Investigation of Neuropathogenesis in HIV-1 Clade B and C Infection Associated with IL-33 and ST2 Regulation

ACS Chemical Neuroscience

Volumn 6, Issue 9, 2015, Pages 1600-1612

  Yndart, Adriana ^a   Kaushik, Ajeet ^a   Agudelo, Marisela ^a   Raymond, Andrea ^a   Atluri, Venkata S ^a   Saxena, Shailendra K ^b   Nair, Madhavan ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

clade B; clade C; HIV 1; IL 33; neuroAIDS; Neuroinflammation; ST2; synaptic plasticity

Indexed keywords

CASPASE 3; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 33; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2C; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; ST2 PROTEIN; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; IL1RL1 PROTEIN, HUMAN; IL33 PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR LIKE 1 PROTEIN; MEF2C PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ADAPTIVE IMMUNITY; APOPTOSIS; ARTICLE; CENTRAL NERVOUS SYSTEM; CLADISTICS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE B; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE C; IMMUNE RESPONSE; IMMUNOMODULATION; INNATE IMMUNITY; MICROGLIA; NERVE CELL PLASTICITY; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; WESTERN BLOTTING; ASTROCYTE; CELL CULTURE; CLASSIFICATION; COMPARATIVE STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; UPREGULATION;

APOPTOSIS; ASTROCYTES; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; INTERLEUKIN-1 RECEPTOR-LIKE 1 PROTEIN; INTERLEUKIN-33; MEF2 TRANSCRIPTION FACTORS; NEUROIMMUNOMODULATION; NEURONAL PLASTICITY; NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; UP-REGULATION;

EID: 84941899243     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00156     Document Type: Article

References (41)

1. Gandhi, N., Saiyed, Z., Thangavel, S., Rodriguez, J., Rao, K. V., and Nair, M. P. (2009) Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes AIDS Res. Hum. Retroviruses 25 (7) 691-9 10.1089/aid.2008.0299
2. Samikkannu, T., Rao, K. V., Kanthikeel, S. P., Atluri, V. S. R., Agudelo, M., Roy, U., and Nair, M. P. (2014) Immunoneuropathogenesis of HIV-1 clades B and C: Role of redox expression and thiol modification Free Radical Biol. Med. 69, 136-144 10.1016/j.freeradbiomed.2013.12.025
3. Riedel, D., Ghate, M., Nene, M., Paranjape, R., Mehendale, S., Bollinger, R., Sacktor, N., McArthur, J., and Nath, A. (2006) Screening for human immunodeficiency virus (HIV) dementia in an HIV clade C-infected population in India J. NeuroVirol. 12 (1) 34-8 10.1080/13550280500516500
4. Satishchandra, P., Nalini, A., Gourie-Devi, M., Khanna, N., Santosh, V., Ravi, V., Desai, A., Chandramuki, A., Jayakumar, P. N., and Shankar, S. K. (2000) Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96) Indian J. Med. Res. 111, 14-23
5. Abecasis, A., Wensing, A., Paraskevis, D., Vercauteren, J., Theys, K., Van de Vijver, D., Albert, J., Asjo, B., Balotta, C., Beshkov, D., Camacho, R., Clotet, B., De Gascun, C., Griskevicius, A., Grossman, Z., Hamouda, O., Horban, A., Kolupajeva, T., Korn, K., Kostrikis, L., Kucherer, C., Liitsola, K., Linka, M., Nielsen, C., Otelea, D., Paredes, R., Poljak, M., Puchhammer-Stockl, E., Schmit, J.-C., Sonnerborg, A., Stanekova, D., Stanojevic, M., Struck, D., Boucher, C., and Vandamme, A.-M. (2013) HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics Retrovirology 10 (1) 7 10.1186/1742-4690-10-7
6. Power, C., Gill, M. J., and Johnson, R. T. (2002) Progress in clinical neurosciences: The neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy Can. J. Neurol. Sci. 29 (1) 19-32 10.1017/S0317167100001682
7. Carriere, V., Roussel, L., Ortega, N., Lacorre, D. A., Americh, L., Aguilar, L., Bouche, G., and Girard, J. P. (2007) IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo Proc. Natl. Acad. Sci. U. S. A. 104 (1) 282-7 10.1073/pnas.0606854104
8. Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., Gorman, D. M., Bazan, J. F., and Kastelein, R. A. (2005) IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines Immunity 23 (5) 479-490 10.1016/j.immuni.2005.09.015
9. Le Goffic, R., Arshad, M. I., Rauch, M., L'Helgoualc'h, A., Delmas, B., Piquet-Pellorce, C., and Samson, M. (2011) Infection with influenza virus induces IL-33 in murine lungs Am. J. Respir. Cell Mol. Biol. 45 (6) 1125-1132 10.1165/rcmb.2010-0516OC
10. Hayakawa, H., Hayakawa, M., Kume, A., and Tominaga, S. (2007) Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation J. Biol. Chem. 282 (36) 26369-80 10.1074/jbc.M704916200
11. Miller, A. (2011) Role of IL-33 in inflammation and disease J. Inflammation 8 (1) 22 10.1186/1476-9255-8-22
12. Hudson, C. A., Christophi, G. P., Gruber, R. C., Wilmore, J. R., Lawrence, D. A., and Massa, P. T. (2008) Induction of IL-33 expression and activity in central nervous system glia J. Leukocyte Biol. 84 (3) 631-43 10.1189/jlb.1207830
13. Yasuoka, S., Kawanokuchi, J., Parajuli, B., Jin, S., Doi, Y., Noda, M., Sonobe, Y., Takeuchi, H., Mizuno, T., and Suzumura, A. (2011) Production and functions of IL-33 in the central nervous system Brain Res. 1385, 8-17 10.1016/j.brainres.2011.02.045
14. Smith, J. A., Das, A., Ray, S. K., and Banik, N. L. (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases Brain Res. Bull. 87 (1) 10-20 10.1016/j.brainresbull.2011.10.004
15. Atluri, V. S., Kanthikeel, S. P., Reddy, P. V., Yndart, A., and Nair, M. P. (2013) Human synaptic plasticity gene expression profile and dendritic spine density changes in HIV-infected human CNS cells: role in HIV-associated neurocognitive disorders (HAND) PLoS One 8 (4) e61399 10.1371/journal.pone.0061399
16. Albensi, B. C. and Mattson, M. P. (2000) Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity Synapse 35 (2) 151-159 10.1002/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.3.CO;2-G
17. Barrientos, R. M., O'Reilly, R. C., and Rudy, J. W. (2002) Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration Behav. Brain Res. 134 (1-2) 299-306 10.1016/S0166-4328(02)00045-1
18. Di Filippo, M., Chiasserini, D., Gardoni, F., Viviani, B., Tozzi, A., Giampa, C., Costa, C., Tantucci, M., Zianni, E., Boraso, M., Siliquini, S., de Iure, A., Ghiglieri, V., Colcelli, E., Baker, D., Sarchielli, P., Fusco, F. R., Di Luca, M., and Calabresi, P. (2013) Effects of central and peripheral inflammation on hippocampal synaptic plasticity Neurobiol. Dis. 52, 229-36 10.1016/j.nbd.2012.12.009
19. Di Filippo, M., Sarchielli, P., Picconi, B., and Calabresi, P. (2008) Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders Trends Pharmacol. Sci. 29 (8) 402-12 10.1016/j.tips.2008.06.005
20. Khairova, R. A., Machado-Vieira, R., Du, J., and Manji, H. K. (2009) A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder Int. J. Neuropsychopharmacol. 12 (4) 561-78 10.1017/S1461145709009924
21. Kim, Y. K., Na, K. S., Shin, K. H., Jung, H. Y., Choi, S. H., and Kim, J. B. (2007) Cytokine imbalance in the pathophysiology of major depressive disorder Prog. Neuro-Psychopharmacol. Biol. Psychiatry 31 (5) 1044-53 10.1016/j.pnpbp.2007.03.004
22. Rao, V. R., Sas, A. R., Eugenin, E. A., Siddappa, N. B., Bimonte-Nelson, H., Berman, J. W., Ranga, U., Tyor, W. R., and Prasad, V. R. (2008) HIV-1 clade-specific differences in the induction of neuropathogenesis J. Neurosci. 28 (40) 10010-6 10.1523/JNEUROSCI.2955-08.2008
23. White, D. A., Heaton, R. K., and Monsch, A. U. (1995) Neuropsychological studies of asymptomatic human immunodeficiency virus-type-1 infected individuals. The HNRC Group. HIV Neurobehavioral Research Center J. Int. Neuropsychol. Soc. 1 (3) 304-15 10.1017/S1355617700000308
24. Tyor, W., Fritz-French, C., and Nath, A. (2013) Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders J. NeuroVirol. 19 (6) 515-22 10.1007/s13365-013-0206-6
25. Tajima, S., Oshikawa, K., Tominaga, S.-i., and Sugiyama, Y. (2003) THe increase in serum soluble st2 protein upon acute exacerbation of idiopathic pulmonary fibrosis∗ Chest 124 (4) 1206-1214 10.1378/chest.124.4.1206
26. Akhtar, M. W., Kim, M. S., Adachi, M., Morris, M. J., Qi, X., Richardson, J. A., Bassel-Duby, R., Olson, E. N., Kavalali, E. T., and Monteggia, L. M. (2012) In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival PLoS One 7 (4) e34863 10.1371/journal.pone.0034863
27. Li, H., Radford, J. C., Ragusa, M. J., Shea, K. L., McKercher, S. R., Zaremba, J. D., Soussou, W., Nie, Z., Kang, Y. J., Nakanishi, N., Okamoto, S., Roberts, A. J., Schwarz, J. J., and Lipton, S. A. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo Proc. Natl. Acad. Sci. U. S. A. 105 (27) 9397-402 10.1073/pnas.0802876105
28. Miyagaki, T., Sugaya, M., Yokobayashi, H., Kato, T., Ohmatsu, H., Fujita, H., Saeki, H., Kikuchi, Y., Tamaki, T., and Sato, S. (2011) High levels of soluble ST2 and low levels of IL-33 in sera of patients with HIV infection J. Invest. Dermatol. 131 (3) 794-6 10.1038/jid.2010.366
29. Lu, J., McKinsey, T. A., Nicol, R. L., and Olson, E. N. (2000) Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases Proc. Natl. Acad. Sci. U. S. A. 97 (8) 4070-4075 10.1073/pnas.080064097
30. Xu, Z., Yoshida, T., Wu, L., Maiti, D., Cebotaru, L., and Duh, E. J. (2014) Transcription Factor MEF2C Suppresses Endothelial Cell Inflammation via Regulation of NF†ΰB and KLF2 J. Cell. Physiol. 230, 1310 10.1002/jcp.24870
31. Yin, Y., She, H., Li, W., Yang, Q., Guo, S., and Mao, Z. (2012) Modulation of neuronal survival factor MEF2 by kinases in Parkinsonâ€s disease Front. Physiol. 3, 171 10.3389/fphys.2012.00171
32. McNamee, J. P., Bellier, P. V., Kutzner, B. C., and Wilkins, R. C. (2005) Effect of pro-inflammatory cytokines on spontaneous apoptosis in leukocyte sub-sets within a whole blood culture Cytokine+ 31 (2) 161-167 10.1016/j.cyto.2005.05.001
33. Alvarez, S., Blanco, A., Fresno, M., and Munoz-Fernandez, M. A. (2011) TNF-alpha contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT PLoS One 6 (1) e16100 10.1371/journal.pone.0016100
34. Ohagen, A., Ghosh, S., He, J., Huang, K., Chen, Y., Yuan, M., Osathanondh, R., Gartner, S., Shi, B., Shaw, G., and Gabuzda, D. (1999) Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope J. Virol 73 (2) 897-906
35. Tamrakar, A. K., Schertzer, J. D., Chiu, T. T., Foley, K. P., Bilan, P. J., Philpott, D. J., and Klip, A. (2010) NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance Endocrinology 151 (12) 5624-37 10.1210/en.2010-0437
36. Ogura, Y., Inohara, N., Benito, A., Chen, F. F., Yamaoka, S., and Nunez, G. (2001) Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-kB J. Biol. Chem. 276 (7) 4812-4818 10.1074/jbc.M008072200
37. Pitha, P. M. (2011) Innate antiviral response: role in HIV-1 infection Viruses 3 (7) 1179-203 10.3390/v3071179
38. Stroud, J. C., Oltman, A., Han, A., Bates, D. L., and Chen, L. (2009) Structural Basis of HIV-1 Activation by NF-ΰBâ€"A Higher-Order Complex of p50: RelA Bound to the HIV-1 LTR J. Mol. Biol. 393 (1) 98-112 10.1016/j.jmb.2009.08.023
39. Feng, Y. and Cohen, S. N. (2013) Upregulation of the host SLC11A1 gene by Clostridium difficile toxin B facilitates glucosylation of Rho GTPases and enhances toxin lethality Infect. Immun. 81 (8) 2724-32 10.1128/IAI.01177-12
40. Awomoyi, A. A. (2007) The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer? FEMS Immunol. Med. Microbiol. 49 (3) 324-9 10.1111/j.1574-695X.2007.00231.x
41. Agudelo, M., Gandhi, N., Saiyed, Z., Pichili, V., Thangavel, S., Khatavkar, P., Yndart-Arias, A., and Nair, M. (2011) Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA) Alcohol.: Clin. Exp. Res. 35 (8) 1550-1556 10.1111/j.1530-0277.2011.01492.x