3Ahss-0101-publishing&Itemid=3562&lang=en.
11. Zou S., Stramer S.L., Dodd R.Y. Donor testing and risk: current prevalence, incidence, and residual risk of transfusion-transmissible agents in US allogeneic donations. Transfus Med Rev 2012, 26:119-128.
12. Stramer S.L., Notari E.P., Krysztof D.E., Dodd R.Y. Hepatitis B virus testing by minipool nucleic acid testing: does it improve blood safety?. Transfusion 2013, 53:2449-2458.
13. O'Brien S.F., Yi Q.L., Fan W., Scalia V., Fearon M.A., Allain J.P. Current incidence and residual risk of HIV, HBV and HCV at Canadian Blood Services. Vox Sang 2012, 103:83-86.
14. Velati C., Romano L., Fomiatti L., Baruffi L., Zanetti A.R. Impact of nucleic acid testing for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus on the safety of the blood supply in Italy: a 6-year survey. Transfusion 2008, 48:2205-2213.
15. Lozano M. Pathogen-inactivation technologies for blood components. Blood component preparation: from benchtop to bedside 2011, 247-270. AABB Press, Bethesda, Maryland. M. Blajchman, J. Cid, M. Lozano (Eds.).
16. Lee S.J., Liljas B., Churchill W.H., Popovsky M.A., Stowell C.P., Cannon M.E., et al. Perceptions and preferences of autologous blood donors. Transfusion 1998, 38:757-763.
17. Vamvakas E.C., Blajchman M.A. Transfusion-related immunomodulation (TRIM): an update. Blood Rev 2007, 21:327-348.
18. Domen R.E. Adverse reactions associated with autologous blood transfusion: evaluation and incidence at a large academic hospital. Transfusion 1998, 38:296-300.
19. Vamvakas E.C. Meta-analysis of randomized controlled trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion. Vox Sang 2002, 83:339-346.
20. Etchason J., Petz L., Keeler E., Calhoun L., Kleinman S., Snider C., et al. The cost effectiveness of preoperative autologous blood donations. N Engl J Med 1995, 332:719-724.
21. Hernández J.M., Cid J., Claparols M., Mallafré E., Pla R. Infectious disease markers in autologous blood donors and first-time volunteer blood donors: 14 years' experience in a blood center. Haematologica 2004, 89:889-891.
22. Shulman I.A., Osby M. Storage and transfusion of infected autologous blood or components: a survey of North American laboratories. Arch Pathol Lab Med 2005, 129:981-983.
23. Shulman I.A. 1992 CAP Surveys: Comprehensive Transfusion Medicine Survey, 1992 Set J-C. Northfield, Ill: Interlaboratory Comparison Program, College of American Pathologists 1992.
24. Goldman M., Rémy-Prince S., Trépanier A., Décary F. Autologous donation error rates in Canada. Transfusion 1997, 37:523-527.
25. Brooks J.P., Ferrell J.E. Legal and ethical considerations in the transfusion of infected or untested autologous blood. Am J Clin Pathol 2007, 128:135-142.
26. Shulman-Cutler S. The AABB's autologous blood donation suggested guidance: autologous blood, HIV, and the Americans with Disabilities Act. Jurimetrics J 2006, 46:407-419.
27. Cochrane Database Syst Rev 2001, (4):CD003602. 10.1002/14651858.CD003602.
28. Singbartl G., Held A.L., Singbartl K. Ranking the effectiveness of autologous blood conservation measures through validated modeling of independent clinical data. Transfusion 2013, 53:3060-3079.
29. Leal-Noval S.R., Muñoz M., Asuero M., Contreras E., García-Erce J.A., Llau J.V., et al. Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the "Seville Document.". Blood Transfus 2013, 11:585-610. Spanish Expert Panel on Alternatives to Allogeneic Blood Transfusion.
30. Thomas M.J., Gillon J., Desmond M.J. Consensus conference on autologous transfusion. Preoperative autologous donation. Transfusion 1996, 36:633-639.
31. Billote D.B., Glisson S.N., Green D., Wixson R.L. A prospective, randomized study of preoperative autologous donation for hip replacement surgery. J Bone Joint Surg Am 2002, 84-A:1299-1304.
32. Boettner F., Altneu E.I., Williams B.A., Hepinstall M., Sculco T.P. Nonanemic patients do not benefit from autologous blood donation before total hip replacement. HSS J 2010, 6:66-70.
33. Müller U., Röder C., Pisan M., Orler R., El-Kerdi A., Eggli S. Autologous blood donation in total knee arthroplasties is not necessary. Acta Orthop Scand 2004, 75:66-70.
34. Franchini M., Regis D., Gandini G., Corallo F., de Gironcoli M., Aprili G. Preoperative autologous blood donation in primary total knee arthroplasty: a single-centre experience on 214 consecutive patients. Vox Sang 2006, 90:191-194.
35. Regis D., Corallo F., Franchini M., Rosa R., Ricci M., Bartolozzi P. Preoperative autologous blood donation in primary total knee arthroplasty: critical review of current indications. Chir Organi Mov 2008, 91:41-44.
36. Kim S., Altneu E., Monsef J.B., King E.A., Sculco T.P., Boettner F. Nonanemic patients do not benefit from autologous blood donation before total knee replacement. HSS J 2001, 7:141-144.
37. Bou Monsef J., Buckup J., Mayman D., Marx R., Ranawat A., Boettner F. Targeted preoperative autologous blood donation in total knee arthroplasty reduces the need for postoperative transfusion. HSS J 2013, 9:214-217.
38. Muñoz M., García-Erce J.A. Preoperative autologous blood donation in lower limb arthroplasty surgery: has the time come for its retirement?. Blood Transfus 2013, 11:333-336.
39. Perazzo P., Viganò M., De Girolamo L., Verde F., Vinci A., Banfi G., et al. Blood management and transfusion strategies in 600 patients undergoing total joint arthroplasty: an analysis of pre-operative autologous blood donation. Blood Transfus 2013, 11:370-376.
40. Bou Monsef J., Buckup J., Waldstein W., Cornell C., Boettner F. Fibrin sealants or cell saver eliminate the need for autologous blood donation in anemic patients undergoing primary total knee arthroplasty. Arch Orthop Trauma Surg 2014, 134:53-58.
41. Jakovina Blazekovic S., Bicanic G., Hrabac P., Tripkovic B., Delimar D. Pre-operative autologous blood donation versus no blood donation in total knee arthroplasty: a prospective randomised trial. Int Orthop 2014, 38:341-346.
42. Cha C.W., Deible C., Muzzonigro T., Lopez-Plaza I., Vogt M., Kang J.D. Allogeneic transfusion requirements after autologous donations in posterior lumbar surgeries. Spine 2002, 27:99-104.
43. Kennedy C., Leonard M., Devitt A., Girardi F.P., Cammisa F.P. Efficacy of preoperative autologous blood donation for elective posterior lumbar spinal surgery. Spine 2011, 36:E1736-E1743.
44. Vega S.J., Nguyen T.V., Forsberg C., Hua L.B., Kirkley S.A., Herrera H.R., et al. Efficacy of preoperative autologous blood donation in free TRAM flap breast reconstruction. Plast Reconstr Surg 2008, 121:241e-246e.
45. Louer C.R., Chang J.B., Hollenbeck S.T., Zenn M.R. Autologous blood use for free flap breast reconstruction: a comparative evaluation of a preoperative blood donation program. Ann Plast Surg 2013, 70:158-161.
46. Park J.O., Gonen M., D'Angelica M.I., DeMatteo R.P., Fong Y., Wuest D., et al. Autologous versus allogeneic transfusions: no difference in perioperative outcome after partial hepatectomy. Autologous transfusion on hepatectomy outcome. J Gastrointest Surg 2007, 11:1286-1293.
47. Mijovic A., Britten C., Regan F., Harrison J. Preoperative autologous blood donation for bone marrow harvests: are we wasting donors' time and blood?. Transfus Med 2006, 16:57-62.
48. Böttger S., Streckbein P., Hartmann B., Schaaf H., Howaldt H.P., Junger A. Retrospective analysis of autologous blood use in bimaxillary repositioning osteotomy surgery: a quality improvement study. Transfusion 2009, 49:1747-1753.
49. British Committee for Standards in Haematology Transfusion Task Force, Boulton F.E., James V. Guidelines for policies on alternatives to allogeneic blood transfusion. 1. Predeposit autologous blood donation and transfusion. Transfus Med 2007, 17:354-365.
50. Available at:, [Last accessed 2/23/15]. http://www.sanquin.nl/repository/documenten/en/prod-en-dienst/287294/blood-transfusion-guideline.pdf.
51. Lawrence V.A., Silverstein J.H., Cornell J.E., Pederson T., Noveck H., Carson J.L. Higher Hb level is associated with better early functional recovery after hip fracture repair. Transfusion 2004, 43:1717-1722.
52. Ranucci M., La Rovere M.T., Castelvecchio S., Maestri R., Menicanti L., Frigiola A., et al. Postoperative anemia and exercise tolerance after cardiac operations in patients without transfusion: what hemoglobin level is acceptable?. Ann Thorac Surg 2011, 92:25-31.
53. Pilot P., Bols E.M., Verburg A.D., Bell C.A., Moonen A.F., van Os J.J., et al. The use of autologous blood to improve exercise capacity after total hip arthroplasty: a preliminary report. Transfusion 2006, 46:1484-1490.
54. Conlon N.P., Bale E.P., Herbison G.P., McCarroll M. Postoperative anemia and quality of life after primary hip arthroplasty in patients over 65 years old. Anest Analg 2008, 106:1056-1061.
55. Schremp P.S., Jeffrey J.E., Paskert K.M., Roberts B.L. Clinical implications of the impact of autologous blood donation on functional recovery. Orthop Nurs 1991, 10:33-37.
56. Halm E.A., Wang J.J., Boockvar K., Penrod J., Silberzweig S.B., Magaziner J., et al. Effects of blood transfusion on clinical and functional outcomes in patients with hip fracture. Transfusion 2003, 43:1358-1365.
57. Halm E.A., Wang J.J., Boockvar K., Penrod J., Silberzweig S.B., Magaziner J., et al. The effect of perioperative anemia on clinical and functional outcomes in patients with hip fracture. J Orthop Trauma 2004, 18:369-374.
58. So-Osman C., Nelissen R., Te Slaa R., Coene L., Brand R., Brand A. A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cells. Vox Sang 2010, 98:56-64.
59. So-Osman C., Nelissen R., Brand R., Brand A., Stiggelbout A.M. Postoperative anemia after joint replacement surgery is not related to quality of life during the first two weeks postoperatively. Transfusion 2011, 51:71-81.
60. Vuille-Lessard E., Boudreault D., Girard F., Ruel M., Chagnon M., Hardy J.F. Postoperative anemia does not impede functional outcome and quality of life early after hip and knee arthroplasties. Transfusion 2012, 52:261-270.
61. Foss N.B., Kristensen M.T., Jensen P.S., Palm H., Krasheninnikoff M., Kehlet H. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion 2009, 49:227-234.
62. Standards for blood banks and transfusion services 2014, 19. AABB Press, Bethesda, MD. 29th ed.
63. Pottgiesser T., Specker W., Umhau M., Dickhuth H.H., Roecker K., Schumacher Y.O. Recovery of hemoglobin mass after blood donation. Transfusion 2008, 48:1390-1397.
64. Kiss J.E., Brambilla D., Simone G.A., Mast A.E., Spencer B.R., Stone M., et al. Oral iron supplementation after blood donation: a randomized clinical trial. JAMA 2015, 313:575-583.
65. Singbartl G. Preoperative autologous blood donation-part I. Only two clinical parameters determine efficacy of the autologous predeposit. Minerva Anestesiol 2007, 73:143-151.
66. Singbartl G., Malgorzata S., Quoss A. Preoperative autologous blood donation-part II. Adapting the predeposit concept to the physiological basics of erythropoiesis improves its efficacy. Minerva Anestesiol 2007, 73:153-160.
67. Singbartl G. Pre-operative autologous blood donation: clinical parameters and efficacy. Blood Transfus 2011, 9:10-18.
68. Kim M., Kim H.S., Kim Y.H., Choi J.S., Yang H.J., Hwang S.J., et al. Comparison of whole blood collection and double-unit erythrocytapheresis in preoperative autologous blood donation. Transfus Apher Sci 2013, 49:542-547.
69. Singbartl G., Schreiber J., Singbartl K. Preoperative autologous blood donation versus intraoperative blood salvage: intraindividual analyses and modeling of efficacy in 1103 patients. Transfusion 2009, 49:2374-2383.
70. Popovsky M.A., Whitaker B., Arnold N.L. Severe outcomes of allogeneic and autologous blood donation: frequency and characterization. Transfusion 1995, 35:734-737.
71. AuBuchon J.P., Popovsky M.A. The safety of preoperative autologous blood donation in the nonhospital setting. Transfusion 1991, 31:513-517.
72. McVay P.A., Andrews A., Hoag M.S., Polan D., Skettino S., Stehling L.C., et al. Moderate and severe reactions during autologous blood donations are no more frequent than during homologous blood donations. Vox Sang 1990, 59:70-72.
73. McVay P.A., Andrews A., Kaplan E.B., Black D.B., Stehling L.C., Strauss R.G., et al. Donation reactions amongst autologous donors. Transfusion 1990, 30:249-253.
74. Eder A.F., Notari E.P., Dodd R.Y. Do reactions after whole blood donation predict syncope on return donation?. Transfusion 2012, 52:2570-2576.
75. NHTSA Traffic Safety Facts, November 2013-2012 Motor Vehicle Crashes: Overview Available at:, [Last accessed 4/27/15]. http://www-nrd.nhtsa.dot.gov/Pubs/811856.pdf.
76. Birkmeyer J.D., Goodnough L.T., AuBuchon J.P., Noordsij P.G., Littenberg B. The cost-effectiveness of preoperative autologous blood donation for total hip and knee replacement. Transfusion 1993, 33:544-551.
77. Birkmeyer J.D., AuBuchon J.P., Littenberg B., O'Connor G.T., Nease R.F., Nugent W.C., et al. Cost-effectiveness of preoperative autologous donation in coronary artery bypass grafting. Ann Thorac Surg 1994, 57:161-169.
78. Marchetti M., Barosi G. Cost-effectiveness of epoetin and autologous blood donation in reducing allogeneic blood transfusions in coronary artery bypass graft surgery. Transfusion 2002, 40:673-681.
79. Goodnough L.M., Grishaber J.E., Birkmeyer J.D., Monk T.G., Catalona W.J. Efficacy and cost-effectiveness of autologous blood predeposit in patients undergoing radical prostatectomy procedures. Urology 1994, 44:226-231.
80. Horowitz N.S., Gibb R.K., Menegakis N.E., Mutch D.G., Rader J.S., Herzog T.J. Utility and cost-effectiveness of preoperative autologous blood donation in gynecologic and gynecologic oncology patients. Obstet Gynecol 2002, 99:771-779.
81. Available at:, [Last accessed 4/27/15]. https://www.cia.gov/library/publications/the-world-factbook/rankorder/2004rank.html.